Streptomyces and Biosynthesis
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3921
Special Issue Editors
Interests: secondary metabolites biosynthesis; genetics and genomics of actinobacteria; metabolic engineering of actinobacteria
Interests: bacterial genetics; with a focus on antibiotic-producing actinobacteria; regulation of antibiotics biosynthesis; codon-based mechanisms of regulation of gene expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Actinobacteria, and particularly the Streptomyces genus, remain one of the major sources of natural products. The advances in genome sequencing and analysis accompanied with tools and approaches for cloning and activating biosynthetic gene clusters changed the paradigm of the discovery of bacterial natural products. The classic way “from compound to gene” is now reversed. This facilitated the identification of metabolites with new structures and biosynthetic pathways, often involving new biochemistry, by cloning and manipulating gene clusters.
This Special Issue of Microorganisms aims to present a collection of articles describing the structural diversity of natural products of actinobacterial origin with a specific focus on respective biosynthetic pathways, covering the assembly of new compounds and their modification reactions. We also welcome reviews dedicated to the topic of this Special Issue, as well as research articles covering the activation of cryptic biosynthetic gene clusters and the regulation of specialized metabolism in actinobacteria.
Dr. Yuriy V. Rebets
Dr. Bohdan Ostash
Guest Editors
Manuscript Submission Information
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Keywords
- actinobacteria
- streptomyces
- secondary metabolites
- specialized metabolites
- antibiotics
- biosynthetic gene cluster
- biosynthetic pathway
