Nanoparticles: The Future of Drug Delivery

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B3: Nanoparticles in Biomedicine".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3205

Special Issue Editors

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310030, China
Interests: biomaterials; targeted drug delivery systems; interventional therapy
Special Issues, Collections and Topics in MDPI journals
Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310009, China
Interests: nanomotors; ferritin-based nanoparticles; nanomaterials for non-apoptotic cell death; nanomaterials for autophagy regulation

Special Issue Information

Dear Colleagues,

The emergence of nanotechnology has paved the way towards the precise treatment of different diseases by exploiting intrinsic physico-chemical properties of nanoparticles. In this Special Issue, Nanotechnology primarily focuses on nanoscale particles with under 200 nm diameter and their delivery systems. Current drug delivery nanosystems includes liposomes, solid nanoparticles, nanoparticles, polymeric micelles, nanogels, and extracellular vesicles. Therapeutic agents can be loaded into the core or onto the surface of nanosystems via chemical conjugation, physical encapsulation, or electrostatic adsorption. This process allows for the extended blood circulation of drugs, enhanced bioavailability, improved therapeutic responses, and reduced side effects. However, the designed nanosystems also face various challenges, including intrinsic toxicity, off-target effects and obstacles for clinical transformation. Accordingly, this Special Issue seeks to showcase research papers and review articles that focus on developments on novel nanosystem developments and their use in various biomedical applications.Moreover, comprehensive studies on the toxicity, degradation and metabolism of existing nanoparticles are also welcome.

Prof. Dr. Yongzhong Du
Prof. Xiaoling Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Dr. Xiaoling Xu
Prof. Dr. Yongzhong Du
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • solid nanoparticles
  • nanoparticles
  • polymeric micelles
  • nanogels
  • extracellular vesicles
  • biomedical applications
  • toxicity
  • degradation
  • metabolism

Published Papers (1 paper)

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Research

16 pages, 5026 KiB  
Article
Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride
by Madiha Melha Yahoum, Selma Toumi, Hichem Tahraoui, Sonia Lefnaoui, Mohammed Kebir, Abdeltif Amrane, Aymen Amin Assadi, Jie Zhang and Lotfi Mouni
Micromachines 2023, 14(3), 609; https://doi.org/10.3390/mi14030609 - 06 Mar 2023
Cited by 5 | Viewed by 2895
Abstract
This work aimed to formulate xanthan gum microspheres for the encapsulation of metformin hydrochloride, according to the process of ionotropic gelation. The obtained microparticles, based on various fractions of xanthan gum (0.5–1.25), were subjected to different physico-chemical tests and a drug release study. [...] Read more.
This work aimed to formulate xanthan gum microspheres for the encapsulation of metformin hydrochloride, according to the process of ionotropic gelation. The obtained microparticles, based on various fractions of xanthan gum (0.5–1.25), were subjected to different physico-chemical tests and a drug release study. Microspheres with an average size varying between 110.96 μm and 208.27 μm were obtained. Encapsulation efficiency reached 93.11% at a 1.25% biopolymer concentration. The swelling study showed a swelling rate reaching 29.8% in the gastric medium (pH 1.2) and 360% in the intestinal medium (pH 6.8). The drug release studies showed complete metformin hydrochloride release from the beads, especially those prepared from xanthan gum at the concentration of 1.25%, in intestinal medium at 90.00% after 6 h. However, limited and insignificant drug release was observed within the gastric medium (32.50%). The dissolution profiles showed sustained release kinetics. Full article
(This article belongs to the Special Issue Nanoparticles: The Future of Drug Delivery)
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