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Advances of Polymer Nanocomposites for Antimicrobial Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5023

Special Issue Editors


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Guest Editor
International Centre for Research on Innovative Bio-based Materials, ICRI-BioM, Lodz University of Technology, Lodz, Poland
Interests: antimicrobial food packaging/biomedical devices; CO2 conversion; green H2 production; self-cleaning coatings; energy storage devices
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Guest Editor
Centre for Biomaterials, Cellular, and Molecular Theranostics (CBCMT), Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, India
Interests: 3D and 4D printing; smart biomaterials; nanobiomaterials; polymer nanocomposites; dental materials; paper-based sensors; antimicrobial materials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Polymer and Biomaterial Group (PolyBioMat), International Centre for Research on Innovative Bio-based Materials (ICRI-BioM), Lodz University of Technology, Lodz, Poland
Interests: tissue engineering; biomaterials; biotechnology; drug release; polymers; implants; hydrogels; wound dressings; antimicrobial biomaterials

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Guest Editor
Regenerative Medicine Application and Research Center, University of Health Sciences, İstanbul, Turkey
Interests: implants; antimicrobial surfaces and coatings; tissue engineering; bioceramics; ion doping; 3D printing and bioprinting; material characterization

Special Issue Information

Dear Colleagues,

Throughout the history of mankind, infectious diseases caused by bacteria, fungi, viruses, or other pathogens have resulted in the development of mild to severe health issues. These tiny pathogens are impossible to detect by the naked eye and are capable of adhering to surfaces, undergoing rapid population and forming microenvironments harmful to humans once specific conditions are met. The recent COVID-19 pandemic has clearly alerted about the necessity of highly effective antimicrobial surfaces, medical devices, and polymers to curtail the spread of infectious pathogens. Even though a myriad number of antibiotics have been developed to fight against infectious diseases during the last century, antimicrobial resistance (AMR) and newly emerging pathogens remain challenges. According to a report, more than EUR 1.5 billion has been spent annually in treating various drug-resistant infections. In this aspect, antimicrobial polymers are receiving remarkable attention in recent years regarding their potential application in destroying infectious pathogens. Polymer nanocomposites (PNs, both synthetic and natural polymer composites) including nanosheets, flakes, fibers, whiskers, stars, spheres, and a variety of other forms are preferable to modify the properties of the endproduct with respect to chemical, biological, mechanical, morphological, and antimicrobial aspects. The antimicrobial features of PNs are vital in modern medicine and surgical operations. Therefore, several investigations have been carried out in recent years on the significance of polymer nanocomposites in treating various microbial infections. The main aim of this Special Issue is to disclose the key findings of research on PNs for antimicrobial applications.

We are pleased to invite submissions in the form of original research articles, communications, prospects, and short reviews that reflect the key findings regarding the use of PNs in various applications related to their broad-spectrum antimicrobial activity, stimuli-responsive activity, antifouling–microbicidal effect, self-adaptive antimicrobial action, or multimodal sensing properties.

This Special Issue is not limited to the abovementioned topics but also welcomes manuscripts on the antimicrobial features of PNs in relation to dental infections, 2D membranes, wound dressing/healing, anticancer drugs, scaffolds, medical implants, etc.

Dr. Vignesh Kumaravel
Dr. A. Joseph Nathanael
Dr. Deniz Atila
Dr. Bengi Yilmaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial
  • antiviral
  • antifungal
  • biomaterials
  • 2D materials
  • 3D printing
  • natural polymers
  • hydrogels

Published Papers (2 papers)

