Antimicrobial Resistance Transfer from Animal to Environment

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Public Health Microbiology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 5299

Special Issue Editors

Department of Biology, Maynooth University, Maynooth, Ireland
Interests: antimicrobial resistance; one health; genomics; metagenomics; plasmids
Department of Biology, Maynooth University, Maynooth, Ireland
Interests: metagenomics; antimicrobial resistance; evolution; bioinformatics

Special Issue Information

Dear Colleagues,

This topic covers a wide array of animals (including birds and fish) and how they influence the movement of the resistome into and across different environments. Research on the transfer of AMR (bacterial, fungal, and viral) to date has focused on manure from food animals and its spread to the soil. This Special Issue will build on that knowledge and expand it to areas for which there is less knowledge. In particular, we encourage submissions focussing on countries for which there is little data on AMR transmission, areas with few examples of its transmission, and novel aspects of previously discussed topics. Topics can include but are not limited to:

  • Wildlife as a reservoir of AMR transfer to the environment;
  • Solutions or interventions to prevent the transfer of AMR from animals to the environment;
  • Manure as a medium for the movement of AMR from food animals to the environment;
  • Tracking the movement of AMR from animals to the environment;
  • The movement of mobile elements containing AMR across animal microbiomes and the environment;
  • Modelling the transfer of AMR from animals to the environment
  • The transportation of animals and manure internationally: what is the risk?
  • Methods for analyzing the transfer of AMR from animals to the environment.

Dr. Fiona Walsh
Dr. Robert Leigh
Guest Editors

Manuscript Submission Information

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Keywords

  • mobility
  • antibiotics
  • transmission
  • water
  • soil
  • plants
  • feces
  • food
  • wildlife
  • plasmid
  • risk
  • intervention

Published Papers (2 papers)

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Research

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12 pages, 317 KiB  
Article
On-Farm Practices Associated with Multi-Drug-Resistant Escherichia coli and Vibrio parahaemolyticus Derived from Cultured Fish
by Rita Rosmala Dewi, Latiffah Hassan, Hassan Mohammad Daud, Mohd. Fuad Matori, Zunita Zakaria, Nur Indah Ahmad, Saleha A. Aziz and Saleh Mohammed Jajere
Microorganisms 2022, 10(8), 1520; https://doi.org/10.3390/microorganisms10081520 - 27 Jul 2022
Cited by 2 | Viewed by 1543
Abstract
Aquaculture activities have been implicated as responsible for the emergence of antimicrobial resistance (AMR), leading to broad dissemination and transference of antibiotic resistance to pathogens that affect humans and animals. The current study investigates the on-farm practices and environmental risk factors that can [...] Read more.
Aquaculture activities have been implicated as responsible for the emergence of antimicrobial resistance (AMR), leading to broad dissemination and transference of antibiotic resistance to pathogens that affect humans and animals. The current study investigates the on-farm practices and environmental risk factors that can potentially drive the development and emergence of multi-drug-resistant (MDR) Escherichia coli and Vibrio parahaemolyticus in the aquaculture system. A cross-sectional study was conducted on 19 red hybrid tilapia (Oreochromis spp.) and 13 Asian seabass (Lates calcarifer, Bloch 1970) farms on the west coast of peninsular Malaysia. Data were collected using a structured questionnaire pertaining to farm demography, on-farm management practices and environmental characteristics. Multi-drug-resistant E. coli (n = 249) and V. parahaemolyticus (n = 162) isolates were analyzed using multi-level binary logistic regression to identify important drivers for the occurrence and proliferation of the MDR bacteria. On-farm practices such as manuring the pond (OR = 4.5; 95% CI = 1.21–16.57) were significantly associated with the occurrence of MDR E. coli, while earthen ponds (OR = 8.2; 95% CI = 1.47–45.2) and human activity adjacent to the farm (OR = 4.6; 95% CI = 0.75–27.98) were associated with an increased likelihood of MDR V. parahaemolyticus. Considering the paucity of information on the drivers of AMR in the aquaculture production in this region, these findings indicate the targeted interventions implementable at aquaculture farms to efficiently abate the risk of MDR amongst bacteria that affect fish that are of public health importance. Full article
(This article belongs to the Special Issue Antimicrobial Resistance Transfer from Animal to Environment)

Review

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13 pages, 648 KiB  
Review
Epidemiology and Traits of Mobile Colistin Resistance (mcr) Gene-Bearing Organisms from Horses
by Madubuike Umunna Anyanwu, Ishmael Festus Jaja, Obichukwu Chisom Nwobi, Anthony Christian Mgbeahuruike, Chinaza Nnenna Ikpendu, Nnenna Audrey Okafor and James Wabwire Oguttu
Microorganisms 2022, 10(8), 1499; https://doi.org/10.3390/microorganisms10081499 - 25 Jul 2022
Cited by 4 | Viewed by 3332
Abstract
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) threaten the efficacy of colistin (COL), a polymyxin antibiotic that is used as a last-line agent for the treatment of deadly infections caused by multidrug-resistant and extensively drug-resistant bacteria in [...] Read more.
Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) threaten the efficacy of colistin (COL), a polymyxin antibiotic that is used as a last-line agent for the treatment of deadly infections caused by multidrug-resistant and extensively drug-resistant bacteria in humans and animals. COL has been used for more than 60 years for the prophylactic control and treatment of infections in livestock husbandry but not in horses. Polymyxin B is used for the prophylactic control and empirical treatment of infections in horses without conducting sensitivity tests. The lack of sensitivity testing exerts selection pressure for the acquisition of the mcr gene. By horizontal transfer, mcr-1, mcr-5, and mcr-9 have disseminated among horse populations globally and are harbored by Escherichia coli, Klebsiella, Enterobacter, Citrobacter, and Salmonella species. Conjugative plasmids, insertion sequences, and transposons are the backbone of mcr genes in the isolates, which co-express genes conferring multi- to extensive-drug resistance, including genes encoding extended-spectrum β-lactamase, ampicillinase C, fosfomycin, and fluoroquinolone resistance, and virulence genes. The transmission of mcr genes to/among bacterial strains of equine origin is non-clonal. Contact with horses, horse manure, feed/drinking water, farmers, farmers’ clothing/farm equipment, the consumption of contaminated horse meat and its associated products, and the trading of horses, horse meat, and their associated products are routes for the transmission of mcr-gene-bearing bacteria in, to, and from the equine industry. Full article
(This article belongs to the Special Issue Antimicrobial Resistance Transfer from Animal to Environment)
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