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Micromachines
Special Issues
Biomaterials, Biodevices and Tissue Engineering
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Biomaterials, Biodevices and Tissue Engineering

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 11567

Special Issue Editors

Dr. Luis Jesús Villarreal-Gómez

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Guest Editor
Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana 21500, Baja California, Mexico
Interests: tissue engineering; drug delivery systems; biotechnology; nanotechnology; electrospinning; biosensors
Special Issues, Collections and Topics in MDPI journals
Dr. Jose Manuel Cornejo-Bravo

E-Mail Website
Guest Editor
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana 22300, Mexico
Interests: pharmacology; nanomedicine; pharmacy; clinical pharmacology; pharmacovigilance
Special Issues, Collections and Topics in MDPI journals
Dr. Faruk Fonthal Rico

E-Mail Website
Guest Editor
Biomedical Engineering Research Group—GBIO, Universidad Autónoma de Occidente, Cali 760030, Colombia
Interests: optoelectronics; biomaterials; bioengineering; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The innovation in biomaterials in several forms, compositions, and uses has seen exponential growth over the past 10 years and has led to increased confidence in the industry as regards the design and fabrication of biomedical devices that can be used as drug delivery systems, tissue engineering, and bioelectronic devices such as biosensors or organic solar cells. The choice and adequation of the optimal biomaterial for a specific application with a cost-effective manufacturing process have been the objective of even more scientists around the world. Additionally, the construction of nanostructures has led to many advantageous characteristics of these biomaterials stimulating its bioactivity due to the accessibility of many tissues or incrementing the surface area, leading to a higher load of a bioactive component, among others. One example is the use of the electrospinning technique that permits the fabrication of tridimensional fibrous structures that simulate the tissue’s extracellular matrix, which promotes cell proliferation. Accordingly, this Special Issue seeks to showcase research papers, communications, and review articles that focus on novel methodological developments in micro-and nano-scale fabrication, novel synthesis processes, chemical compositions, nanostructures, coatings, or bioactivity and tissue response in areas of application of tissue engineering, drug delivery systems, and biomedical devices.

We look forward to receiving your submissions.

Dr. Luis Jesús Villarreal-Gómez
Dr. Jose Cornejo-Bravo
Dr. Faruk Fonthal Rico
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biodevices
  • tissue engineering
  • drug delivery systems
  • biosensors
  • nanotechnology

Published Papers (6 papers)

