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Microorganisms
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Antibiotic-Resistant Enterobacterales at the Human–Animal–Environment Interface
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Antibiotic-Resistant Enterobacterales at the Human–Animal–Environment Interface

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 7626

Special Issue Editors

Dr. Timo Homeier-Bachmann

E-Mail Website
Guest Editor
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, 17493 Greifswald-Insel Riems, Germany
Interests: extended spectrum beta-lactamase; Enterobacterales; epidemiology; risk factors; livestock; wildlife; environment
Prof. Dr. Katharina Schaufler

E-Mail Website
Guest Editor
1. Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany
2. Institute of Infection Medicine, Christian-Albrecht University and University Medical Center Schleswig-Holstein, 24103 Kiel, Germany
Interests: MDR; Enterobacterales; plasmids; successful sequence types and their drivers; virulence; one health

Special Issue Information

Dear Colleagues,

Antimicrobial resistance is a serious threat to humans and animals with high societal relevance. While antibiotic-resistant (ABR) bacteria have been frequently described in clinical settings and livestock husbandry, less is known about their distribution in wildlife and the environment—especially regarding risk factors that drive their emergence. Due to limited treatment possibilities, ABR representatives belonging to the Enterobacterales that exhibit extended-spectrum beta-lactamases (ESBLs), carbapenemases and/or colistin resistance are among the most critical.

This Special Issue focuses on the epidemiology, risk factors and drivers, and transmission of ABR Enterobacterales, particularly at the human–animal–environment interface, and thus the One Health context. This may for example include studies on the prevalence; distribution and epidemiology; molecular characterization, including antibiotic/disinfectant/heavy-metal resistance features; fitness and virulence; as well as transmission across different settings of these bacteria.

Dr. Timo Homeier-Bachmann
Prof. Dr. Katharina Schaufler
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic-resistant Enterobacterales
  • epidemiology
  • risk factors
  • successful sequence types and their drivers
  • one health

Published Papers (3 papers)

