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Phytochemical and Biological Activities of Natural Product with Application in Pharmacy and Food Technologies

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2327

Special Issue Editors

Dr. Krastena Nikolova

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Guest Editor
Medical University-Varna, Department of Physics and Biophysics, Varna, Bulgaria
Interests: optical properties of extracts; antioxidant activities; green methods for extraction; applied photonics
Dr. Irina B. Karadjova

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Guest Editor
Faculty of Chemistry and Pharmacy, University of Sofia “St. Kliment Ohridski”, 1164 Sofia, Bulgaria
Interests: antioxidant activities; green methods for extraction; element analysis; speciation analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Nadezhda Petkova

E-Mail Website
Guest Editor
Department of Organic Chemistry and Inorganic Chemistry, University of Food Technologies, 4002 Plovdiv, Bulgaria
Interests: antioxidant activities; green methods for extraction; phytochemistry
Dr. Galia Gentscheva

E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, Medical University-Pleven, 5800 Pleven, Bulgaria
Interests: analytical chemistry; atomic absorption spectroscopy; agricultural plant science; food science

Special Issue Information

Dear Colleagues,

Medicinal plants, which come in a rich variety, can be used as enhancers of human life, such as for healthy eating, disease treatment, cosmetics, etc. According to the World Health Organization (WHO), approximately 80% of the Earth's population uses herbal treatment and phytotherapy for primary medical care. From such a point of view, knowledge of the phytochemical properties, antioxidant activity and biological effects of natural products is essential. The combination of different natural products can lead to a synergistic or antagonistic effect on different processes in the body. These effects depend on the method of application on the one hand and the timing of their use on the other. Selected phototherapeutic agents are taken orally or applied externally depending on their properties and toxicity. Long-term administration or intake is critical to improve the health of the user due to these agents’ slow action in the absence of side effects.

This Special Issue aims to:

  • Summarize innovative technologies for the extraction of biologically active substances from medicinal plants, without losing effectiveness.
  • Collect data on the phytochemical properties of specific components obtained from natural products with the aim of applying them in nutritional supplements, cosmetic products, medical devices and / or functional foods.
  • Track the biological effects of developed and new preparations through various models, with the end goal of scaling up and commercializing the process.

Dr. Krastena Nikolova
Dr. Irina B. Karadjova
Dr. Nadezhda Petkova
Dr. Galia Gentscheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive molecules
  • medical plants
  • antioxidant activity
  • bioactive compounds
  • food and pharmaceuticals application

Published Papers (2 papers)

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Research

13 pages, 1325 KiB  
Article
Effects of Bacterioruberin-Rich Haloarchaeal Carotenoid Extract on the Thermal and Oxidative Stabilities of Fish Oil
by Fevziye Işıl Kesbiç, Hilal Metin, Francesco Fazio, Vincenzo Parrino and Osman Sabri Kesbiç
Molecules 2023, 28(24), 8023; https://doi.org/10.3390/molecules28248023 - 09 Dec 2023
Cited by 1 | Viewed by 773
Abstract
This study aimed to assess the efficacy of a bacterioruberin-rich carotenoid extract (HAE) derived from the halophilic archaea Halorubrum ezzemoulense DSM 19316 in protecting crude fish oil against thermal oxidation. The research used fish oil derived from anchovies, which had a peroxide value [...] Read more.
This study aimed to assess the efficacy of a bacterioruberin-rich carotenoid extract (HAE) derived from the halophilic archaea Halorubrum ezzemoulense DSM 19316 in protecting crude fish oil against thermal oxidation. The research used fish oil derived from anchovies, which had a peroxide value (PV) of 6.44 ± 0.81 meq O2 kg−1. To assess the impact of HAE on the thermal stability and post-oxidation characteristics of fish oil, several concentrations of HAE were added to the fish oil samples: 0 ppm (no additive) (HAE0), 50 ppm (HAE50), 100 ppm (HAE100), 500 ppm (HAE500), and 1000 ppm (HAE1000). Furthermore, a control group was established with the addition of 100 ppm butylated hydroxytoluene (BHT100) in order to evaluate the effectiveness of HAE with a synthetic antioxidant that is commercially available. Prior to the fast oxidation experiment, thermogravimetric analysis was conducted on samples from all experimental groups. At the conclusion of the examination, it was seen that the HAE500 and HAE1000 groups exhibited a delay in the degradation temperature. The experimental groups underwent oxidation at a temperature of 55.0 ± 0.5 °C for a duration of 96 h. The measurement of PV was conducted every 24 h during this time. PV in all experimental groups exhibited a time-dependent rise (p < 0.05). However, the HAE500 group had the lowest PV measurement at the conclusion of the 96 h period (p < 0.05). Significant disparities were detected in the fatty acid compositions of the experimental groups at the completion of the oxidation experiment. The HAE500 group exhibited the highest levels of EPA, DHA, and ΣPUFA at the end of oxidation, with statistical significance (p < 0.05). Through the examination of volatile component analysis, specifically an oxidation marker, it was shown that the HAE500 group exhibited the lowest level of volatile components (p < 0.05). Consequently, it was concluded that the addition of HAE to fish oil provided superior protection compared to BHT at an equivalent rate. Moreover, the group that used 500 ppm HAE demonstrated the highest level of performance in the investigation. Full article
(This article belongs to the Special Issue Phytochemical and Biological Activities of Natural Product with Application in Pharmacy and Food Technologies)
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15 pages, 4465 KiB  
Article
Involvement of GABAergic and Serotonergic Systems in the Antinociceptive Effect of Jegosaponin A Isolated from Styrax japonicus
by Lei He, Ying Zhou, Li Ma, Wencui Wang and Lei Yao
Molecules 2023, 28(5), 2243; https://doi.org/10.3390/molecules28052243 - 28 Feb 2023
Cited by 1 | Viewed by 1027
Abstract
The antinociceptive activity of the flower extracts of Styrax japonicus was confirmed in our previous study. However, the key compound for analgesia has not been distinguished, and the corresponding mechanism is obscure. In this study, the active compound was isolated from the flower [...] Read more.
The antinociceptive activity of the flower extracts of Styrax japonicus was confirmed in our previous study. However, the key compound for analgesia has not been distinguished, and the corresponding mechanism is obscure. In this study, the active compound was isolated from the flower by multiple chromatographic techniques and structurally illustrated using spectroscopic methods and referring to the related literature. The antinociceptive activity of the compound and the underlying mechanisms were investigated using animal tests. The active compound was determined to be jegosaponin A (JA), which showed significant antinociceptive responses. JA was also shown to possess sedative and anxiolytic activities but no anti-inflammatory effect, implying the association of the antinociceptive effects with the sedative and anxiolytic activities. Further antagonists and calcium ionophore tests showed that the antinociceptive effect of JA was blocked by flumazenil (FM, antagonist for GABA-A receptor) and reversed by WAY100635 (WAY, antagonist for 5-HT1A receptor). Contents of 5-HT and its metabolite (5-HIAA) increased significantly in the hippocampus and striatum tissues after JA administration. The results indicated that the antinociceptive effect of JA was regulated by the neurotransmitter system, especially GABAergic and serotonergic systems. Full article
(This article belongs to the Special Issue Phytochemical and Biological Activities of Natural Product with Application in Pharmacy and Food Technologies)
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