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Identification of Bioactive Compounds from Natural Products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2146

Special Issue Editors

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Guest Editor
Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA
Interests: food science; food chemistry; emerging technologies; bioactive compounds; bio-waste recovery; food innovation

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Guest Editor
Department of Agri-Food industry, Food and Nutrition, Universidade de Sao Paulo (USP), Sao Paulo, Brazil
Interests: natural products; phenolic compounds; antioxidant activity; bioaccessibility and bioavailability; mass spectrometry

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Guest Editor
Department of Analytical and Food Chemistry, Food Science and Technology Faculty, University of Vigo, 32004 Ourense, Spain
Interests: agro-environmental; food chemistry; sustainable primary production; food quality and safety
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Guest Editor Assistant
Faculdade de Engenharia de Alimentos (FEA), University of Campinas (UNICAMP), São Paulo, Brazil
Interests: biorefinery; bioenergy; biogas; biomethane; sustainability; waste valorization; bioeconomy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Identifying bioactive compounds from natural products is an area that has been extensively explored and still has much to be discovered. These compounds are obtained from the secondary metabolism of plants and have shown commercial value in the cosmetic, food, and pharmaceutical industries. The identification of bioactive compounds is necessary to improve biological activity such as antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial, antiobesity, and antihypertensive, as well as the use of cosmetic and food industries. Therefore, this Special Issue aims to provide an updated report on the bioactive compounds from natural products in plants and their application in different fields.  This Special Issue of Molecules will advance the knowledge of bioactive compounds from natural products, including: i) identifying the profile of bioactive compounds in natural products; ii) optimizing the extraction (classical and modern techniques) of bioactive compounds; iii) identifying bioactive compounds using modern analytical techniques; iv) isolating and purifying bioactive compounds; and v) applying bioactive compounds in the food, cosmetic, and pharmaceutical industries.

Dr. Aline Priscilla Gomes Da Silva
Prof. Dr. Severino De Alencara
Prof. Dr. Jesus Simal-Gandara
Guest Editors

William Gustavo Sganzerla
Guest Editor Assistant

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  • identification
  • phytochemicals
  • anthocyanins
  • phenolic acids
  • proanthocyanidins
  • metabolomics
  • HPLC

Published Papers (1 paper)

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25 pages, 3395 KiB  
Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan
by Hossam S. El-Beltagi, Salwa M. El-Sayed, Ahmed. N. Abdelhamid, Karim. M. Hassan, Walaa. A. Elshalakany, Mona Ibrahim Nossier, Nadiyah M. Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas and Hemmat A. Ibrahim
Molecules 2023, 28(8), 3642; - 21 Apr 2023
Cited by 5 | Viewed by 1649
Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus. ĸ-carrageenan has been proven as plant growth promoting substance [...] Read more.
Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus. ĸ-carrageenan has been proven as plant growth promoting substance for a number of medicinal and agricultural plants. Considering the importance of ĸ-carrageenan as a promoter of plant growth and phytochemical constituents, especially alkaloids production in Catharanthus roseus, an experiment was carried out to explore the effect of ĸ-carrageenan on the plant growth, phytochemicals content, pigments content, and production of antitumor alkaloids in Catharanthus roseus after planting. Foliar application of ĸ-carrageenan (at 0, 400, 600 and 800 ppm) significantly improved the performance of Catharanthus roseus. Phytochemical analysis involved determining the amount of total phenolics (TP), flavonoids (F), free amino acids (FAA), alkaloids (TAC) and pigments contents by spectrophotometer, minerals by ICP, amino acids, phenolic compounds and alkaloids (Vincamine, Catharanthine, Vincracine (Vincristine), and vinblastine) analysis uses HPLC. The results indicated that all examined ĸ-carrageenan treatments led to a significant (p ≤ 0.05) increase in growth parameters compared to the untreated plants. Phytochemical examination indicates that the spray of ĸ-carrageenan at 800 mg L−1 increased the yield of alkaloids (Vincamine, Catharanthine and Vincracine (Vincristine)) by 41.85 μg/g DW, total phenolic compounds by 3948.6 μg gallic/g FW, the content of flavonoids 951.3 μg quercetin /g FW and carotenoids content 32.97 mg/g FW as compared to the control. An amount of 400 ppm ĸ-carrageenan treatment gave the best contents of FAA, Chl a, Chl b and anthocyanin. The element content of K, Ca, Cu, Zn and Se increased by treatments. Amino acids constituents and phenolics compounds contents were altered by ĸ-carrageenan. Full article
(This article belongs to the Special Issue Identification of Bioactive Compounds from Natural Products)
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