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Advances on Marine Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2287

Special Issue Editor

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Interests: marine natural product; drug leads; pharmacological mechanism; marine microorganisms; cyanobacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the investigation of novel and bioactive natural products from marine organisms. Marine organisms have proven to be a rich and powerful source of unimaginable natural products with novel chemical structures and unique pharmacological activities, which have already played a large role in drug development, and some will have good research prospects in the future. More than 70% of our planet’s surface is covered by oceans, and using technical advances in diving and remotely operated vehicles, it is becoming easier to collect samples. Marine organisms remain an excellent source of innovative compounds that have the potential for the development of new drugs.

This Special Issue will focus on advances in all aspects of marine natural lead compounds for drug discovery and development, including the following aspects:

  • Structurally new and bioactive natural products from marine macro- and microorganisms;
  • Structures and functions of marine biomacromolecules;
  • Efficacy and pharmacological mechanisms of MNPs;
  • Total synthesis, optimization or biosynthesis of bioactive or novel MNPs;
  • Marine medicinal biological resources research.

Dr. Bin Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • marine biomacromolecules
  • marine bioactive compounds
  • biosynthetic pathway
  • pharmacological mechanism
  • marine biological resources
  • biological activity
  • total synthesis
  • structure–activity relationships

Published Papers (2 papers)

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Research

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11 pages, 2022 KiB  
Article
Arthproliferins A–D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221
by Bin Yang, Cuitian Li, Ying Chen, Yanchun He, Jianglian She, Xuefeng Zhou, Huangming Tao and Bo Peng
Molecules 2023, 28(21), 7246; https://doi.org/10.3390/molecules28217246 - 24 Oct 2023
Viewed by 743
Abstract
Four new sesterterpenes, arthproliferins A–D (14), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of [...] Read more.
Four new sesterterpenes, arthproliferins A–D (14), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin (6) exhibited significant activity with an IC50 value of 20.3 μM, and compounds 2 and 5 were found to show weak inhibitory effects against U87MG-derived GSCs. Full article
(This article belongs to the Special Issue Advances on Marine Natural Products)
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Review

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22 pages, 2948 KiB  
Review
Exploring Diverse Bioactive Secondary Metabolites from Marine Microorganisms Using Co-Culture Strategy
by Xiaolin Li, Huayan Xu, Yuyue Li, Shengrong Liao and Yonghong Liu
Molecules 2023, 28(17), 6371; https://doi.org/10.3390/molecules28176371 - 31 Aug 2023
Cited by 1 | Viewed by 1267
Abstract
The isolation and identification of an increasing number of secondary metabolites featuring unique skeletons and possessing diverse bioactivities sourced from marine microorganisms have garnered the interest of numerous natural product chemists. There has been a growing emphasis on how to cultivate microorganisms to [...] Read more.
The isolation and identification of an increasing number of secondary metabolites featuring unique skeletons and possessing diverse bioactivities sourced from marine microorganisms have garnered the interest of numerous natural product chemists. There has been a growing emphasis on how to cultivate microorganisms to enhance the chemical diversity of metabolites and avoid the rediscovery of known ones. Given the significance of secondary metabolites as a means of communication among microorganisms, microbial co-culture has been introduced. By mimicking the growth patterns of microbial communities in their natural habitats, the co-culture strategy is anticipated to stimulate biosynthetic gene clusters that remain dormant under traditional laboratory culture conditions, thereby inducing the production of novel secondary metabolites. Different from previous reviews mainly focusing on fermentation conditions or metabolite diversities from marine-derived co-paired strains, this review covers the marine-derived co-culture microorganisms from 2012 to 2022, and turns to a particular discussion highlighting the selection of co-paired strains for marine-derived microorganisms, especially the fermentation methods for their co-cultural apparatus, and the screening approaches for the convenient and rapid detection of novel metabolites, as these are important in the co-culture. Finally, the structural and bioactivity diversities of molecules are also discussed. The challenges and prospects of co-culture are discussed on behave of the views of the authors. Full article
(This article belongs to the Special Issue Advances on Marine Natural Products)
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