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Curcumin: New Trends and Health Benefits

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3958

Special Issue Editor


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Guest Editor
Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska street 211A, 50-556 Wroclaw, Poland
Interests: cell death; apoptosis; oxidative stress; anti-cancer new therapy; electrochemotherapy; natural compounds; cell metabolism; drug resistance
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Special Issue Information

Dear Colleagues, 

Curcumin is a phytochemical substance that demonstrates powerful healing properties!

The properties of curcumin are antioxidant and anti-inflammatory. Therefore, curcumin is ideal for preventing and treating diseases associated with oxidative stress and inflammation. It is noteworthy that curcumin has been known for its wide range of beneficial effects over thousands of years. Still, the biological impact of this factor has only been understood in recent years.

Despite proven efficacy against numerous experimental models, poor bioavailability due to poor absorption, rapid metabolism, and rapid systemic elimination have been shown to limit the therapeutic efficacy of curcumin. Our goal is to invite relevant research teams, to provide new research on the mechanism of antioxidant and anti-inflammatory reaction in vitro and in vivo study. Also the possibility of increasing curcumin bioavailability. This Special Issue invites researchers to contribute reviews and original research reports of their recent work based on investigations of curcumin as an anti-inflammatory agent and anti-carcinogenic actions via modulating various signalling molecules, anticancer properties, and another acting.

Dr. Jolanta Saczko
Guest Editor

Manuscript Submission Information

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Keywords

  • curcumin
  • cancer
  • inflamatory
  • oxidative stress
  • apoptosis
  • biocompatibility
  • nanoparticles

Published Papers (1 paper)

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Research

15 pages, 4466 KiB  
Article
The Role of Ferroptosis and Cuproptosis in Curcumin against Hepatocellular Carcinoma
by Zhili Liu, Huihan Ma and Zelin Lai
Molecules 2023, 28(4), 1623; https://doi.org/10.3390/molecules28041623 - 08 Feb 2023
Cited by 14 | Viewed by 3650
Abstract
Background: Among cancer-related deaths, hepatocellular carcinoma (HCC) ranks fourth, and traditional Chinese medicine (TCM) treatment is an important complementary alternative therapy for HCC. Curcumin is a natural ingredient extracted from Curcuma longa with anti-HCC activity, while the therapeutic mechanisms of curcumin remain unclear, [...] Read more.
Background: Among cancer-related deaths, hepatocellular carcinoma (HCC) ranks fourth, and traditional Chinese medicine (TCM) treatment is an important complementary alternative therapy for HCC. Curcumin is a natural ingredient extracted from Curcuma longa with anti-HCC activity, while the therapeutic mechanisms of curcumin remain unclear, especially on ferroptosis and cuproptosis. Methods: Differentially expressed genes (DEGs) of curcumin treatment in PLC, KMCH, and Huh7 cells were identified, respectively. The common genes among them were then obtained to perform functional enrichment analysis and prognostic analysis. Moreover, weighted gene co-expression network analysis (WGCNA) was carried out for the construction of the co-expression network. The ferroptosis potential index (FPI) and the cuproptosis potential index (CPI) were subsequently used to quantitatively analyze the levels of ferroptosis and cuproptosis. Finally, single-cell transcriptome analysis of liver cancer was conducted. Results: We first identified 702, 515, and 721 DEGs from curcumin-treated PLC, KMCH, and Huh7 cells, respectively. Among them, HMOX1, CYP1A1, HMGCS2, LCN2, and MTTP may play an essential role in metal ion homeostasis. By WGCNA, grey60 co-expression module was associated with curcumin treatment and involved in the regulation of ion homeostasis. Furthermore, FPI and CPI assessment showed that curcumin had cell-specific effects on ferroptosis and cuproptosis in different HCC cells. In addition, there are also significant differences in ferroptosis and cuproptosis levels among 16 HCC cell subtypes according to single-cell transcriptome data analysis. Conclusions: We developed CPI and combined it with FPI to quantitatively analyze curcumin-treated HCC cells. It was found that ferroptosis and cuproptosis, two known metal ion-mediated forms of programmed cell death, may have a vital effect in treating HCC with curcumin, and there are significant differences in various liver cancer cell types and curcumin treatment which should be considered in the clinical application of curcumin. Full article
(This article belongs to the Special Issue Curcumin: New Trends and Health Benefits)
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