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Glycomimetics: Design, Synthesis and Bioorganic Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 429

Special Issue Editors

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Guest Editor
Dipartimento di Chimica "Ugo Schiff", Università degli Studi di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, FI, Italy
Interests: synthetic organic chemistry; carbohydrate-based glycomimetics; glycosidase inhibitors; iminosugar synthesis; lysosomal storage diseases; Gaucher disease; Parkinson disease
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Guest Editor
Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, 41012 Sevilla, Spain
Interests: synthetic organic chemistry; carbohydrates; glycosidase inhibitors; iminosugar synthesis; lysosomal storage diseases; lectins; multivalency; molecular recognition

Special Issue Information

Dear Colleagues,

Glycomimetics, as structurally altered analogues of sugars, offer the opportunity to mimic the biological action of carbohydrates while circumventing their drawbacks, and for this reason they are more and more promising as new drugs.

Structural modifications aim not only to enhance affinity and selectivity towards the biological target but also to improve their drug-like properties, which are important for their in vivo applications. Beyond their biological interest, glycomimetics are an amazing playground for organic chemists, since the syntheses are often highly challenging due to the presence of several chirality centers which give the researchers the opportunity to investigate new stereoselective reactions. In this regard, the chiral pool approach from carbohydrates is certainly the most straightforward and has the advantage of following one of the twelve principles of green chemistry (e.g. the use of renewable sources), but also highly innovative asymmetric syntheses were developed and they are also welcome.

In this Special Issue, which follows a Special Issue edited by Prof. Philippe Compain in 2018, we aim to collect reviews, original research articles and short communications covering all current aspects of glycomimetic chemistry, from innovative synthesis to potential bioorganic applications. Original research works on carbasugars, iminosugars, aminosugars, thiosugars, C- and N-glycosides, square sugars or other analogues are therefore welcome, whether these glycomimetics were designed for the synthetic challenges they provide, or for tackling fundamental questions in glycobiology, or for drug discovery.

Dr. Francesca Cardona
Dr. Macarena Martínez-Bailén
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • glycomimetics
  • glycosidase inhibition and/or enhancement
  • C- and N-glycosides
  • bioorganic chemistry
  • glycobiology

Published Papers

This special issue is now open for submission.
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