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Medicinal Plants Effects on Inflammation and Wound Healing

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2477

Special Issue Editor


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Guest Editor
King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
Interests: natural products; cancer; antimicrobial agents and resistance; ulcer; wound healing; diabetes; viruses

Special Issue Information

Dear Colleagues,

There is an urgent need for research on acute and chronic wound healing, considered by the World Health Organization a worldwide problem. Various therapeutic methods are available to help in tissue repair and the overall healing process. The specific aim of this Special Issue is to attract research showcasing novel and innovative methods using modern techniques to improve the process of wound healing and better outcomes of tissue regeneration of the skin. Such methods include nanoformulations of natural products extracted from medicinal plants and their effects on inflammation and wound healing. We aim to publish a variety of papers that will be
of interest to scholars in the field.

We invite the submission of papers ranging from those dealing with classical tissue engineering, regeneration, and repair to in vitro studies, preclinical and clinical trials of modern soft tissue replacement, and skin interaction with groundbreaking material and their associated risks. However, other ailments related to skin abrasion will also be considered. Studies related to the use of nanomaterials including the use of micro/nanomaterial-based scaffolding for the finetuning of the wound repair will be given high priority.

The ultimate goal of the announced Special Issue titled “Medicinal Plants Effects on Inflammation and Wound Healing” is to provide scientists with new and novel methods that have impacted wound-healing repair strategies, leading to improved quality of life and better economic outcomes. 

Prof. Dr. Steve Harakeh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal plants
  • wound healing (acute and chronic)
  • nanoformulations
  • skin damage and ulcerations repair
  • scaffolds and tissue regeneration
  • hydrogel-derived from biomaterials
  • in vitro, preclinical
  • clinical evaluation

Published Papers (1 paper)

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Research

14 pages, 7837 KiB  
Article
Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model
by Steve Harakeh, Mohammed S. Almuhayawi, Isaac O. Akefe, Saber H. Saber, Soad K. Al Jaouni, Torki Alzughaibi, Yousef Almehmadi, Soad Shaker Ali, Dhruba J. Bharali and Shaker Mousa
Molecules 2022, 27(5), 1605; https://doi.org/10.3390/molecules27051605 - 28 Feb 2022
Cited by 4 | Viewed by 2050
Abstract
Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against [...] Read more.
Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1β, and TNF-α. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity. Full article
(This article belongs to the Special Issue Medicinal Plants Effects on Inflammation and Wound Healing)
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