Advances in Genetics, Physiology, and Metabolism of Streptomyces

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1533

Special Issue Editors


E-Mail Website
Guest Editor
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
Interests: secondary metabolite production improvement; biotech applications; Antarctic bacteria; Streptomyces
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90128 Palermo, Italy
Interests: streptomycetes; secondary metabolite production improvement; biotech applications; bacterial extracellular vesicles

Special Issue Information

Dear Colleagues,

Bacteria belonging to the genus Streptomyces represent a remarkable source of natural compounds having diverse functions, such as antibiotics, antivirals, antifungals, and antitumorals. Research on metabolism of Streptomyces is of great interest these days more than ever: indeed, for example, lack of bioactive compounds able to contrast multi-drug resistant pathogens is a serious threat and needs the quick discovery of new effective molecules.

Besides having a great potential for the development of novel biotechnological applications, some of them are also useful models for the study of morpho-physiological differentiation in bacteria and the production of specialized metabolites. Indeed, streptomycetes have complex development programs which lead to the formation of specialized cell types and that are regulated by both endogenous and environmental signals. Moreover, these physiological aspects of their life cycles are usually strictly related to the production of their metabolites.

This Special Issue is addressed especially to the international scientific community working with streptomycetes, and its aim is to collect manuscripts on the most recent advances regarding genetics, physiology, metabolism, and biotechnology applications of Streptomyces bacteria. As Guest Editors of this Special Issue, we invite you to submit research articles, review articles, and short communications related to these fascinating and still untapped microorganisms.

Dr. Alberto Vassallo
Dr. Teresa Faddetta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • streptomyces
  • genetics
  • physiology
  • metabolism
  • bioactive compounds
  • antibiotics
  • biotechnology
  • genetic engineering

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 4682 KiB  
Article
Biotechnological Production and Characterization of Extracellular Melanin by Streptomyces nashvillensis
by Odile Francesca Restaino, Paola Manini, Talayeh Kordjazi, Maria Laura Alfieri, Massimo Rippa, Loredana Mariniello and Raffaele Porta
Microorganisms 2024, 12(2), 297; https://doi.org/10.3390/microorganisms12020297 - 30 Jan 2024
Cited by 1 | Viewed by 906
Abstract
Melanins are pigments employed in food, cosmetic, and textile industries, manufactured by extraction from cuttlefishes. Their biotechnological production by Streptomycetes, instead, has been poorly investigated so far. In this paper, for the first time, the strain Streptomyces nashvillensis DSM 40314 was tested as [...] Read more.
Melanins are pigments employed in food, cosmetic, and textile industries, manufactured by extraction from cuttlefishes. Their biotechnological production by Streptomycetes, instead, has been poorly investigated so far. In this paper, for the first time, the strain Streptomyces nashvillensis DSM 40314 was tested as an extracellular melanin producer by investigating the influence of diverse temperatures (26, 28, and 30 °C) and pH values (6.0 and 7.0) on bacterial growth, melanin production, and on the activity of the secreted tyrosinase, the first enzyme of the pigment biosynthetic pathway. In physiological 96-h shake flask experiments, the optimal growth parameters resulted to be 28 °C and pH 7.0, at which a maximum biomass of 8.4 ± 0.5 gcdw/L, a melanin concentration of 0.74 ± 0.01 g/L (yield on biomass of 0.09 ± 0.01 g/gcdw and productivity of 0.008 ± 0.001 g/L/h), and a final tyrosinase activity of 10.1 ± 0.1 U/mL were reached. The produced pigment was purified from the broth supernatant with a two-step purification process (75.0 ± 2.0% of purity with 65.0 ± 5.0% of recovery) and tested for its chemical, antioxidant, and photoprotective properties. Finally, characterization by UV-visible and FT-IR spectroscopy, elemental analyses, and mono- and bi-dimensional NMR suggested the eumelanin-like nature of the pigment. Full article
(This article belongs to the Special Issue Advances in Genetics, Physiology, and Metabolism of Streptomyces)
Show Figures

Graphical abstract

Back to TopTop