New Trends in Developing Complexes as Biological Active Species II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 995
Special Issue Editor
Interests: coordination chemistry; biological active species (organic and inorganic); characterization methods (ESI-MS, NMR, IR, EPR)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The diseases evolution makes classical organic drugs ineffective in most cases. Several strategies were developed in order to find new effective species for treatment, that take into account the complexes, especially those bearing transition metal ions and multidentate ligands. Some species of this type were developed in recent years as valuable antitumor, antimicrobial, anti-inflammatory, anti-infective, or antiparasitic agents, effective both in vitro and in vivo. Important aspects that need to be clarified in the development of such compounds as drugs are the interaction with serum and cytoplasmic bio-species, as well as with the target sites, which most often are DNA and enzymes.
As a result, this Special Issue will cover complex aspects concerning the design, synthesis, characterisation and in vitro or in vivo assay of various complexes developed as potential biological active species.
Dr. Rodica Olar
Guest Editor
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Keywords
- complex
- transition metal ion
- chelate ligand
- antimicrobial
- biofilm
- antiproliferative activity
- multi-resistant strains
- biomolecule interaction
- in vitro assay
- in vivo assay
- metallo-nuclease activity
- docking simulation
