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Preparation, Characterization, and Effect of Lipid Nanoparticles Used in Different Application Fields IV

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1665

Special Issue Editor

Special Issue Information

Dear Colleagues,

Nanotechnology profoundly impacts our lives in many ways, both positively and negatively. The recent interest in nanoscale products emerged from modern nanotechnology as a multidisciplinary area. Many studies have demonstrated that lipid-based nanoparticles (e.g., nanostructured lipid carriers, solid lipid nanoparticles, nanoemulsions, liposomes, and cubosomes) are largely used to ameliorate the solubility of active principles or to obtain a controlled or target release, creating a modifiable system able to be adapted according to the product requirements. Lipid-based nanoparticles demonstrated their ability to solubilize a number of molecules with different physicochemical properties in well-established, safe, biocompatible and biodegradable matrixes, contributing, as a natural resource, to green nanosystems. When these properties are taken together, lipid-based nanosystems are versatile systems with applications in many fields, including the environmental, veterinary, nutraceutical, cosmetic, biotechnological, biomedical, and pharmaceutical industries. The great level of interest in the various applications of lipid nanoparticles presented in the first three editions of this Special Issue motivated us to propose a fourth installment in this series in order to provide an open forum with the aim of encouraging elaboration upon the research and findings in the field of nanotechnology. Submissions may be in the form of original research or review articles and may focus on a range of issues, such as the production, characterization, structure, and innovative aspects of lipid nanoparticles, possibly presenting new preparation methods, advantages, disadvantages, lipid nanoparticle functionalization, and new applications. Studies with multidisciplinary inputs offering innovative methodologies or insights are also welcome.

Prof. Dr. Rita Cortesi
Guest Editor

Manuscript Submission Information

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Keywords

  • nanocarriers
  • nanotechnology
  • SLN
  • NLC
  • liposomes
  • drug delivery
  • nanomedicine
  • green agriculture

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Published Papers (1 paper)

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Research

20 pages, 20959 KiB  
Article
Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro
by Xiaoxue Wang, Jinli Liu, Yufei Ma, Xinyu Cui, Cong Chen, Guowei Zhu, Yue Sun and Lei Tong
Molecules 2023, 28(18), 6668; https://doi.org/10.3390/molecules28186668 - 17 Sep 2023
Cited by 1 | Viewed by 1257
Abstract
Non-small-cell lung cancer (NSCLC) is the main cause of cancer-related deaths worldwide, with a low five-year survival rate, posing a serious threat to human health. In recent years, the delivery of antitumor drugs using a nanostructured lipid carrier (NLC) has become a subject [...] Read more.
Non-small-cell lung cancer (NSCLC) is the main cause of cancer-related deaths worldwide, with a low five-year survival rate, posing a serious threat to human health. In recent years, the delivery of antitumor drugs using a nanostructured lipid carrier (NLC) has become a subject of research. This study aimed to develop an apigenin (AP)-loaded nanostructured lipid carrier (AP-NLC) by melt sonication using glyceryl monostearate (GMS), glyceryl triacetate, and poloxamer 188. The optimal prescription of AP-NLC was screened by central composite design response surface methodology (CCD-RSM) based on a single-factor experiment using encapsulation efficiency (EE%) and drug loading (DL%) as response values and then evaluated for its antitumor effects on NCI-H1299 cells. A series of characterization analyses of AP-NLC prepared according to the optimal prescription were carried out using transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). Subsequent screening of the lyophilization protectants revealed that mannitol could better maintain the lyophilization effect. The in vitro hemolysis assay of this formulation indicated that it may be safe for intravenous injection. Moreover, AP-NLC presented a greater ability to inhibit the proliferation, migration, and invasion of NCI-H1299 cells compared to AP. Our results suggest that AP-NLC is a safe and effective nano-delivery vehicle that may have beneficial potential in the treatment of NSCLC. Full article
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