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Analysis of Bioactive Compounds from Plants
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Analysis of Bioactive Compounds from Plants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 3690

Special Issue Editors

Dr. Nqobile Masondo

E-Mail Website
Guest Editor
Agricultural Research Council, Vegetable and Ornamental Plants (ARC-VOPI), Pretoria, South Africa
Interests: ethnobotany; biological activity; specialized metabolites
Dr. Keabetswe Masike

E-Mail Website
Guest Editor
Drug Discovery and Development (H3D) Centre, Department of Chemistry, University of Cape Town, Rondebosch, South Africa
Interests: plant natural products; LC-MS; metabolite characterisation; metabolomics; biological activity
Dr. Kannan RR Rengasamy

E-Mail Website
Guest Editor
Laboratory of Natural Products and Medicinal Chemistry (LNPMC), Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India
Interests: molecular pharmacology; enzyme inhibitors; marine natural
Dr. Msizi I. Mhlongo

E-Mail Website
Guest Editor
Research Centre for Plant Metabolomics, Department of Biochemistry, University of Johannesburg, Johannesburg, South Africa
Interests: plant metabolomics; analytical chemistry

Special Issue Information

Dear Colleagues,

Over the past decades, there has been a pressing need to synthesize and isolate interesting bioactive compounds with potential benefits in the pharmaceutical, cosmeceutical, agrochemical, flavor, and aroma industries. The bioprospecting of living organisms has become a useful system in the identification of natural resources able to produce novel bioactive compounds with remarkable pharmacological properties (antioxidant, antibacterial, anti-inflammatory, and antiviral), nutritional value, and cosmeceutical potential. Even with such diverse resources, a handful of isolated bioactive compounds or herbal extract formulations have been rigorously tested in clinical trials, i.e., pharmacological properties, efficacy, safety, and drug interactions. Targeted and/or untargeted analytical approaches combined with computational strategies are beneficial in uncovering and analyzing novel bioactive natural products.

The current Special Issue aims to profile bioactive compounds of natural origin and evaluate their pharmacological potential (in vitro, in vivo, or even clinical trials) as healthcare agents. A number of analytical techniques (e.g., HPLC, GC-MS, LC-MS, NMR, etc.) can be applied to profile, identify, and isolate the bioactive compounds of interest. We welcome submissions of original research, reviews, and methods directed towards the bioactive profile of novel compounds and their physiological/biological mechanisms in health.

Dr. Nqobile Masondo
Dr. Keabetswe Masike
Dr. Kannan RR Rengasamy
Dr. Msizi I. Mhlongo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • herbal extract formulation
  • volatile substances
  • analytical techniques
  • biological activity
  • bioavailability

Published Papers (2 papers)

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Research

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18 pages, 4867 KiB  
Article
The Prediction of Antioxidant Q-Markers for Angelica dahurica Based on the Dynamics Change in Chemical Compositions and Network Pharmacology
by Hui Gao and Qian Li
Molecules 2023, 28(13), 5248; https://doi.org/10.3390/molecules28135248 - 06 Jul 2023
Cited by 1 | Viewed by 1424
Abstract
Objective: To clarify the accumulation and mutual transformation patterns of the chemical components in Angelica dahurica (A. dahurica) and predict the quality markers (Q-Markers) of its antioxidant activity. Method: The types of and content changes in the chemical components in various [...] Read more.
Objective: To clarify the accumulation and mutual transformation patterns of the chemical components in Angelica dahurica (A. dahurica) and predict the quality markers (Q-Markers) of its antioxidant activity. Method: The types of and content changes in the chemical components in various parts of A. dahurica during different periods were analyzed by using gas chromatography-mass spectrometry technology (GC-MS). The antioxidant effect of the Q-Markers was predicted using network pharmacological networks, and molecular docking was used to verify the biological activity of the Q-Markers. Result: The differences in the content changes in the coumarin compounds in different parts were found by using GC-MS technology, with the relative content being the best in the root, followed by the leaves, and the least in the stems. The common components were used as potential Q-Markers for a network pharmacology analysis. The component-target-pathway-disease network was constructed. In the molecular docking, the Q-Markers had a good binding ability with the core target, reflecting better biological activity. Conclusions: The accumulation and mutual transformation patterns of the chemical components in different parts of A. dahurica were clarified. The predicted Q-Markers lay a material foundation for the establishment of quality standards and a quality evaluation. Full article
(This article belongs to the Special Issue Analysis of Bioactive Compounds from Plants)
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Review

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19 pages, 2440 KiB  
Review
Impacts of Binary Oxide Nanoparticles on the Soybean Plant and Its Rhizosphere, Associated Phytohormones, and Enzymes
by Titilope Tinu Ajiboye, Timothy Oladiran Ajiboye and Olubukola Oluranti Babalola
Molecules 2023, 28(3), 1326; https://doi.org/10.3390/molecules28031326 - 30 Jan 2023
Cited by 3 | Viewed by 1807
Abstract
The utilization of binary oxide nanoparticles is geometrically increasing due to their numerous applications. Their intentional or accidental release after usage has led to their omnipresence in the environment. The usage of sludge or fertilizer containing binary oxide nanoparticles is likely to increase [...] Read more.
The utilization of binary oxide nanoparticles is geometrically increasing due to their numerous applications. Their intentional or accidental release after usage has led to their omnipresence in the environment. The usage of sludge or fertilizer containing binary oxide nanoparticles is likely to increase the chance of the plants being exposed to these binary oxide nanoparticles. The aim of the present review is to assess the detailed positive and negative impacts of these oxide nanoparticles on the soybean plants and its rhizosphere. In this study, methods of synthesizing binary oxide nanoparticles, as well as the merits and demerits of these methods, are discussed. Furthermore, various methods of characterizing the binary oxide nanoparticles in the tissues of soybean are highlighted. These characterization techniques help to track the nanoparticles inside the soybean plant. In addition, the assessment of rhizosphere microbial communities of soybean that have been exposed to these binary oxide nanoparticles is discussed. The impacts of binary oxide nanoparticles on the leaf, stem, root, seeds, and rhizosphere of soybean plant are comprehensively discussed. The impacts of binary oxides on the bioactive compounds such as phytohormones are also highlighted. Overall, it was observed that the impacts of the oxide nanoparticles on the soybean, rhizosphere, and bioactive compounds were dose-dependent. Lastly, the way forward on research involving the interactions of binary oxide nanoparticles and soybean plants is suggested. Full article
(This article belongs to the Special Issue Analysis of Bioactive Compounds from Plants)
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