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Dr. Ali Ahmadi

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School of Sustainable Design Engineering, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI C1A 4P3, Canada
Interests: bioprinting; microfluidics; drop-based systems; electrohydrodynamics

Special Issue Information

Dear Colleagues,

3D bioprinting is defined as the development of complex living and non-living biological constructs from materials including living cells, extracellular matrices, and biomaterials (also known as bioiniks). In the short term, bioprinting technology is essential for developing highly predictive living tissue-based technologies for drug discovery, and complex in vitro models of human diseases. In the long term, bioprinting can potentially contribute to the development of novel biotechnologies for organ transplants, gene therapy, smart drug delivery systems and biomimetic devices. Consequently, the wide range of potential applications of bioprinting strongly suggests that this emerging technology will become a new paradigm for 21st century manufacturing and biotechnology.

This special issue covers all aspects of 3D bioprinting technology with emphasis on the recent advances in the development and optimization of printhead technologies and bioinks. Topics covered include but not limited to printhead technogies, bioinks, pre-bioprinting, post-bioprinting, biofabrication window, emerging applications of 3D bioprinting technology.

Dr. Ali Ahmadi
Guest Editor

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Keywords

3D printing prtintheads
Bioinks
Scaffolds
Pre-bioprinting
Post-bioprinting
Biofabrication window

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18 pages, 4035 KiB

Open AccessArticle

Shape Fidelity of 3D-Bioprinted Biodegradable Patches

by Mikail Temirel, Christopher Hawxhurst and Savas Tasoglu

Micromachines 2021, 12(2), 195; https://doi.org/10.3390/mi12020195 - 13 Feb 2021

Cited by 14 | Viewed by 3334

Abstract

There is high demand in the medical field for rapid fabrication of biodegradable patches at low cost and high throughput for various instant applications, such as wound healing. Bioprinting is a promising technology, which makes it possible to fabricate custom biodegradable patches. However, several challenges with the physical and chemical fidelity of bioprinted patches must be solved to increase the performance of patches. Here, we presented two hybrid hydrogels made of alginate-cellulose nanocrystal (CNC) (2% w/v alginate and 4% w/v CNC) and alginate-TEMPO oxidized cellulose nanofibril (T-CNF) (4% w/v alginate and 1% w/v T-CNC) via ionic crosslinking using calcium chloride (2% w/v). These hydrogels were rheologically characterized, and printing parameters were tuned for improved shape fidelity for use with an extrusion printing head. Young’s modulus of 3D printed patches was found to be 0.2–0.45 MPa, which was between the physiological ranges of human skin. Mechanical fidelity of patches was assessed through cycling loading experiments that emulate human tissue motion. 3D bioprinted patches were exposed to a solution mimicking the body fluid to characterize the biodegradability of patches at body temperature. The biodegradation of alginate-CNC and alginate-CNF was around 90% and 50% at the end of the 30-day in vitro degradation trial, which might be sufficient time for wound healing. Finally, the biocompatibility of the hydrogels was tested by cell viability analysis using NIH/3T3 mouse fibroblast cells. This study may pave the way toward improving the performance of patches and developing new patch material with high physical and chemical fidelity for instant application. Full article

(This article belongs to the Special Issue Bioprinting 2021)

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