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Molecules
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Discovery and Research of Novel Bioactive Natural Compounds
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Discovery and Research of Novel Bioactive Natural Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1248

Special Issue Editor

Prof. Dr. Guangxiong Zhou

E-Mail Website
Guest Editor
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China
Interests: marine microorganisms; natural products; traditional Chinese medicine products; anti-tumor; anti-fungal; anti-diabetic activities

Special Issue Information

Dear Colleagues,

Bioactive natural compounds are rich in beneficial resources from plants, animals, insects, marine creatures, microorganisms and metabolites from biosomes. They are known to contain various active principles of therapeutic value, healthcare value and possess biological activity against a number of diseases.

Interest in the field of bioactive natural compounds has been increasing in both developed and developing countries. The aim of this Special Issue on “Discovery and Research of Novel Bioactive Natural Compounds” is to present research and findings on naturally derived compounds. Original research articles or review articles regarding the isolation, extraction, bioactive evaluation and applications of novel natural compounds are welcome.

Prof. Dr. Guangxiong Zhou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds
  • plant extracts
  • marine natural products
  • bioactive effects
  • drug discovery
  • health benefits

Published Papers (1 paper)

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Research

12 pages, 2172 KiB  
Article
The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli
by Hanna Chen, Xianping Bai, Tao Sun, Xingyan Wang, Youming Zhang, Xiaoying Bian and Haibo Zhou
Molecules 2023, 28(19), 6937; https://doi.org/10.3390/molecules28196937 - 05 Oct 2023
Viewed by 1077
Abstract
Glutarimide-containing polyketides exhibiting potent antitumor and antimicrobial activities were encoded via conserved module blocks in various strains that favor the genomic mining of these family compounds. The bioinformatic analysis of the genome of Burkholderia gladioli ATCC 10248 showed a silent trans-AT PKS [...] Read more.
Glutarimide-containing polyketides exhibiting potent antitumor and antimicrobial activities were encoded via conserved module blocks in various strains that favor the genomic mining of these family compounds. The bioinformatic analysis of the genome of Burkholderia gladioli ATCC 10248 showed a silent trans-AT PKS biosynthetic gene cluster (BGC) on chromosome 2 (Chr2C8), which was predicted to produce new glutarimide-containing derivatives. Then, the silent polyketide synthase gene cluster was successfully activated via in situ promoter insertion and heterologous expression. As a result, seven glutarimide-containing analogs, including five new ones, gladiofungins D-H (3–7), and two known gladiofungin A/gladiostatin (1) and 2 (named gladiofungin C), were isolated from the fermentation of the activated mutant. Their structures were elucidated through the analysis of HR-ESI-MS and NMR spectroscopy. The structural diversities of gladiofungins may be due to the degradation of the butenolide group in gladiofungin A (1) during the fermentation and extraction process. Bioactivity screening showed that 2 and 4 had moderate anti-inflammatory activities. Thus, genome mining combined with promoter engineering and heterologous expression were proved to be effective strategies for the pathway-specific activation of the silent BGCs for the directional discovery of new natural products. Full article
(This article belongs to the Special Issue Discovery and Research of Novel Bioactive Natural Compounds)
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