50 Years of Engineered Cell Patterning: From 2D to Dynamic 3D Multi Cultures
A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B2: Biofabrication and Tissue Engineering".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 1493
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tissues are organized structures comprising many cell types in an organized manner to fulfill a specific function. Examples are ubiquitous throughout the human body (e.g., brain structure, blood vessel shape, organization, gut epithelium, mammary duct), and dysregulations in cell organization can lead to severe pathologies, including neurodegenerative disorders and cancer.
Fifty years ago, the first reports of cell patterning were published. They consisted of selective coatings that promoted or inhibited cell adhesion to a 2D surface. These first reports have been instrumental in many studies of cell function and communication. Further, early reports have paved the way for more complex cell patterning protocols. Since then, much progress has been made in cell patterning, including many microfluidic devices dedicated to this end. However, the concept’s importance remains central in bioengineering. More recent reports have focused on cell patterning in 2D and 3D structures that mimic specific cell organizations from the human body (e.g., blood vessels, layered epithelial) and allow the study of specific cellular functions, such as transmigration, angiogenesis, cell-to-cell communication, or changes in proliferation.
This Special Issue will focus on the advances made in different cell patterning approaches (in 2D and 3D) and their biological applications. Two-dimensional cell patterning for monoculture or coculture approaches, the specific organization of cell types using microfluidic devices (e.g., based on liquid pinning mechanisms), and mimicry of 3D cellular structures are welcome in this issue (e.g., use of scaffolds, 3D printing). Given that the technology for cell patterning has been around for a while, we encourage authors to capitalize on recent advances in the field.
Dr. María Virumbrales-Muñoz
Guest Editor
Manuscript Submission Information
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