Dear Colleagues,

Tuberculosis (TB) is a leading infectious disease killer worldwide and is only second to COVID-19. Mycobacterium tuberculosis, the pathogen that causes TB, has the ability to persist in its host and evade multiple antimicrobial mechanisms. M. tuberculosis infection can result in diverse clinical outcomes such as latent asymptomatic infection, active pulmonary disease, and extrapulmonary manifestations. Global efforts to eradicate TB are marred by an alarming increase in multi-drug resistant infections. Thus, there is a pressing need for an advanced understanding of this disease for the development of novel therapies. Recent years have seen substantial research investigating the impact of cellular metabolism on immunity with respect to M. tuberculosis. How host and pathogen influence cellular metabolism and how these interactions shape infection outcomes are poorly understood.

As the Guest Editor of this Special Issue, I invite you to submit original research articles, short communications, and review articles related to immunometabolism in M. tuberculosis pathogenesis. Research articles and short communications may describe metabolic dysfunction underlying inadequate immune responses to M. tuberculosis infection alone or during comorbidities, and metabolic perturbations and metabolites that enhance immunity against TB. Reviews should present the latest advancements in our understanding of immunometabolic crosstalk during M. tuberculosis infections and address gaps in current knowledge. Future investigations into this evolving discipline will contribute to an improved understanding of M. tuberculosis pathogenesis and aid in the development of TB therapies and biomarkers.

This Special Issue is jointly organized with the Special Issue “Mycobacterial Pathogenesis, Drug Resistance and Intervention Strategies“ in journal Medicina. 

Dr. Pallavi Chandra
Dr. Selvakumar Subbian
Guest Editors

Manuscript Submission Information

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• metabolism
• immunity
• immunometabolism
• tuberculosis, Mycobacterium tuberculosis