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Molecules
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Extraction and Application of Nutrients from Food
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Extraction and Application of Nutrients from Food

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5836

Special Issue Editors

Dr. Noman Walayat

E-Mail Website
Guest Editor
Centro Tecnológico de la Carne de Galicia, Parque Tecnológico de Galicia, San Cibrán das Viñas, Rúa Galicia N 4, 32900 Ourense, Spain
Interests: oligosaccharides; antioxidants; nutrients; gelation; rheology; functional properties; proteomics
Special Issues, Collections and Topics in MDPI journals
Dr. Asad Nawaz

E-Mail Website
Guest Editor
1. Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China
2. Institute for Innovative Development of Food Industry, Shenzhen University, Shenzhen 518060, China
Interests: snacks; oxidation; in vitro/ in vivo of nutrients
Prof. Dr. Jianhua Liu

E-Mail Website
Guest Editor
College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China
Interests: proteins; cryoprotectants; antioxidants

Special Issue Information

Dear Colleagues,

Nutrients are substances found in food which drive biological activity and are essential for the human body. They are categorized as proteins, fats, carbohydrates (sugars, dietary fiber), vitamins, and minerals and perform vital functions. Further, nutrients supply the raw materials that drive multiple metabolic processes in every cell of the body. These components and their metabolites can also regulate gene expression and cellular function via a variety of mechanisms. Extraction of these nutrients is important, but the conventional extraction of nutrients frequently has negative thermal influences on extraction yield and quality. Hence, it is preferable to obtain extracts through sustainable extractions, such as microwave-assisted extraction, ultrasound-assisted extraction, high-pressure assisted extraction, high-voltage electric-discharge-assisted extraction, pulsed-electric-field-assisted extraction, and supercritical fluid extraction.

This Special Issue aims to gather the latest advances in the extraction, optimization, and characterization of nutrients from food, and applications at the industrial level, such as nutraceuticals and fortification. All these aspects will be considered in this Special Issue.

Dr. Noman Walayat
Dr. Asad Nawaz
Prof. Dr. Jianhua Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Advanced methods of nutrient extraction
  • Optimization and characterization of nutrients
  • Nutraceuticals
  • Fortification
  • Biologically active compounds
  • Sustainable management

Published Papers (3 papers)

