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Special Issue "Natural Products from Plant-Associated Microorganisms"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3306

Special Issue Editor

Center for Mass Spectrometry (CMS), Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 6, 44221 Dortmund, Germany
Interests: metabolomics; imaging mass spectrometry; natural product chemistry; microbial drug discovery; antimicrobials; plant–microbe interactions; chemical ecology; molecular ecology; endophytes; phytopathogens; biocontrol organisms; biologics
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Special Issue Information

Dear Colleagues,

It is now evident from a plethora of studies that the production of secondary metabolites by plants and associated microorganisms, ranging from antimicrobial chemical defense compounds to communication molecules, is the direct or indirect result of complex and dynamic ecological interactions in nature. Any plant ecosystem would be rendered virtually non-functional without the ecologically meaningful metabolites of plant-associated micro- and macrobiota. This Special Issue invites full research papers, reviews, and short communications dealing with natural products isolated from plant-associated microorganisms, such as endophytic microorganisms, having ecological, biological, physiological, or pharmaceutical implications. Studies dealing with the role of natural products in interspecies and multispecies crosstalk of plant-associated microorganisms and how these interactions correlate with natural products' biosynthesis and plant fitness costs/benefits are also invited. Studies on natural product isolation and characterization from plant-associated microorganisms reporting the use of state-of-the-art chemical, biological, genomic, computational, and interdisciplinary omics-approaches are particularly welcome.

Priv.-Doz. Dr. Souvik Kusari
Guest Editor

Manuscript Submission Information

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  • Natural product chemistry
  • Structural elucidation
  • Structure–activity relationships
  • Biosynthesis of secondary metabolites
  • Bioactive and physiologically active natural products (e.g., allelochemicals, semiochemicals)
  • Endophytes, phytopathogens, bacteria, fungi, viruses, etc.
  • Fermentation, bioprocess design, upscaling

Published Papers (1 paper)

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19 pages, 3884 KiB  
Production of Siderophores by an Apple Root-Associated Streptomyces ciscaucasicus Strain GS2 Using Chemical and Biological OSMAC Approaches
Molecules 2021, 26(12), 3517; - 09 Jun 2021
Cited by 8 | Viewed by 2759
Apple Replant Disease (ARD) is a significant problem in apple orchards that causes root tissue damage, stunted plant growth, and decline in fruit quality, size, and overall yield. Dysbiosis of apple root-associated microbiome and selective richness of Streptomyces species in the rhizosphere typically [...] Read more.
Apple Replant Disease (ARD) is a significant problem in apple orchards that causes root tissue damage, stunted plant growth, and decline in fruit quality, size, and overall yield. Dysbiosis of apple root-associated microbiome and selective richness of Streptomyces species in the rhizosphere typically concurs root impairment associated with ARD. However, possible roles of Streptomyces secondary metabolites within these observations remain unstudied. Therefore, we employed the One Strain Many Compounds (OSMAC) approach coupled to high-performance liquid chromatography-high-resolution tandem mass spectrometry (HPLC-HRMSn) to evaluate the chemical ecology of an apple root-associated Streptomycesciscaucasicus strain GS2, temporally over 14 days. The chemical OSMAC approach comprised cultivation media alterations using six different media compositions, which led to the biosynthesis of the iron-chelated siderophores, ferrioxamines. The biological OSMAC approach was concomitantly applied by dual-culture cultivation for microorganismal interactions with an endophytic Streptomyces pulveraceus strain ES16 and the pathogen Cylindrocarpon olidum. This led to the modulation of ferrioxamines produced and further triggered biosynthesis of the unchelated siderophores, desferrioxamines. The structures of the compounds were elucidated using HRMSn and by comparison with the literature. We evaluated the dynamics of siderophore production under the combined influence of chemical and biological OSMAC triggers, temporally over 3, 7, and 14 days, to discern the strain’s siderophore-mediated chemical ecology. We discuss our results based on the plausible chemical implications of S. ciscaucasicus strain GS2 in the rhizosphere. Full article
(This article belongs to the Special Issue Natural Products from Plant-Associated Microorganisms)
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