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Molecules
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Structural Analysis and Biological Activity of Compounds from Natural Products
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Structural Analysis and Biological Activity of Compounds from Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5344

Special Issue Editors

Dr. Haoming Luo

E-Mail Website
Guest Editor
School of Pharmacy, Changchun University of Chinese Medicine, Changchun, China
Interests: natural products; structural analysis; biological activity; extracellular vesicle; pharmacological activity
Prof. Dr. Changwu Zheng

E-Mail Website
Guest Editor
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Interests: studies on synthesis and structure optimization of bioactive compounds of medicinal plants; quality control of traditional Chinese medicine
Prof. Dr. Jincai Lu

E-Mail Website
Guest Editor
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
Interests: studies on resources, quality evaluation and development of natural plants; identification of bioactive compounds and DNA molecules

Special Issue Information

Dear Colleagues,

Natural products have been designed by nature for her own purpose. As a result of their unique ability to interact with specific biological systems, they have always served as a source of inspiration for the development of medicinally relevant scaffolds. Natural product research continues to stimulate the development of structure elucidation strategies, synthetic methodologies, and biological investigations. Therefore, the structural diversity and variety of biological properties of natural products still attract the attention of chemists, medicinal chemists, biochemists, etc.

This Special Issue on the structural analysis and biological activity of compounds will aim at merging original research and review articles to provide readers with the very last advances in this field. It will cover the development of separation techniques, spectroscopic approaches, and synthetic methodologies in structure elucidation, and the investigation of the biological actions and medicinal properties of natural products. We also wish to include synthesis-based applied research, as well as studies dealing with the biological and medicinal development of naturally derived compounds. Areas covered in this Special Issue include, but are not limited to, the following:

1) Isolation, structural elucidation, and configuration revision of bioactive natural products;

2) Synthetic studies dealing with the medicinal development of naturally derived compounds;

3) Design, modification, and structure–activity relationship studies on natural products and derivatives;

4) Mechanisms of action of natural products and derivatives.

Dr. Haoming Luo
Prof. Dr. Changwu Zheng
Prof. Dr. Jincai Lu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • structural elucidation
  • bioactive
  • derived compounds
  • structure–activity relationship

Published Papers (3 papers)