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Research

14 pages, 25068 KiB  
Article
Epidemiological Characterisation of blaNDM-Positive Enterobacterales from Food-Producing Animal Farms in Southwest China
by Renqiao Wen, Hongcheng Wei, Tiejun Zhang, Peng Ma, Qin Wang, Chao Li, Zhonghan Li, Changwei Lei and Hongning Wang
Microorganisms 2023, 11(9), 2304; https://doi.org/10.3390/microorganisms11092304 - 13 Sep 2023
Viewed by 1023
Abstract
Carbapenems are atypical β-lactam antibiotics with a broade antibacterial spectrum and strong antibacterial activity; however, the emergence and spread of carbapenemases have led to a decline in their effectiveness. New Delhi metallo-β-lactamase (NDM) is an important carbapenemase that has attracted widespread attention and [...] Read more.
Carbapenems are atypical β-lactam antibiotics with a broade antibacterial spectrum and strong antibacterial activity; however, the emergence and spread of carbapenemases have led to a decline in their effectiveness. New Delhi metallo-β-lactamase (NDM) is an important carbapenemase that has attracted widespread attention and poses a major threat to public health. To investigate the epidemiological characteristics of blaNDM in swine and chicken farms in southwestern China, we isolated 102 blaNDM-positive Enterobacterales strains from 18 farms in Sichuan and Yunnan provinces in 2021, with Escherichia coli and Klebsiella spp. being the main reservoirs of blaNDM, variant blaNDM-5 being the most prevalent, and all strains being multi-drug resistant. Whole-genome sequencing analysis of 102 blaNDM-positive Enterobacterales strains revealed that blaNDM had spread primarily through its carriers on the same farm and among the 18 farms in this study. A high degree of genetic similarity between animal-derived blaNDM-positive Escherichia coli strains and human-derived strains was also identified, suggesting a potential mutual transmission between them. Nanopore sequencing results indicated that blaNDM is predominantly present on the IncX3 plasmid, that an insertion sequence might be important for recombination in the blaNDM genetic environment, and that most of the plasmids carrying blaNDM are transferable. Collectively, our results enrich the current epidemiological information regarding blaNDM in pig and chicken farms in Southwest China, revealing its transmission pattern, as well as the potential risk of transmission to humans, which could help to better understand and control the spread of blaNDM. Full article
(This article belongs to the Special Issue Antibiotic-Resistant Enterobacterales at the Human–Animal–Environment Interface)
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16 pages, 636 KiB  
Article
Identification and Characterization of Antibiotic-Resistant, Gram-Negative Bacteria Isolated from Korean Fresh Produce and Agricultural Environment
by Sunyoung Jeong, Ile Kim, Bo-Eun Kim, Myeong-In Jeong, Kwang-Kyo Oh, Gyu-Sung Cho and Charles M. A. P. Franz
Microorganisms 2023, 11(5), 1241; https://doi.org/10.3390/microorganisms11051241 - 08 May 2023
Cited by 1 | Viewed by 4451
Abstract
The consumption of fresh produce and fruits has increased over the last few years as a result of increasing consumer awareness of healthy lifestyles. Several studies have shown that fresh produces and fruits could be potential sources of human pathogens and antibiotic-resistant bacteria. [...] Read more.
The consumption of fresh produce and fruits has increased over the last few years as a result of increasing consumer awareness of healthy lifestyles. Several studies have shown that fresh produces and fruits could be potential sources of human pathogens and antibiotic-resistant bacteria. In this study, 248 strains were isolated from lettuce and surrounding soil samples, and 202 single isolates selected by the random amplified polymorphic DNA (RAPD) fingerprinting method were further characterized. From 202 strains, 184 (91.2%) could be identified based on 16S rRNA gene sequencing, while 18 isolates (8.9%) could not be unequivocally identified. A total of 133 (69.3%) and 105 (54.7%) strains showed a resistance phenotype to ampicillin and cefoxitin, respectively, while resistance to gentamicin, tobramycin, ciprofloxacin, and tetracycline occurred only at low incidences. A closer investigation of selected strains by whole genome sequencing showed that seven of the fifteen sequenced strains did not possess any genes related to acquired antibiotic resistance. In addition, only one strain possessed potentially transferable antibiotic resistance genes together with plasmid-related sequences. Therefore, this study indicates that there is a low possibility of transferring antibiotic resistance by potential pathogenic enterobacteria via fresh produce in Korea. However, with regards to public health and consumer safety, fresh produce should nevertheless be continuously monitored to detect the occurrence of foodborne pathogens and to hinder the transfer of antibiotic resistance genes potentially present in these bacteria. Full article
(This article belongs to the Special Issue Antibiotic-Resistant Enterobacterales at the Human–Animal–Environment Interface)
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15 pages, 1041 KiB  
Article
Longitudinal Study on Extended-Spectrum Beta-Lactamase-E. coli in Sentinel Mallard Ducks in an Important Baltic Stop-Over Site for Migratory Ducks in Germany
by Sylvia Dreyer, Anja Globig, Lisa Bachmann, Anne K. Schütz, Katharina Schaufler and Timo Homeier-Bachmann
Microorganisms 2022, 10(10), 1968; https://doi.org/10.3390/microorganisms10101968 - 05 Oct 2022
Cited by 2 | Viewed by 1677
Abstract
Antimicrobial resistance (AMR) is a serious global health threat with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales as the most critical ones. Studies on AMR in wild birds imply a possible dissemination function and indicate their potential role as sentinel animals. This study aimed to gain [...] Read more.
Antimicrobial resistance (AMR) is a serious global health threat with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales as the most critical ones. Studies on AMR in wild birds imply a possible dissemination function and indicate their potential role as sentinel animals. This study aimed to gain a deeper insight into the AMR burden of wild waterfowl by sampling semi-wild mallard ducks used as sentinels and to identify if AMR bacteria could be recommended to be added to the pathogens of public health risks to be screened for. In total, 376 cloacal and pooled fecal samples were collected from the sentinel plant over a period of two years. Samples were screened for ESBL-carrying E. coli and isolates found further analyzed using antimicrobial susceptibility testing and whole-genome sequencing. Over the sampling period, 4.26% (16/376) of the samples were positive for ESBL-producing E. coli. BlaCTX-M-1 and blaCTX-M-32 were the most abundant CTX-M types. Although none of the top global sequence types (ST) could be detected, poultry-derived ST115 and non-poultry-related STs were found and could be followed over time. The current study revealed low cases of ESBL-producing E. coli in semi-wild mallard ducks, which proves the suitability of sentinel surveillance for AMR detection in water-associated wildlife. Full article
(This article belongs to the Special Issue Antibiotic-Resistant Enterobacterales at the Human–Animal–Environment Interface)
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