Special Issue "Gram-Negative Bacterial Infections"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 202

Special Issue Editor

Dr. Nityananda Chowdhury
E-Mail Website
Guest Editor
Department of Oral Health Sciences, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425, USA
Interests: host-pathogen interactions; cellular microbiology; bacterial virulence and secretion systems; biology of bacterial persister/dormant cells; antibiotic persistence and resistance; bacterial evolution and pathogenicity; biofilm; gene regulation; functional genomics

Special Issue Information

Dear Colleagues,

The incidence of global infection caused by Gram-negative bacteria has significantly increased in recent years. Gram-negative bacteria contain lipopolysaccharides attached to their outer membranes; this constitutes a unique feature absent in Gram-positive bacteria. Among Gram-negative bacteria, pathogenic Escherichia coli, Vibrio cholerae, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Salmonella, Shigella, Yersinia, and Campylobacter are notable for their association with a wide range of serious infections, including urinary tract infections, diarrhea, pneumonia, bloodstream infections, wound or surgical site infections, and zoonotic infections. Several Gram-negative pathogens infect and colonize the gastrointestinal tract and hence are referred to as enteric pathogens. Additionally, oral microbiota have attained significant attention in recent years. This is especially the case for Porphyromonas gingivalis, a keystone opportunistic pathogen of oral mucosa, as this microorganism is not only the causative agent of chronic periodontitis but is also associated with several systemic diseases including Alzheimer’s disease, diabetes, and rheumatoid arthritis. Owing to their increasing resistance to multiple antibiotics, Gram-negative bacteria are great threats to public health and therefore major causes of morbidity and mortality world-wide. Additionally, biofilm and dormant or persister (antibiotic tolerant) bacteria are of major concerns as many, if not all, traditional antibiotics fail to eradicate them, and, therefore, they are associated with recalcitrant infections.  

Considering the global health crisis ongoing, substantial research efforts should be made to control infections with Gram-negative bacteria. This will require a comprehensive approach, including risk factor identification, virulence potential investigation, the use of advance methodologies for early detection/identification, and the implementation of infection control and prevention strategies. This Special Issue aims to publish original research and reviews in order to advance contributions in this important and timely research topic from the established and emerging experts in this field. Specifically, we aim to publish research related to any Gram-negative bacteria infection. As such, potential research areas include (but are not limited to) detection and diagnosis, antibiotic resistance, dormancy/perister cells, biofilm, new treatments or therapeutics, risk identification, and the prevention of Gram-negative bacteria infection. We look forward to receiving your contributions.

Dr. Nityananda Chowdhury
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Gram-negative bacteria
  • antibiotic resistance
  • identification
  • diagnosis
  • prevention
  • virulence
  • dormancy
  • antibiotic tolerance

Published Papers

This special issue is now open for submission.
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