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Research

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16 pages, 2630 KiB  
Article
A Neural Network Approach to Reducing the Costs of Parameter-Setting in the Production of Polyethylene Oxide Nanofibers
by Daniel Solis-Rios, Luis Jesús Villarreal-Gómez, Clara Eugenia Goyes, Faruk Fonthal Rico, José Manuel Cornejo-Bravo, María Berenice Fong-Mata, Jorge Mario Calderón Arenas, Harold Alberto Martínez Rincón and David Abdel Mejía-Medina
Micromachines 2023, 14(7), 1410; https://doi.org/10.3390/mi14071410 - 12 Jul 2023
Cited by 1 | Viewed by 1160
Abstract
Nanofibers, which are formed by the electrospinning process, are used in a variety of applications. For this purpose, a specific diameter suited for each application is required, which is achieved by varying a set of parameters. This parameter adjustment process is empirical and [...] Read more.
Nanofibers, which are formed by the electrospinning process, are used in a variety of applications. For this purpose, a specific diameter suited for each application is required, which is achieved by varying a set of parameters. This parameter adjustment process is empirical and works by trial and error, causing high input costs and wasting time and financial resources. In this work, an artificial neural network model is presented to predict the diameter of polyethylene nanofibers, based on the adjustment of 15 parameters. The model was trained from 105 records from data obtained from the literature and was then validated with nine nanofibers that were obtained and measured in the laboratory. The average error between the actual results was 2.29%. This result differs from those taken in an evaluation of the dataset. Therefore, the importance of increasing the dataset and the validation using independent data is highlighted. Full article
(This article belongs to the Special Issue Biomaterials, Biodevices and Tissue Engineering)
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15 pages, 1902 KiB  
Article
5-Fluorouracil-Encapsulated Films Using Exopolysaccharides from a Thermophilic Bacterium Geobacillus sp. WSUCF1 for Topical Drug Delivery
by Joseph M. Laubach and Rajesh K. Sani
Micromachines 2023, 14(5), 1092; https://doi.org/10.3390/mi14051092 - 22 May 2023
Viewed by 1076
Abstract
Bacteria are capable of producing a specific type of biopolymer, termed exopolysaccharides (EPSs). EPSs from thermophile Geobacillus sp. strain WSUCF1 specifically can be assembled using cost-effective lignocellulosic biomass as the primary carbon substrate in lieu of traditional sugars. 5-fluorouracil (5-FU) is an FDA-approved, [...] Read more.
Bacteria are capable of producing a specific type of biopolymer, termed exopolysaccharides (EPSs). EPSs from thermophile Geobacillus sp. strain WSUCF1 specifically can be assembled using cost-effective lignocellulosic biomass as the primary carbon substrate in lieu of traditional sugars. 5-fluorouracil (5-FU) is an FDA-approved, versatile chemotherapeutic that has yielded high efficacy against colon, rectum, and breast cancers. The present study investigates the feasibility of a 5% 5-fluorouracil film using thermophilic exopolysaccharides as the foundation in conjunction with a simple self-forming method. The drug-loaded film formulation was seen to be highly effective against A375 human malignant melanoma at its current concentration with viability of A375 dropping to 12% after six hours of treatment. A drug release profile revealed a slight burst release before it settled into an extended and maintained release of 5-FU. These initial findings provide evidence for the versatility of thermophilic exopolysaccharides produced from lignocellulosic biomass to act as a chemotherapeutic-delivering device and expand the overall applications of extremophilic EPSs. Full article
(This article belongs to the Special Issue Biomaterials, Biodevices and Tissue Engineering)
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13 pages, 3965 KiB  
Article
Influence of Aluminum and Copper on Mechanical Properties of Biocompatible Ti-Mo Alloys: A Simulation-Based Investigation
by Omid Ashkani, Mohammad Reza Tavighi, Mojtaba Karamimoghadam, Mahmoud Moradi, Mahdi Bodaghi and Mohammad Rezayat
Micromachines 2023, 14(5), 1081; https://doi.org/10.3390/mi14051081 - 20 May 2023
Cited by 11 | Viewed by 2039
Abstract
The use of titanium and titanium-based alloys in the human body due to their resistance to corrosion, implant ology and dentistry has led to significant progress in promoting new technologies. Regarding their excellent mechanical, physical and biological performance, new titanium alloys with non-toxic [...] Read more.
The use of titanium and titanium-based alloys in the human body due to their resistance to corrosion, implant ology and dentistry has led to significant progress in promoting new technologies. Regarding their excellent mechanical, physical and biological performance, new titanium alloys with non-toxic elements and long-term performance in the human body are described today. The main compositions of Ti-based alloys and properties comparable to existing classical alloys (C.P. TI, Ti-6Al-4V, Co-Cr-Mo, etc.) are used for medical applications. The addition of non-toxic elements such as Mo, Cu, Si, Zr and Mn also provides benefits, such as reducing the modulus of elasticity, increasing corrosion resistance and improving biocompatibility. In the present study, when choosing Ti-9Mo alloy, aluminum and copper (Cu) elements were added to it. These two alloys were chosen because one element is considered a favorable element for the body (copper) and the other element is harmful to the body (aluminum). By adding the copper alloy element to the Ti-9Mo alloy, the elastic modulus decreases to a minimum value of 97 GPa, and the aluminum alloy element increases the elastic modulus up to 118 GPa. Due to their similar properties, Ti-Mo-Cu alloys are found to be a good optional alloy to use. Full article
(This article belongs to the Special Issue Biomaterials, Biodevices and Tissue Engineering)
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19 pages, 8447 KiB  
Article
Metal-Chelating Self-Assembling Peptide Nanofiber Scaffolds for Modulation of Neuronal Cell Behavior
by Kenana Dayob, Aygul Zengin, Ruslan Garifullin, Mustafa O. Guler, Timur I. Abdullin, Abdulla Yergeshov, Diana V. Salakhieva, Hong Hanh Cong and Mohamed Zoughaib
Micromachines 2023, 14(4), 883; https://doi.org/10.3390/mi14040883 - 19 Apr 2023
Cited by 1 | Viewed by 2025
Abstract
Synthetic peptides are promising structural and functional components of bioactive and tissue-engineering scaffolds. Here, we demonstrate the design of self-assembling nanofiber scaffolds based on peptide amphiphile (PA) molecules containing multi-functional histidine residues with trace metal (TM) coordination ability. The self-assembly of PAs and [...] Read more.
Synthetic peptides are promising structural and functional components of bioactive and tissue-engineering scaffolds. Here, we demonstrate the design of self-assembling nanofiber scaffolds based on peptide amphiphile (PA) molecules containing multi-functional histidine residues with trace metal (TM) coordination ability. The self-assembly of PAs and characteristics of PA nanofiber scaffolds along with their interaction with Zn, Cu, and Mn essential microelements were studied. The effects of TM-activated PA scaffolds on mammalian cell behavior, reactive oxygen species (ROS), and glutathione levels were shown. The study reveals the ability of these scaffolds to modulate adhesion, proliferation, and morphological differentiation of neuronal PC-12 cells, suggesting a particular role of Mn(II) in cell-matrix interaction and neuritogenesis. The results provide a proof-of-concept for the development of histidine-functionalized peptide nanofiber scaffolds activated with ROS- and cell-modulating TMs to induce regenerative responses. Full article
(This article belongs to the Special Issue Biomaterials, Biodevices and Tissue Engineering)
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Review

