Special Issue "Actinobacteria and Myxobacteria—Important Resources for Novel Antibiotics"
Deadline for manuscript submissions: closed (30 April 2018) | Viewed by 39309
A printed edition of this Special Issue is available here.
Interests: polyphasic taxonomy; cultivation methods; isolation methods; taxonomy and secondary metabolites from Actinobacteria and Myxobacteria; morphology and fine structure of Actinobacteria and Myxobacteria
Special Issues, Collections and Topics in MDPI journals
Bacterial infections cause millions of deaths globally, particularly in children and the elderly, and four of the 10 leading causes of death are infectious diseases in low- and middle-income countries. The continuous use of antibiotics has resulted in multi-resistant bacterial strains all over the world, such as Community-associated Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamases (ESBLs), and, as expected, hospitals have become breeding grounds for human-associated microorganisms, especially in critical care units.
Natural products are the bedrock and a valuable source for drug discovery programs. More than 60% of the drugs that are available on the market are derived from natural sources. Many antibiotics are made chemically via modification of natural products through a process called semi synthesis. Natural product structures have the characteristics of a high chemical diversity, biochemical specificity, and high binding affinities to their specific receptor and also interact with a wide variety of biological targets.
Microorganisms produce a wide range of natural products, which are used as lead components in the drug discovery era. Over 6000 compounds of microbial origin with anti-microbial activities have been isolated. The microbial world represents 90% of all biological diversity and less than 1% has presently been explored (Molinari 2009). Mining microbial diversity is the key to obtaining high compound diversity, because a very large source for new natural products remains unexplored. To date, a few groups of microorganisms have been known to be high and potent producers of natural products: Actinomycetes, Bacillus, cyanobacteria, fungi and myxobacteria.
Dr. Joachim Wink
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- Polyphasic Taxonomy
- Secondary Metabolites
- PKS and NRPS