The Macrophages Role in Viral Infections
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 606
Interests: virus evolution; macrophages; HIV pathogenesis; antivirals; HIV chemotherapy; microbicides; viral resistance; neuroAIDS; mechanisms of virus entry; chemokines and chemokine receptors; role of astrocytes and neurons in HIV infection
Special Issues, Collections and Topics in MDPI journals
Macrophages play a crucial role in the pathogenesis and progression of virus-related infections. Different mechanisms and processes of viruses can establish acute, latent, or persistent infections in macrophages, and have been described and substantiated by in vitro and in vivo evidence. Indeed, macrophage receptors and intracellular pathways, cellular metabolism, and restriction factors, are involved in controlling the virus life cycle and tuning the cellular response to infection. Moreover, despite enhancing inflammation progression, infected macrophages generally display abolished apoptosis and restricted cytopathic effect, which sustains the virus’ production. At the same time, characterization of the macrophages mechanisms that interfere with viral replication and regulate the inflammatory cascade as well as identifying novel cellular targets for developing antivirals drugs and antiviral therapy approaches is a new challenge. All researchers working in the fields of human viral infections and macrophages are cordially invited to contribute original research papers or reviews to this Special Issue of Microorganisms.
Prof. Dr. Stefano Aquaro
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- virus receptors
- virus pathogenesis
- virus genome
- virus evolution
- virus entry
- virus replication
- viral enzymes
- drug design
- antiviral activity
- antiviral therapy
- antiviral resistance