Special Issue "Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope"
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 27761
2. Department of Natural products, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: natural products; cancer; inflammation; biological activities; molecular docking; ADMET
Special Issues, Collections and Topics in MDPI journals
Developed over centuries to encode biological processes, natural products represent the dawn and predecessors of medicine. Out of the desire to cure diseases, modern chemical techniques much more competent and capable in the development of new drugs were largely given precedence over conventional remedies. The designated chemotypes of natural components (β-lactam antibiotics obtained from Penicillium sp. and quinoline/iso-quinoline alkaloids obtained from tree bark are prototypical examples of therapeutically appreciated active substances) have proven their ability to act on the broad spectrum of pathogens that continue to significantly affect the health of the human population, with this representing a huge economic burden worldwide. Products of natural origin, considered to be the core of pharmaceutical armaments, are ready for access compared to synthetic products; moreover, it must be acknowledged that there is low concern regarding the maintenance of an archetype of discovery including the fermentation, isolation, structural determination, and biological testing of new pharmacologically active natural compounds. Most studies in the field have been performed to determine the pharmacokinetics and pharmacognostic potential of natural products, and fortunately, researchers have successfully isolated many new compounds. Such substances have been shown to have antibacterial, antiviral, antifungal, antimalarial, antitumor, anti-inflammatory, antioxidant, immunosuppressive, and/or cardiovascular activity, etc. Modern techniques and equipment have now made it easy to synthesize the scaffolds of natural products in the lab and save time compared to the re-isolation of natural products from their origins. However, the mode of action of many compounds, through which they interfere with human pathogenesis, has not been clarified to date, and this knowledge is essential in understanding and establishing the possibility of transforming chemical molecules into drugs.
The topic of this Special Issue is intended to cover scientific and experimental data, as well as information on drugs, in directions related to the following:
- The capacity of medicinal substances, which have been examined in vitro/ in vivo or in silico, against pathogenic microbes;
- The mode of action of these medicinal compounds and the basic mechanisms by which natural products function or act;
- Natural products derived with efficient bioactivities;
- Synthetic compounds with potential bioactivities;
- Biomolecules derived from natural products or synthesized and used in experimental or clinical studies;
- The new role of natural and synthetic products in drug targeting.
Original research articles and reviews are equally welcome.
Dr. Syed Shams ul Hassan
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- natural compounds
- synthetic compounds
- mode of action
- chronic diseases
- unconventional therapies