Special Issue "Bioactive Lipids in Inflammatory Diseases"
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 7706
2. European Center for Brain Research, Santa Lucia Foundation IRCCS, Rome, Italy
Interests: arachidonate cascade; bioactive lipids; biomarkers; cell membranes; endocannabinoids; resolvins; signal transduction
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Interests: resolution biology; lipid mediators; inflammation; identification of functional biomarkers; leukocyte biology
Lipids play a diverse function in biology ranging from structural roles to energy depots and signalling molecules. Recent years have seen an increased understanding of the role that these molecules play in a range of inflammatory conditions. Of particular interest in this context are lipid molecules that carry signalling functions. It is now increasingly appreciated that these compounds act as early signals to propagate inflammation, and as modulators of the acute inflammatory response to limit its propagation and facilitate its termination and the restitution of tissue and organ function. A key aspect in the biology of such signalling molecules is stereochemistry, which confers their bioactive properties. This is because in modulating the inflammatory response these molecules activate or modulate the activity of cognate receptors in target cells, thereby activating intracellular transduction pathways. Via these processes, bioactive lipids have been implicated in the regulation of cytokine production and cellular metabolism. In turn, these molecules and processes are also known to impinge on the production of bioactive lipids, providing tightly controlled signalling pathways. Mounting evidence suggests that highly coordinated processes become dysregulated in disease, contributing to both the onset and perpetuation of inflammation, as well as disease chronicity. Of note, lipids play many physiological functions within the brain, where they impact on structural integrity, impulse conduction, myelin sheath formation, fuel source, and signal transduction. Lipid metabolism is also important for the proper function and development of the brain, where the highest concentration of lipids in the body occurs, after adipose tissue; thus, dysregulation of lipid signalling may be of relevance for brain disorders or injuries, as well as for neurodegenerative/neuroinflammatory conditions such as Huntington´s chorea, Parkinson´s diseases, multiple sclerosis, or amyotrophic lateral sclerosis. The scope of the present Special Issue is to bring together the wealth of knowledge related to the role of bioactive lipids in the maintenance of health, both within the central nervous system and at the periphery, and how disruptions in the production and activity of these molecules may be linked with diseases characterized by uncontrolled inflammation.
Prof. Dr. Mauro Maccarrone
Prof. Dr. Eva de Lago Femia
Prof. Dr. Jesmond Dalli
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- specialized pro-resolving mediators