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Research

17 pages, 4635 KiB  
Article
Assessing the Protective Role of Epigallocatechin Gallate (EGCG) against Water-Pipe Smoke-Induced Toxicity: A Comparative Study on Gene Expression and Histopathology
by Wajdy Al-Awaida, Khang Wen Goh, Hamzeh J. Al-Ameer, Yulia Sh. Gushchina, Vladimir I. Torshin, Alexandr E. Severin, Omar Al Bawareed, Besan Srour, Jude Al Farraj and Islam Hamad
Molecules 2023, 28(22), 7502; https://doi.org/10.3390/molecules28227502 - 09 Nov 2023
Viewed by 1176
Abstract
Exposure to water-pipe smoking, whether flavored or unflavored, has been shown to instigate inflammation and oxidative stress in BALB/c mice. This consequently results in alterations in the expression of inflammatory markers and antioxidant genes. This study aimed to scrutinize the impact of Epigallocatechin [...] Read more.
Exposure to water-pipe smoking, whether flavored or unflavored, has been shown to instigate inflammation and oxidative stress in BALB/c mice. This consequently results in alterations in the expression of inflammatory markers and antioxidant genes. This study aimed to scrutinize the impact of Epigallocatechin gallate (EGCG)—a key active component of green tea—on inflammation and oxidative stress in BALB/c mice exposed to water-pipe smoke. The experimental setup included a control group, a flavored water-pipe smoke (FWP) group, an unflavored water-pipe smoke (UFWP) group, and EGCG-treated flavored and unflavored groups (FWP + EGCG and UFWP + EGCG). Expression levels of IL-6, IL1B, TNF-α, CAT, GPXI, MT−I, MT−II, SOD−I, SOD−II, and SOD-III were evaluated in lung, liver, and kidney tissues. Histopathological changes were also assessed. The findings revealed that the EGCG-treated groups manifested a significant decline in the expression of inflammatory markers and antioxidant genes compared to the FWP and UFWP groups. This insinuates that EGCG holds the capacity to alleviate the damaging effects of water-pipe smoke-induced inflammation and oxidative stress. Moreover, enhancements in histopathological features were observed in the EGCG-treated groups, signifying a protective effect against tissue damage induced by water-pipe smoking. These results underscore the potential of EGCG as a protective agent against the adverse effects of water-pipe smoking. By curbing inflammation and oxidative stress, EGCG may aid in the prevention or mitigation of smoking-associated diseases. Full article
(This article belongs to the Special Issue Extraction and Application of Nutrients from Food)
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23 pages, 5331 KiB  
Article
Antispasmodic Effect of Alstonia boonei De Wild. and Its Constituents: Ex Vivo and In Silico Approaches
by Opeyemi Josephine Akinmurele, Mubo Adeola Sonibare, Anthony A. Elujoba, Akingbolabo Daniel Ogunlakin, Oloruntoba Emmanuel Yeye, Gideon Ampoma Gyebi, Oluwafemi Adeleke Ojo and Abdullah R. Alanzi
Molecules 2023, 28(20), 7069; https://doi.org/10.3390/molecules28207069 - 13 Oct 2023
Viewed by 1217
Abstract
Background: Alstonia boonei, belonging to the family Apocynaceae, is one of the best-known medicinal plants in Africa and Asia. Stem back preparations are traditionally used as muscle relaxants. This study investigated the antispasmodic properties of Alstonia boonei Stem back and its constituents. [...] Read more.
Background: Alstonia boonei, belonging to the family Apocynaceae, is one of the best-known medicinal plants in Africa and Asia. Stem back preparations are traditionally used as muscle relaxants. This study investigated the antispasmodic properties of Alstonia boonei Stem back and its constituents. Method: The freeze-dried aqueous Stem back extract of A. boonei, as well as dichloromethane (DCM), ethyl acetate, and aqueous fractions, were evaluated for their antispasmodic effect via the ex vivo method. Two compounds were isolated from the DCM fraction using chromatographic techniques, and their antispasmodic activity was evaluated. An in silico study was conducted by evaluating the interaction of isolated compounds with human PPARgamma-LBD and human carbonic anhydrase isozyme. Results: The Stem back crude extract, DCM, ethyl acetate, and aqueous fractions showed antispasmodic activity on high-potassium-induced (K+ 80 mM) contractions on isolated rat ileum with IC50 values of 0.03 ± 0.20, 0.02 ± 0.05, 0.03 ± 0.14, and 0.90 ± 0.06 mg/mL, respectively. The isolated compounds from the DCM fraction were β-amyrin and boonein, with only boonein exhibiting antispasmodic activity on both high-potassium-induced (IC50 = 0.09 ± 0.01 µg/mL) and spontaneous (0.29 ± 0.05 µg/mL) contractions. However, β-amyrin had a stronger interaction with the two proteins during the simulation. Conclusion: The isolated compounds boonein and β-amyrin could serve as starting materials for the development of antispasmodic drugs. Full article
(This article belongs to the Special Issue Extraction and Application of Nutrients from Food)
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17 pages, 3327 KiB  
Article
The Extraction and High Antiproliferative Effect of Anthocyanin from Gardenblue Blueberry
by Fengyi Zhao, Jialuan Wang, Weifan Wang, Lianfei Lyu, Wenlong Wu and Weilin Li
Molecules 2023, 28(6), 2850; https://doi.org/10.3390/molecules28062850 - 22 Mar 2023
Cited by 6 | Viewed by 2704
Abstract
Blueberries are rich in flavonoids, anthocyanins, phenolic acids, and other bioactive substances. Anthocyanins are important functional components in blueberries. We collected 65 varieties of blueberries to investigate their nutritional and functional values. Among them, Gardenblue had the highest anthocyanin content, with 2.59 mg/g [...] Read more.
Blueberries are rich in flavonoids, anthocyanins, phenolic acids, and other bioactive substances. Anthocyanins are important functional components in blueberries. We collected 65 varieties of blueberries to investigate their nutritional and functional values. Among them, Gardenblue had the highest anthocyanin content, with 2.59 mg/g in fresh fruit. After ultrasound-assisted solvent extraction and macroporous resin absorption, the content was increased to 459.81 mg/g in the dried powder. Biological experiments showed that Gardenblue anthocyanins (L1) had antiproliferative effect on cervical cancer cells (Hela, 51.98 μg/mL), liver cancer cells (HepG2, 23.57 μg/mL), breast cancer cells (MCF-7, 113.39 μg/mL), and lung cancer cells (A549, 76.10 μg/mL), and no apparent toxic effects were indicated by methyl thiazolyl tetrazolium (MTT) assay, especially against HepG2 cells both in vitro and in vivo. After combining it with DDP (cisplatin) and DOX (doxorubicin), the antiproliferative effects were enhanced, especially when combined with DOX against HepG2 cells; the IC50 value was 0.02 μg/mL. This was further evidence that L1 could inhibit cell proliferation by inducing apoptosis. The detailed mechanism might be L1 interacting with DNA in an intercalation mode that changes or destroys DNA, causing apoptosis and inhibiting cell proliferation. The findings of this study suggest that L1 extract can be used as a functional agent against hepatoma carcinoma cells. Full article
(This article belongs to the Special Issue Extraction and Application of Nutrients from Food)
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