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28 pages, 3985 KiB  
Review
Lignocellulosic Bionanomaterials for Biosensor Applications
by Ekrem Durmaz, Selva Sertkaya, Hande Yilmaz, Cagri Olgun, Orhan Ozcelik, Ayhan Tozluoglu and Zeki Candan
Micromachines 2023, 14(7), 1450; https://doi.org/10.3390/mi14071450 - 19 Jul 2023
Cited by 3 | Viewed by 1748
Abstract
The rapid population growth, increasing global energy demand, climate change, and excessive use of fossil fuels have adversely affected environmental management and sustainability. Furthermore, the requirements for a safer ecology and environment have necessitated the use of renewable materials, thereby solving the problem [...] Read more.
The rapid population growth, increasing global energy demand, climate change, and excessive use of fossil fuels have adversely affected environmental management and sustainability. Furthermore, the requirements for a safer ecology and environment have necessitated the use of renewable materials, thereby solving the problem of sustainability of resources. In this perspective, lignocellulosic biomass is an attractive natural resource because of its abundance, renewability, recyclability, and low cost. The ever-increasing developments in nanotechnology have opened up new vistas in sensor fabrication such as biosensor design for electronics, communication, automobile, optical products, packaging, textile, biomedical, and tissue engineering. Due to their outstanding properties such as biodegradability, biocompatibility, non-toxicity, improved electrical and thermal conductivity, high physical and mechanical properties, high surface area and catalytic activity, lignocellulosic bionanomaterials including nanocellulose and nanolignin emerge as very promising raw materials to be used in the development of high-impact biosensors. In this article, the use of lignocellulosic bionanomaterials in biosensor applications is reviewed and major challenges and opportunities are identified. Full article
(This article belongs to the Special Issue Biomaterials, Biodevices and Tissue Engineering)
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19 pages, 8640 KiB  
Review
A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications
by Ishita Allu, Ajay Kumar Sahi, Pooja Kumari, Karunya Sakhile, Alina Sionkowska and Shravanya Gundu
Micromachines 2023, 14(4), 865; https://doi.org/10.3390/mi14040865 - 17 Apr 2023
Cited by 10 | Viewed by 2561
Abstract
The process of wound healing is complex and involves the interaction of multiple cells, each with a distinct role in the inflammatory, proliferative, and remodeling phases. Chronic, nonhealing wounds may result from reduced fibroblast proliferation, angiogenesis, and cellular immunity, often associated with diabetes, [...] Read more.
The process of wound healing is complex and involves the interaction of multiple cells, each with a distinct role in the inflammatory, proliferative, and remodeling phases. Chronic, nonhealing wounds may result from reduced fibroblast proliferation, angiogenesis, and cellular immunity, often associated with diabetes, hypertension, vascular deficits, immunological inadequacies, and chronic renal disease. Various strategies and methodologies have been explored to develop nanomaterials for wound-healing treatment. Several nanoparticles such as gold, silver, cerium oxide and zinc possess antibacterial properties, stability, and a high surface area that promotes efficient wound healing. In this review article, we investigate the effectiveness of cerium oxide nanoparticles (CeO2NPs) in wound healing—particularly the effects of reducing inflammation, enhancing hemostasis and proliferation, and scavenging reactive oxygen species. The mechanism enables CeO2NPs to reduce inflammation, modulate the immunological system, and promote angiogenesis and tissue regeneration. In addition, we investigate the efficacy of cerium oxide-based scaffolds in various wound-healing applications for creating a favorable wound-healing environment. Cerium oxide nanoparticles (CeO2NPs) exhibit antioxidant, anti-inflammatory, and regenerative characteristics, enabling them to be ideal wound healing material. Investigations have shown that CeO2NPs can stimulate wound closure, tissue regeneration, and scar reduction. CeO2NPs may also reduce bacterial infections and boost wound-site immunity. However, additional study is needed to determine the safety and efficacy of CeO2NPs in wound healing and their long-term impacts on human health and the environment. The review reveals that CeO2NPs have promising wound-healing properties, but further study is needed to understand their mechanisms of action and ensure their safety and efficacy. Full article
(This article belongs to the Special Issue Biomaterials, Biodevices and Tissue Engineering)
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