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Antioxidants in Herbal Medicine and Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2291

Special Issue Editor

School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
Interests: antioxidant chemistry of Chinese herbal medicines; antioxidant methodology; antioxidant mechanisms; Buddhist history in China

Special Issue Information

Dear Colleagues,

Natural antioxidants play a central role in various academic fields, especially food, natural medicine, botany, and cellular metabolism. Until now, a large number of natural antioxidants have been discovered; of these, substantial amounts of natural antioxidants have been deeply investigated for their chemical or biological mechanisms. Some natural antioxidants, however, have been found to regulate biological events (e.g., cellular ferroptosis). Undoubtedly, further investigation regarding natural antioxidants will benefit the above academic fields. For this purpose, we launch this Special Issue.

Through this Special Issue, we sincerely invite our academic colleagues to provide novel findings regarding natural antioxidants from herbal medicine, plant, microorganism, or marine organism. Herein the so-called natural antioxidants refer to a new compound, known compound, and extract. For new compounds, the study should comprise a set of phytochemical work and 1-2 antioxidant bioassays. For known compounds, the study can combine its antioxidant evaluation with antioxidant mechanism (alternatively, combine chemical antioxidant evaluation with biological antioxidant evaluation). For extract or enzymatic hydrolysate, the study should include an antioxidant section and chromatograph characterization section; the antioxidant study however is advised to explore beneficial effects using both the chemical antioxidant method and biological antioxidant method. In addition, reviews concerning antioxidants in herbal medicine or natural products are also welcome; however, they should be comprehensive and offer an in-depth viewpoint.

Prof. Dr. Xican Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant evaluation
  • antioxidant mechanism
  • antioxidant peptide
  • anti-ferroptosis
  • natural products
  • herbal medicines
  • plant
  • microorganism
  • marine organism

Published Papers (2 papers)

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Research

16 pages, 4476 KiB  
Article
Structural Analysis and Antioxidant and Immunoregulatory Activities of an Exopolysaccharide Isolated from Bifidobacterium longum subsp. longum XZ01
by Xingyuan Zhang, Jing Gong, Wenyi Huang, Wen Liu, Chong Ma, Rongyao Liang, Ye Chen, Zhiyong Xie, Pei Li and Qiongfeng Liao
Molecules 2023, 28(21), 7448; https://doi.org/10.3390/molecules28217448 - 06 Nov 2023
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Abstract
Bifidobacterium longum subsp. longum XZ01 (BLSL1) is a new strain (isolated from the intestines of healthy people and deposited with the preservation number GDMCC 61618). An exopolysaccharide, S-EPS-1, was successfully isolated from the strain and then systematically investigated for the first time. Some [...] Read more.
Bifidobacterium longum subsp. longum XZ01 (BLSL1) is a new strain (isolated from the intestines of healthy people and deposited with the preservation number GDMCC 61618). An exopolysaccharide, S-EPS-1, was successfully isolated from the strain and then systematically investigated for the first time. Some structural features of S-EPS-1 were analyzed by chemical component, HPLC, ultraviolet, infrared, and nuclear magnetic resonance spectrum analyses. These analyses revealed that S-EPS-1 is a neutral heteropolysaccharide with an α-configuration. It contains mainly mannose and glucose, as well as small amounts of rhamnose and galactose. The molecular weight of S-EPS-1 was calculated to be 638 kDa. Several immunoregulatory activity assays indicated that S-EPS-1 could increase proliferation, phagocytosis, and NO production in vitro. In addition, S-EPS-1 could upregulate the expression of cytokines at the mRNA level through TLR4-mediated activation of the NF-κB signaling pathway in RAW 264.7 cells. Finally, S-EPS-1 was demonstrated to exhibit antioxidant activity by ABTS+• scavenging, DPPH scavenging, and ferric-ion reducing power assays. Furthermore, S-EPS-1 can protect cells from oxidative stress and shows no cytotoxicity. These beneficial effects can be partly attributed to its antioxidant ability. Thus, the antioxidant S-EPS-1 may be applied as a functional food in the future. Full article
(This article belongs to the Special Issue Antioxidants in Herbal Medicine and Natural Products)
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14 pages, 2676 KiB  
Article
Target-Guided Isolation and Purification of Antioxidants from Urtica laetevirens Maxim. by HSCCC Combined with Online DPPH-HPLC Analysis
by Aijing Li, Mencuo La, Huichun Wang, Jianzhong Zhao, Yao Wang, Ruisha Mian, Fangfang He, Yuhan Wang, Tingqin Yang and Denglang Zou
Molecules 2023, 28(21), 7332; https://doi.org/10.3390/molecules28217332 - 29 Oct 2023
Viewed by 928
Abstract
Urtica laetevirens Maxim. is used extensively in traditional Chinese medicine (TCM) for its potent antioxidative properties. In this study, three antioxidants were purified from U. laetevirens. using HSCCC guided by online DPPH-HPLC analysis. Firstly, the online DPPH-HPLC analysis was performed to profile out [...] Read more.
Urtica laetevirens Maxim. is used extensively in traditional Chinese medicine (TCM) for its potent antioxidative properties. In this study, three antioxidants were purified from U. laetevirens. using HSCCC guided by online DPPH-HPLC analysis. Firstly, the online DPPH-HPLC analysis was performed to profile out the antioxidant active molecules in U. laetevirens. The ultrasonic-assisted extraction conditions were optimized by response surface methodology and the results showed the targeted antioxidant active molecules could be well enriched under the optimized extraction conditions. Then, the antioxidant active molecules were separated by high-speed countercurrent chromatography ethyl acetate/n-butanol/water (2:3:5, v/v/v) as the solvent system. Finally, the three targets including 16.8 mg of Isovitexin, 9.8 mg of Isoorientin, and 26.7 mg of Apigenin-6,8-di-C-β-d-glucopyranoside were obtained from 100 mg of sample. Their structures were identified by 1H NMR spectroscopy. Full article
(This article belongs to the Special Issue Antioxidants in Herbal Medicine and Natural Products)
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