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Microneedle-Mediated Diagnosis and Therapeutics of Diseases

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1963

Special Issue Editors

College of Pharmacy, Jinan University, Guangzhou, China
Interests: microneedles; microparticles; nanoparticles
Special Issues, Collections and Topics in MDPI journals
College of Pharmacy, Jinan University, Guangzhou, China
Interests: membrane-active peptides/peptidomimetics; smarted drug delivery system; microneedles; hydrogel; nanosheets; bioinspired materials; biomaterials
Special Issues, Collections and Topics in MDPI journals
College of Pharmacy, Jinan University, Guangzhou 510006, China
Interests: dissolving microneedles for transdermal drug delivery; porous carriers for drug delivery; immunotherapy; phototherapy; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, microneedles (MNs) with micron-sized needles ranging from 100 to 1000 µm have been well-developed to pierce multiple biological barriers in a minimally invasive manner, achieving controlled-release drug delivery for therapy or extraction of tissue interstitial fluid for diagnosis. MNs could be used to deliver various agents, including small molecules, macromolecules, or a wide range of nanomedicines (e.g., polymeric nanoparticles, inorganic nanoparticles, and two-dimensional nanosheets), for the treatment of various diseases. By tailoring the drug release behavior and distribution, MNs could serve as a promising platform for the theragnostics of topical (e.g., skin diseases, oral diseases, cardiovascular diseases, and brain diseases) or systemic diseases (e.g., diabetes, contraception, and neurological disorders). In addition, the rational and personalized design of MNs provides improved pharmacokinetics, pharmacodynamics, and safety profiles to deliver fluorescent probes and/or therapeutics, making it an attractive alternative for future chemotherapy, phototherapy, immunotherapy, chemodynamic therapy, and combinatory therapies.

This Special Issue aims to highlight the recent advances in the development of smart microneedles for disease diagnosis and therapy. Original research papers, reviews, and mini-review papers are all welcome.

Dr. Tingting Peng
Dr. Chao Lu
Dr. Guilan Quan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microneedle
  • drug delivery
  • diagnosis
  • therapy
  • diseases

Published Papers (1 paper)

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Research

15 pages, 1706 KiB  
Article
An Aluminum-Based Microfluidic Chip for Polymerase Chain Reaction Diagnosis
by Siyu Yang, Ziyi Zhang, Qingyue Xian, Qi Song, Yiteng Liu, Yibo Gao and Weijia Wen
Molecules 2023, 28(3), 1085; https://doi.org/10.3390/molecules28031085 - 21 Jan 2023
Cited by 1 | Viewed by 1545
Abstract
Real-time polymerase chain reaction (real-time PCR) tests were successfully conducted in an aluminum-based microfluidic chip developed in this work. The reaction chamber was coated with silicone-modified epoxy resin to isolate the reaction system from metal surfaces, preventing the metal ions from interfering with [...] Read more.
Real-time polymerase chain reaction (real-time PCR) tests were successfully conducted in an aluminum-based microfluidic chip developed in this work. The reaction chamber was coated with silicone-modified epoxy resin to isolate the reaction system from metal surfaces, preventing the metal ions from interfering with the reaction process. The patterned aluminum substrate was bonded with a hydroxylated glass mask using silicone sealant at room temperature. The effect of thermal expansion was counteracted by the elasticity of cured silicone. With the heating process closely monitored, real-time PCR testing in reaction chambers proceeded smoothly, and the results show similar quantification cycle values to those of traditional test sets. Scanning electron microscope (SEM) and atomic force microscopy (AFM) images showed that the surface of the reaction chamber was smoothly coated, illustrating the promising coating and isolating properties. Energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma-optical emission spectrometer (ICP-OES) showed that no metal ions escaped from the metal to the chip surface. Fourier-transform infrared spectroscopy (FTIR) was used to check the surface chemical state before and after tests, and the unchanged infrared absorption peaks indicated the unreacted, antifouling surface. The limit of detection (LOD) of at least two copies can be obtained in this chip. Full article
(This article belongs to the Special Issue Microneedle-Mediated Diagnosis and Therapeutics of Diseases)
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