Dear Colleagues,

Helicobacter pylori (Hp) is a major human pathogen whose rampant antimicrobial resistance seriously threatens available therapeutic options. Important directions exist to counteract this situation: the implementation of new regimens (e.g., vonoprazan-based regimens, new antibiotics such as oxazolidinone analogues), the wider use of bismuth-containing regimens and adjuvants involving N-acetylcysteine and probiotics, anti-biofilm approaches using anti-biofilm peptides and rhamnolipids, and the development of vaccines against Hp. In addition to these interesting directions, the optimization of present eradication regimens is still conceivable with increased need of antimicrobial susceptibility testing, which is time-consuming, laborious, and unavailable in many countries. Fortunately, there is growing hope for non-invasive tests and whole-genome sequencing (WGS) methods for reliable drug resistance prediction in Hp. Elucidating molecular mechanisms and genetic attributes allowing Hp to survive antimicrobial insult is also a continuous quest.

The aim of this Special Issue is to give an overall picture of all aspects of antimicrobial resistance in Hp, with particular emphasis on innovative approaches to tackle resistance in clinical practice. For this purpose, we welcome the submission of research articles, review articles, and short communications related to the various aspects of antimicrobial resistance in Hp: molecular mechanisms, detection systems, epidemiology, Hp eradication regimens, and prevention and surveillance systems. We believe that this Special Issue will give an updated insight into the exciting field of Hp, and hope that it will bring new insights for research activities.

As Guest Editor of this Special Issue, I look forward to reviewing your submissions and, together, defining the present state of the science.

Prof. Dr. Yoshio Yamaoka
Guest Editor

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• Helicobacter pylori
• antimicrobial resistance
• whole-genome sequencing
• eradication therapy
• new regimens
• vaccines