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Microorganisms
Special Issues
Spreading Monkeypox Virus: Characterization, Epidemiology, and Foreseeable Outcome
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Spreading Monkeypox Virus: Characterization, Epidemiology, and Foreseeable Outcome

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1447

Special Issue Editor

Prof. Dr. Antonella d'Arminio Monforte

E-Mail Website
Guest Editor
1. Icona Foundation, 20142 Milan, Italy
2. Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, 20142 Milan, Italy
Interests: liver diseases; HIV infection; HIV prevention; tuberculosis; clinical infectious diseases; infectious disease epidemiology; mycobacterium tuberculosis; viral infection; immunology of infectious diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently increasing cases of Human Monkey Pox Virus diseases have been diagnosed in several countries. Most of them are very apparently non-related, and most of them occurred among MSM.

Several grey areas and open questions could be addressed in a Special Issue of Microorganisms:

  • Way of transmission: the role of others than sexual transmission
  • Course of the disease according to host-related variables (age, sex, genetics…)
  • Prevalence and clinical course of MPV among PLWH
  • Response to antivirals
  • Role of vaccination for Pox virus in preventing MPV

Prof. Dr. Antonella d'Arminio Monforte
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

8 pages, 608 KiB  
Article
Performance of a Novel Real-Time PCR-Based Assay for Rapid Monkeypox Virus Detection in Human Samples
by Flora Marzia Liotti, Simona Marchetti, Federico Falletta, Sara D’Onghia, Maurizio Sanguinetti, Rosaria Santangelo and Brunella Posteraro
Microorganisms 2023, 11(10), 2513; https://doi.org/10.3390/microorganisms11102513 - 08 Oct 2023
Cited by 1 | Viewed by 1044
Abstract
The ongoing epidemic of mpox, namely human monkeypox virus (MPXV) infection, requires rapid and reliable laboratory diagnosis. We report on the QIAstat-Dx viral vesicular panel PCR assay that allows the detection of (within 75 min) six vesicular disease-causing viruses, including MPXV. We analyzed [...] Read more.
The ongoing epidemic of mpox, namely human monkeypox virus (MPXV) infection, requires rapid and reliable laboratory diagnosis. We report on the QIAstat-Dx viral vesicular panel PCR assay that allows the detection of (within 75 min) six vesicular disease-causing viruses, including MPXV. We analyzed 168 clinical samples, known to be positive (51 samples) or negative (117 samples) for MPXV clade II, obtained from patients at their mpox diagnosis or follow-up. QIAstat assay results were compared to those of a MPXV-specific reference PCR assay. The QIAstat assay detected MPXV (clade II) in 51 (100%) of 51 samples and did not detect MPXV in 117 (100%) of 117 samples, resulting in a positive or negative agreement of 100% (95% CI, 93.0–100) and 100% (95% CI, 96.8–100), respectively. Of the 20 patients diagnosed with mpox, 18 (90.0%) had at least a vesicular swab and 1 (5.0%) had only an oropharyngeal swab positive for MPXV. At mpox follow-ups, 2 (10.0%) of 20 patients had first-time positive whole blood samples. Thirteen MPXV-negative samples were positive for mpox-mimicking viruses. Our findings show the excellent performance of the QIAstat-Dx assay for MPXV detection in clinical samples. Further studies are needed before considering a large-scale application of the QIAstat-Dx assay. Full article
(This article belongs to the Special Issue Spreading Monkeypox Virus: Characterization, Epidemiology, and Foreseeable Outcome)
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