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Amino Acid or Peptide Based Metal Complexes

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1199

Special Issue Editors


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Guest Editor Assistant
The Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife, Nigeria
Interests: synthesis characterization and biological activities of coordination compounds; chiral coordination compounds; complexes of amino acids and derivatives; computational chemistry; porphyrazin complexes; structural elucidation

Special Issue Information

Dear Colleagues,

Amino acids and peptide ligands of metal complexes have, over the years, been established as versatile ligands with a range of various possibilities, including derivatization. These complexes provide access to compounds that display interesting stereochemistry including chirality. The synthesis and characterization of the classical natural amino acids and small peptides are well-established. However, in more recent times, focus has been more directed towards their mixed ligand complexes than on the traditional type of complexes and their various chemical and biological abilities.

The possibilities presented by peptides and amino acids metal-based complexes as pharmaceuticals are enormous. These include selectivity and affinity for the binding site, ability to fine-tune the complexes towards better reactivity and enhanced bioavailability on complexation. This gives peptide- and amino acid metal-based therapeutic agents the potential to have few side effects. Side effects and resistance have unfortunately been the bane of some drugs currently in the market. Efforts are, as a consequence, required to obtain new potent compounds as therapeutic agents with more plausible less side effects.

This Special Issue is therefore not to be deemed as viewing one complex as superior to the other, but rather as an attempt to provide information on various amino acid- and peptide-based metal complexes and their activity, thus contributing to the fast paced growing body of knowledge in this field by demonstrating their capabilities in various spheres of inorganic chemistry as well as the world of science as a whole. Both review and original research articles are welcome.

Prof. Dr. Takashiro Akitsu
Guest Editor

Dr. Temitayo O. Aiyelabola
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-based drugs
  • amino acids complexes
  • peptide/derivative metal-based complexes
  • bioinorganic chemistry
  • computational chemistry
  • metalloenzyme inhibition
  • coordination compounds

Published Papers (1 paper)

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Research

10 pages, 1947 KiB  
Article
Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution
by Marek Pająk, Elżbieta Kamysz, Karol Sikora, Jakub Fichna and Magdalena Woźniczka
Molecules 2024, 29(1), 90; https://doi.org/10.3390/molecules29010090 - 22 Dec 2023
Viewed by 736
Abstract
The present work describes the complexation of the anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature of 25.0 ± 0.1 °C, over the whole pH range. The complexing properties were characterized by potentiometric and UV-Vis [...] Read more.
The present work describes the complexation of the anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature of 25.0 ± 0.1 °C, over the whole pH range. The complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. The potentiometric method was used to calculate the logarithms of the overall stability constants (log β) and the values of the stepwise dissociation constants (pKa) of the studied complexes. The percentage of each species formed in an aqueous solution was estimated from the species distribution curve as a function of pH. The absorbance (A) and molar absorption coefficient (ε) values for the Cu(II)-sialorphin derivative system were determined with UV-Vis spectroscopy. Our studies indicate that the sialorphin derivative forms stable complexes with Cu(II) ions, which may lead to future biological and therapeutic applications. Full article
(This article belongs to the Special Issue Amino Acid or Peptide Based Metal Complexes)
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