Micromachines in Nanomedicine

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1594

Special Issue Editor

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Guest Editor
Medical Systems Central Scientific Facility, Max Planck Institute for Intelligent Systems, 70569 Stuttgart, Germany
Interests: robotics; nanoparticles; contrast agents; non-invasive interventions; radiofrequency (RF) devices; magnetic resonance imaging (MRI)

Special Issue Information

Dear Colleagues,

The robotics approach, where multiple functions could be integrated into a single nanocarrier system, presents disruptive solutions envisioned to overcome the shortcomings of conventional drug delivery, medical devices, and surgical interventions. Nanoparticles have already been proven as non-invasive medical devices for drug delivery and neural stimulation, in surgical interventions for tissue engineering and ablation, in biosensing, and in diagnostic imaging. Additional functionalization of nanoparticles would bring unlimited combinations of multiple functions, making it possible to navigate, track, sense, and release agents at the desired location, achieving better diagnostic and therapeutic efficacy, while preventing unwanted systemic and side effects. The ultimate goal is to make safer, more precise, on demand execution of function and at the same time provide minimally invasive interventions void of human factor. While nanosystems are envisioned to revolutionize medicine, further research is necessary to address many unsolved and unanswered questions related to the design, delivery, functionality, safety, environmental impact, and ultimately efficacy of such systems. We dedicate this issue and cordially invite researchers with original research ideas related to any of these topics to submit their manuscript.

Dr. Jelena Lazovic
Guest Editor

Manuscript Submission Information

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  • nanoparticles
  • nanocarriers
  • biosensors
  • contrast agents
  • biomedical imaging
  • robotics
  • non-invasive interventions
  • labeling
  • tracking
  • toxicity
  • environment

Published Papers (1 paper)

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24 pages, 16614 KiB  
The Second Derivative of Fullerene C60 (SD-C60) and Biomolecular Machinery of Hydrogen Bonds: Water-Based Nanomedicine
by Lidija R. Matija, Ivana Mladen Stankovic, Milica Puric, Milica Miličić, Danijela Maksimović-Ivanić, Sanja Mijatovic, Tamara Krajnović, Vuk Gordic and Djuro Lj. Koruga
Micromachines 2023, 14(12), 2152; https://doi.org/10.3390/mi14122152 - 25 Nov 2023
Cited by 1 | Viewed by 1122
The human body contains 60–70% water, depending on age. As a body fluid, it is not only a medium in which physical and chemical processes take place, but it is also one of the active mediators. Water is the richest substance with non-covalent [...] Read more.
The human body contains 60–70% water, depending on age. As a body fluid, it is not only a medium in which physical and chemical processes take place, but it is also one of the active mediators. Water is the richest substance with non-covalent hydrogen bonds. Water molecules, by themselves (in vacuum), are diamagnetic but when organized into clusters, they become diamagnetic or paramagnetic. Also, biomolecules (DNA, collagen, clathrin, and other proteins) have non-covalent hydrogen bonds in their structure. The interaction, as well as signal transmission, between water and biomolecules is achieved through the vibrations of covalent and non-covalent hydrogen bonds, which determine the state and dynamics of conformational changes in biomolecules. Disruptive conformational changes in biomolecules, cells, and tissues lead to their dysfunctionality, so they are a frequent cause of many disorders and diseases. For example, the rearrangement of hydrogen bonding due to mitochondrial disease mutation in cytochrome bc1 disturbs heme bH redox potential and spin state. In order to prevent and repair the dysfunctional conformational changes, a liquid substance was developed based on the second derivative of the C60 molecule (SD-C60), which has classical and quantum properties. The characterization of SD-C60 by UV-VIS-NIR, FTIR, TEM, and AFM/MFM was performed and it is shown that SD-C60 water layers generate vibrations with near-zero phase dispersion which are transmitted through Fibonacci’s water chains to biomolecules. In comparison with previously published SD-C60 derivate (3HFWC, size until 10 nm, and 1–5 water layers), the improved formulation (3HFWC-W, size 10–25 nm, and 6–9 water layers) showed multiplied cytotoxic activity against melanoma cell lines of different aggressiveness. Apart from this, the mode of action was preserved and based on an induction of senescence rather than cell death. Importantly, high selectivity towards malignant phenotypes was detected. Observed effects can be ascribed to a machinery of hydrogen bonds, which are generated in SD-C60 and transmitted through water to biomolecules. This approach may open a new field in science and healthcare—a “water-based nanomedicine”. Full article
(This article belongs to the Special Issue Micromachines in Nanomedicine)
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