Submit to Special Issue Submit Abstract to Special Issue Review for Molecules Propose a Special Issue

Journal Menu

Journal Browser

Special Issue "Natural Secondary Metabolites III"

Special Issue Editors
Special Issue Information
Keywords
Related Special Issues
Published Papers

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 1791

Share This Special Issue

Special Issue Editors

Dr. Anna Andolfi

E-Mail Website1 Website2
Guest Editor

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo Via Cintia 4, I-80126 Naples, Italy
Interests: secondary metabolites in plant-pathogen interaction; natural substances with biological activity; chromatographic techniques; spectroscopic methods
Special Issues, Collections and Topics in MDPI journals

Dr. Maria Michela Salvatore

E-Mail Website
Guest Editor

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo Via Cintia 4, I-80126 Naples, Italy
Interests: isolation and structure elucidation of bioactive natural compounds from microorganisms and plants; chromatographic techniques; mass spectrometry; metabolomics

Special Issue Information

Dear Colleagues,

After the first two editions and considering the vigorous investigational activity on this intriguing topic, we can now announce with great pleasure the third edition of the Special Issue “Natural Secondary Metabolites”.

Since ancient times, secondary metabolites that are produced by plants, animals, fungi, and microorganisms have been used for their interesting properties as medical substances, poisons, dyes, antimicrobials, insecticides, flavoring substances, etc.

Several secondary metabolites mediate relationships between organisms, such as virulence factors, attractants for other useful organisms, defense factors, etc. Moreover, their distribution is often cross-species, as observed, for example, in plants and their endophytes. Finally, secondary metabolites show interesting action mechanisms and peculiar chemical properties.

The principal goal of this Special Issue is to cover all aspects of chemical and biotechnological relevance, such as extraction, identification, structural and stereostructural elucidation, biological activities, the rules of biotic and abiotic factors on secondary metabolites’ expressions, the development of analytical methods for their detection, and other related research.

Thus, this Special Issue aims to collect contributions from the field and provide a platform to make them more visible to the scientific community.

Dr. Anna Andolfi
Dr. Maria Michela Salvatore
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

structure and stereostructure elucidation
analytical techniques
optimization of growth conditions
dual culture method
biological activities
structure–activity relationship
biotic and abiotic factors on secondary metabolite production
chemical properties
metabolomics

Related Special Issues

Natural Secondary Metabolites in Molecules (15 articles)
Natural Secondary Metabolites II in Molecules (13 articles)

Published Papers (3 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Open AccessArticle

Comparative Analysis of Secondary Metabolites in Diplodia corticola Strains with Different Virulence Degrees Associated with Canker and Dieback of Quercus spp.

Maria Michela Salvatore

and

Molecules 2023, 28(17), 6302; https://doi.org/10.3390/molecules28176302 - 28 Aug 2023

Viewed by 326

Abstract

Diplodia corticola is one of the most aggressive fungal pathogens of Quercus species involved in the decline of Mediterranean oak forests. In this study, three strains of D. corticola associated with holm (Quercus ilex) and cork (Quercus suber) oak trees exhibiting dieback symptoms and cankers in Algeria were selected to investigate the production of secondary metabolites. Metabolomic analyses revealed the production of several known compounds, such as sphaeropsidins, diplopyrones and diplofuranones. Moreover, the comparative investigation of secondary metabolites produced by the analyzed strains with different degrees of virulence revealed possible implications of these compounds in the fungal virulence. In particular, sphaeropsidins seem to be the main phytotoxic compounds of D. corticola involved in the infections of Quercus species, with a possible synergistic influence of the less representative compounds in the fungal virulence. Full article

(This article belongs to the Special Issue Natural Secondary Metabolites III)

► Show Figures

Figure 1

Open AccessArticle

Effects of the Coculture Initiation Method on the Production of Secondary Metabolites in Bioreactor Cocultures of Penicillium rubens and Streptomyces rimosus

and

Molecules 2023, 28(16), 6044; https://doi.org/10.3390/molecules28166044 - 13 Aug 2023

Cited by 1 | Viewed by 586

Abstract

Bioreactor cocultures involving Penicillium rubens and Streptomyces rimosus were investigated with regard to secondary metabolite production, morphological development, dissolved oxygen levels, and carbon substrate utilization. The production profiles of 22 secondary metabolites were analyzed, including penicillin G and oxytetracycline. Three inoculation approaches were tested, i.e., the simultaneous inoculation of P. rubens with S. rimosus and the inoculation of S. rimosus delayed by 24 or 48 h relative to P. rubens. The delayed inoculation of S. rimosus into the P. rubens culture did not prevent the actinomycete from proliferating and displaying its biosynthetic repertoire. Although a period of prolonged adaptation was needed, S. rimosus exhibited growth and the production of secondary metabolites regardless of the chosen delay period (24 or 48 h). This promising method of coculture initiation resulted in increased levels of metabolites tentatively identified as rimocidin B, 2-methylthio-cis-zeatin, chrysogine, benzylpenicilloic acid, and preaustinoid D relative to the values recorded for the monocultures. This study demonstrates the usefulness of the delayed inoculation approach in uncovering the metabolic landscape of filamentous microorganisms and altering the levels of secondary metabolites. Full article

(This article belongs to the Special Issue Natural Secondary Metabolites III)

► Show Figures

Graphical abstract

Open AccessArticle

Chemical Compositions of Eupatorium heterophyllum Leaf Samples from Yunnan and Sichuan Provinces of China—Isolation of 13 New Sesquiterpene Lactones

and

Molecules 2023, 28(13), 5107; https://doi.org/10.3390/molecules28135107 - 29 Jun 2023

Viewed by 495

Abstract

Eight samples of Eupatorium heterophyllum leaves were collected at different locations in Yunnan and Sichuan provinces in China, and their chemical constituents were investigated. Thirteen previously undescribed sesquiterpene lactones—seven germacranolides, three eudesmanolides, two guaianolides, and a 2-norelemanolide—were isolated, and their structures were elucidated based on extensive spectroscopic analyses. The major constituents in the six samples from northwestern Yunnan and Sichuan are hiyodorilactones A and B, whereas that in the two samples from the region near Kunming, Yunnan is eupatoriopicrin. These results and previously reported results suggest the presence of locality-dependent intra-specific diversity in the chemical constituents of E. heterophyllum leaves. Full article

(This article belongs to the Special Issue Natural Secondary Metabolites III)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Natural Secondary Metabolites III"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Related Special Issues

Published Papers (3 papers)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI