Infection Diseases and Chronic Health Conditions

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Public Health Microbiology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 789

Special Issue Editor

Department of Metabolic Diseases and Clinical Genetics, Giovanni XXIII Children Hospital, Azienda Ospedaliero-Universitaria Consorziale Policlinico, 70126 Bari, Italy
Interests: pediatrics;clinical genetics;inherited metabolic disorders;newborn screening;phenylketonuria
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Special Issue Information

Dear Colleagues,

Chronic conditions represent a broad spectrum of chronic and complex health conditions, both communicable and non-communicable. Although it is common to approach chronic and infectious diseases as having completely distinct aetiologies and approach, there is an increasing acknowledgement for a closer relationship between them. In this context, COVID-19 has emphasized even more the existence of common determinants that underlie both.

Rather than discussing the role of infections as major determinants of chronic diseases, this Special Issue aims at focusing on the complex and bidirectional relationship between these two apparently distinguished groups of disorders.

There are several reasons why an infection may be associated with a chronic condition: the infection may be more prevalent in patients with the chronic disease (for a compromised immune response); the pathogen increases the risk of getting the disease, or causes the disease only when combined with other causal factors (genetic factors, or toxic exposure). Infection (such as seasonal influenza) may occur in the background of an established chronic disease and interact with it, modifying its natural history (increasing the risk of hospital admissions and death). Pathogens can also cause an “immunologic scarring” even after resolution, accounting for a wide range of chronic effects.

More studies on interactions between infections and chronic diseases might help to understand and optimize the management of both and would help to apply pharmacologic approaches that are able to manage chronic diseases while treating infections.

Dr. Albina Tummolo
Guest Editor

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Keywords

  • infections
  • chronic conditions
  • genetic diseases
  • immune system
  • virus

Published Papers (1 paper)

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Review

13 pages, 468 KiB  
Review
The Reciprocal Interplay between Infections and Inherited Metabolic Disorders
Microorganisms 2023, 11(10), 2545; https://doi.org/10.3390/microorganisms11102545 - 12 Oct 2023
Viewed by 597
Abstract
Infections represent the main cause of acute metabolic derangements and/or the worsening of the clinical course of many inherited metabolic disorders (IMDs). The basic molecular mechanisms behind the role of infections in these conditions have not been completely clarified. This review points out [...] Read more.
Infections represent the main cause of acute metabolic derangements and/or the worsening of the clinical course of many inherited metabolic disorders (IMDs). The basic molecular mechanisms behind the role of infections in these conditions have not been completely clarified. This review points out the different mechanisms behind the relationship between IMDs and infections, providing an overview of this still-under-investigated area. Classically, infections have been considered as the consequence of a compromised immune system due to a biochemical defect of energy production. An adjunctive pathogenetic mechanism is related to a genetically altered protein-attached glycans composition, due to congenital glycosilation defects. In addition, a dietary regimen with a reduced intake of both micro- and macronutrients can potentially compromise the ability of the immune system to deal with an infection. There is recent pre-clinical evidence showing that during infections there may be a disruption of substrates of various metabolic pathways, leading to further cellular metabolic alteration. Therefore, infective agents may affect cellular metabolic pathways, by mediation or not of an altered immune system. The data reviewed here strongly suggest that the role of infections in many types of IMDs deserves greater attention for a better management of these disorders and a more focused therapeutic approach. Full article
(This article belongs to the Special Issue Infection Diseases and Chronic Health Conditions)
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