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Research

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12 pages, 1812 KiB  
Article
Oleanolic Acid Glycosides from Scabiosa caucasica and Scabiosa ochroleuca: Structural Analysis and Cytotoxicity
by Samvel Nazaryan, Antoine Bruguière, Nelli Hovhannisyan, Tomofumi Miyamoto, Alexandre M. M. Dias, Pierre-Simon Bellaye, Bertrand Collin, Loïc Briand and Anne-Claire Mitaine-Offer
Molecules 2023, 28(11), 4329; https://doi.org/10.3390/molecules28114329 - 25 May 2023
Viewed by 1231
Abstract
In the field of research on medicinal plants from the Armenian flora, the phytochemical study of two Scabiosa L. species, S. caucasica M. Bieb. and S. ochroleuca L. (Caprifoliaceae), has led to the isolation of five previously undescribed oleanolic acid glycosides from an [...] Read more.
In the field of research on medicinal plants from the Armenian flora, the phytochemical study of two Scabiosa L. species, S. caucasica M. Bieb. and S. ochroleuca L. (Caprifoliaceae), has led to the isolation of five previously undescribed oleanolic acid glycosides from an aqueous-ethanolic extract of the roots: 3-O-α-L-rhamnopyranosyl-(1→3)-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3-O-β-D-xylopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3-O-β-D-xylopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid, 3-O-β-D-xylopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester. Their full structural elucidation required extensive 1D and 2D NMR experiments, as well as mass spectrometry analysis. For the biological activity of the bidesmosidic saponins and the monodesmosidic saponin, their cytotoxicity on a mouse colon cancer cell line (MC-38) was evaluated. Full article
(This article belongs to the Special Issue Structural Analysis and Biological Activity of Compounds from Natural Products)
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14 pages, 2272 KiB  
Article
Studies on Chemical Composition of Pueraria lobata and Its Anti-Tumor Mechanism
by Xiaoxue Fang, Yegang Zhang, Yiming Cao, Mengyao Shan, Dimeng Song, Chao Ye and Difu Zhu
Molecules 2022, 27(21), 7253; https://doi.org/10.3390/molecules27217253 - 26 Oct 2022
Cited by 3 | Viewed by 1800
Abstract
Fourteen compounds were isolated from Pueraria lobata (Willd.) Ohwi by column chromatography and preparative thin-layer chromatography; the structures were identified by spectroscopic analysis and compared with data reported in the literature. Seven compounds were isolated and identified from Pueraria lobata for the first [...] Read more.
Fourteen compounds were isolated from Pueraria lobata (Willd.) Ohwi by column chromatography and preparative thin-layer chromatography; the structures were identified by spectroscopic analysis and compared with data reported in the literature. Seven compounds were isolated and identified from Pueraria lobata for the first time: Linoleic acid, Sandwicensin, Isovanillin, Ethyl ferulate, Haginin A, Isopterofuran, 3′.7-Dihydroxyisoflavan. The other 10 compounds were structurally identified as follows: Lupenone, Lupeol, β-sitosterol, Genistein, Medicarpin, Coniferyl Aldehyde, Syringaldehyde. All compounds were evaluated for their ability to inhibit SW480 and SW620 cells using the CCK-8 method; compound 5 (Sandwicensin) had the best activity, and compounds 6, 9, 11 and 12 exhibited moderate inhibitory activity. In addition, the targets and signaling pathways of Sandwicensin treatment for CRC were mined using network pharmacology, and MAPK3, MTOR, CCND1 and CDK4 were found to be closely associated with Sandwicensin treatment for CRC; the GO and KEGG analysis showed that Sandwicensin may directly regulate the cycle, proliferation and apoptosis of CRC cells through cancer-related pathways. Full article
(This article belongs to the Special Issue Structural Analysis and Biological Activity of Compounds from Natural Products)
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Review

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30 pages, 1213 KiB  
Review
American Ginseng for the Treatment of Alzheimer’s Disease: A Review
by Mengyao Shan, Yunfan Bai, Xiaoxue Fang, Xintian Lan, Yegang Zhang, Yiming Cao, Difu Zhu and Haoming Luo
Molecules 2023, 28(15), 5716; https://doi.org/10.3390/molecules28155716 - 28 Jul 2023
Cited by 1 | Viewed by 1596
Abstract
Alzheimer’s disease (AD) is a prevalent degenerative condition that is increasingly affecting populations globally. American ginseng (AG) has anti-AD bioactivity, and ginsenosides, as the main active components of AG, have shown strong anti-AD effects in both in vitro and in vivo studies. It [...] Read more.
Alzheimer’s disease (AD) is a prevalent degenerative condition that is increasingly affecting populations globally. American ginseng (AG) has anti-AD bioactivity, and ginsenosides, as the main active components of AG, have shown strong anti-AD effects in both in vitro and in vivo studies. It has been reported that ginsenosides can inhibit amyloid β-protein (Aβ) production and deposition, tau phosphorylation, apoptosis and cytotoxicity, as well as possess anti-oxidant and anti-inflammatory properties, thus suppressing the progression of AD. In this review, we aim to provide a comprehensive overview of the pathogenesis of AD, the potential anti-AD effects of ginsenosides found in AG, and the underlying molecular mechanisms associated with these effects. Additionally, we will discuss the potential use of AG in the treatment of AD, and how ginsenosides in AG may exert more potent anti-AD effects in vivo may be a direction for further research. Full article
(This article belongs to the Special Issue Structural Analysis and Biological Activity of Compounds from Natural Products)
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