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Microorganisms
Special Issues
Industrial Microbial Molecular Transformation and Application
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Industrial Microbial Molecular Transformation and Application

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5864

Special Issue Editor

Prof. Dr. Jianqiang Lin

E-Mail Website
Guest Editor
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China
Interests: applied molecular microbiology; biocatalysis and biotransformation; bioprocess engineering; modeling and simulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microorganisms are used to produce important industrial products in a more sustainable way in comparison with traditional chemical and energy-intensive processes. This Special Issue focuses on the rational manipulation of microbial systems and their enzymes through metabolic engineering techniques, genome editing, and recombinant technologies as well as bioinformatics and process systems engineering, fermentation technologies, bioreactor designs, and operations to provide new biocatalysts and microbial products and recovery. This Special Issue welcomes full-length original research papers, short communications, and review papers in the following research fields:

  • New biotechnological approaches in microbial genomics, proteomics, and metabolomics;
  • Microbial protein engineering, including enzyme engineering and directed evolution;
  • Biocatalysis (both enzyme or microbial) fermentation and bioreactor engineering, biotransformations, including immobilized biocatalyst preparation and kinetics;
  • Microbial production of specialty chemicals, bioactive molecules, biomaterials, biopharmaceuticals, etc.;
  • Bioresources and biorefinery engineering including microbial conversion of biomass, biofuels, bioenergy, and optimization.

Prof. Dr. Jianqiang Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetic engineering
  • recombinant microorganisms
  • biocatalysts
  • biotransformations
  • microbial and enzymatic bioproduction
  • bioprocess

Published Papers (1 paper)

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Review

21 pages, 1685 KiB  
Review
Glucose Transport in Escherichia coli: From Basics to Transport Engineering
by Ofelia E. Carreón-Rodríguez, Guillermo Gosset, Adelfo Escalante and Francisco Bolívar
Microorganisms 2023, 11(6), 1588; https://doi.org/10.3390/microorganisms11061588 - 15 Jun 2023
Cited by 6 | Viewed by 3991
Abstract
Escherichia coli is the best-known model for the biotechnological production of many biotechnological products, including housekeeping and heterologous primary and secondary metabolites and recombinant proteins, and is an efficient biofactory model to produce biofuels to nanomaterials. Glucose is the primary substrate used as [...] Read more.
Escherichia coli is the best-known model for the biotechnological production of many biotechnological products, including housekeeping and heterologous primary and secondary metabolites and recombinant proteins, and is an efficient biofactory model to produce biofuels to nanomaterials. Glucose is the primary substrate used as the carbon source for laboratory and industrial cultivation of E. coli for production purposes. Efficient growth and associated production and yield of desired products depend on the efficient sugar transport capabilities, sugar catabolism through the central carbon catabolism, and the efficient carbon flux through specific biosynthetic pathways. The genome of E. coli MG1655 is 4,641,642 bp, corresponding to 4702 genes encoding 4328 proteins. The EcoCyc database describes 532 transport reactions, 480 transporters, and 97 proteins involved in sugar transport. Nevertheless, due to the high number of sugar transporters, E. coli uses preferentially few systems to grow in glucose as the sole carbon source. E. coli nonspecifically transports glucose from the extracellular medium into the periplasmic space through the outer membrane porins. Once in periplasmic space, glucose is transported into the cytoplasm by several systems, including the phosphoenolpyruvate-dependent phosphotransferase system (PTS), the ATP-dependent cassette (ABC) transporters, and the major facilitator (MFS) superfamily proton symporters. In this contribution, we review the structures and mechanisms of the E. coli central glucose transport systems, including the regulatory circuits recruiting the specific use of these transport systems under specific growing conditions. Finally, we describe several successful examples of transport engineering, including introducing heterologous and non-sugar transport systems for producing several valuable metabolites. Full article
(This article belongs to the Special Issue Industrial Microbial Molecular Transformation and Application)
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