Special Issue "Lifestyle, Gut Microbiota and Health, 2nd Edition"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 15 September 2023 | Viewed by 920

Special Issue Editor

Chronic Diseases Research Center (CEDOC)/NOVA Medical School, Universidade NOVA de Lisboa, 1180-052, 1150-082 Lisbon, Portugal
Interests: gut microbiota; gut microbiome; iron metabolism; heme biology; inflammation; infections and neurodegeneration
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Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue "Lifestyle, Gut Microbiota and Health”.

The gut microbiome has opened a new horizon in nutrition and biomedical research by being implicated in metabolic diseases such as obesity, diabetes, and hypertension, among others. These diseases are also influenced by lifestyle factors such as dietary habits and exercise, which in turn can modify the composition of the gut microbiome. Thus, the gut microbiome can be considered an intermediary of the effects of diet and exercise on metabolic health, assuming a special relevance in the prevention, treatment, and monitoring of these diseases.

Diet is one of the most important factors that can modulate the gut microbiome and rapidly induce alterations in its composition. Some dietary components such as fiber and phytochemicals, as well as fermented foods (yogurt, kefir, wine, beer, etc.), may stimulate the growth of or contain microorganisms that confer health benefits to the host. On the other hand, diet is also a source of exposure to environmental contaminants where the activity of endocrine disruptors may be mediated by gut microbiota modulation.

Recently, physical activity and exercise have been shown to beneficially modulate gut microbiota composition, increasing the relevance of these lifestyle factors in health.

The aim of this Special Issue is to gather more information on how our lifestyle, including diet and exercise, affect the gut microbiome and how this is associated with health. Therefore, I welcome researchers to submit their research or review articles on this topic.

Dr. Raffaella Gozzelino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • lifestyle
  • diet
  • Mediterranean diet
  • physical activity
  • exercise
  • polyphenols
  • prebiotics
  • gut microbiota
  • gut microbiome

Published Papers (1 paper)

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Research

Article
Gut Dysbiosis: A Target for Protective Interventions against Parkinson’s Disease
Microorganisms 2023, 11(4), 880; https://doi.org/10.3390/microorganisms11040880 - 29 Mar 2023
Cited by 1 | Viewed by 851
Abstract
Sub-chronic inflammation, caused by age-related dysbiosis, primes the brain to neuroinflammation and neurodegenerative diseases. Evidence revealed that Parkinson’s disease (PD) might originate in the gut, demonstrating gastro-intestinal disturbances, as reported by PD patients long before developing motor symptoms. In this study, we conducted [...] Read more.
Sub-chronic inflammation, caused by age-related dysbiosis, primes the brain to neuroinflammation and neurodegenerative diseases. Evidence revealed that Parkinson’s disease (PD) might originate in the gut, demonstrating gastro-intestinal disturbances, as reported by PD patients long before developing motor symptoms. In this study, we conducted comparative analyses in relatively young and old mice maintained in conventional or gnotobiotic conditions. We aimed to confirm that the effects induced by age-related dysbiosis, rather than aging itself, sensitize to PD onset. This hypothesis was confirmed in germ-free (GF) mice, which proved resistant to the pharmacological induction of PD, regardless of their age. Contrary to conventional animals, old GF mice did not develop an inflammatory phenotype or an accumulation of iron in the brain, two catalysts sensitizing to disease onset. The resistance of GF mice to PD is reverted when colonized with stool collected from conventional old animals, but not if receiving bacterial content from young mice. Hence, changes in gut microbiota composition are a risk factor for PD development and can be targeted preventively by iron chelators, shown to protect the brain from pro-inflammatory intestinal priming that sensitizes to neuroinflammation and the development of severe PD. Full article
(This article belongs to the Special Issue Lifestyle, Gut Microbiota and Health, 2nd Edition)
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