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Research

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17 pages, 4614 KiB  
Article
Antimicrobial Activities of Polyethylene Terephthalate-Waste-Derived Nanofibrous Membranes Decorated with Green Synthesized Ag Nanoparticles
by Tannaz Soltanolzakerin-Sorkhabi, Mehrab Fallahi-Samberan and Vignesh Kumaravel
Molecules 2023, 28(14), 5439; https://doi.org/10.3390/molecules28145439 - 16 Jul 2023
Cited by 2 | Viewed by 1823
Abstract
Thermoplastic polymers are one of the synthetic materials produced with high tonnage in the world and are so omnipresent in industries and everyday life. One of the most important polymeric wastes is polyethylene terephthalate (PET), and the disposal of used PET bottles is [...] Read more.
Thermoplastic polymers are one of the synthetic materials produced with high tonnage in the world and are so omnipresent in industries and everyday life. One of the most important polymeric wastes is polyethylene terephthalate (PET), and the disposal of used PET bottles is an unsolved environmental problem, and many efforts have been made to find practical solutions to solve it. In this present work, nanofibrous membranes were produced from waste PET bottles using the electrospinning process. The surface of membranes was modified using NaOH and then decorated with green synthesized Ag nanoparticles (10 ± 2 nm) using an in situ chemical reduction method. The morphology, size, and diameter of the Ag nanoparticles decorating the nanofibers were characterized through transmission electron microscopy (TEM), a field emission scanning electron microscope (FESEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and UV-visible spectroscopy techniques. Finally, the antimicrobial activity of the nanofibrous membranes was tested against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus using disc diffusion and colony-forming count methods. The growth of bacteria was not affected by the pure nanofibrous membranes, while the Ag-decorated samples showed inhibition zones of 17 ± 1, 16 ± 1, and 14 ± 1 mm for Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, respectively. The planktonic culture results of Pseudomonas aeruginosa showed that the membranes had a relatively low inhibitory effect on its growth. The obtained results showed that Pseudomonas aeruginosa has a relatively low ability to form biofilms on the nanostructured membranes too. A good agreement was observed between the data of biofilm formation and the planktonic cultures of bacteria. The plastic-waste-derived PET/Ag nanocomposite membranes can be used for wound dressings, air filters, and water purification applications. Full article
(This article belongs to the Special Issue Advances of Polymer Nanocomposites for Antimicrobial Applications)
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Review

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31 pages, 3010 KiB  
Review
Chitosan-Based Scaffolds for the Treatment of Myocardial Infarction: A Systematic Review
by Bryan Beleño Acosta, Rigoberto C. Advincula and Carlos David Grande-Tovar
Molecules 2023, 28(4), 1920; https://doi.org/10.3390/molecules28041920 - 17 Feb 2023
Cited by 8 | Viewed by 2697
Abstract
Cardiovascular diseases (CVD), such as myocardial infarction (MI), constitute one of the world’s leading causes of annual deaths. This cardiomyopathy generates a tissue scar with poor anatomical properties and cell necrosis that can lead to heart failure. Necrotic tissue repair is required through [...] Read more.
Cardiovascular diseases (CVD), such as myocardial infarction (MI), constitute one of the world’s leading causes of annual deaths. This cardiomyopathy generates a tissue scar with poor anatomical properties and cell necrosis that can lead to heart failure. Necrotic tissue repair is required through pharmaceutical or surgical treatments to avoid such loss, which has associated adverse collateral effects. However, to recover the infarcted myocardial tissue, biopolymer-based scaffolds are used as safer alternative treatments with fewer side effects due to their biocompatibility, chemical adaptability and biodegradability. For this reason, a systematic review of the literature from the last five years on the production and application of chitosan scaffolds for the reconstructive engineering of myocardial tissue was carried out. Seventy-five records were included for review using the “preferred reporting items for systematic reviews and meta-analyses” data collection strategy. It was observed that the chitosan scaffolds have a remarkable capacity for restoring the essential functions of the heart through the mimicry of its physiological environment and with a controlled porosity that allows for the exchange of nutrients, the improvement of the electrical conductivity and the stimulation of cell differentiation of the stem cells. In addition, the chitosan scaffolds can significantly improve angiogenesis in the infarcted tissue by stimulating the production of the glycoprotein receptors of the vascular endothelial growth factor (VEGF) family. Therefore, the possible mechanisms of action of the chitosan scaffolds on cardiomyocytes and stem cells were analyzed. For all the advantages observed, it is considered that the treatment of MI with the chitosan scaffolds is promising, showing multiple advantages within the regenerative therapies of CVD. Full article
(This article belongs to the Special Issue Advances of Polymer Nanocomposites for Antimicrobial Applications)
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