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Micromachines
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Micromachines for Dielectrophoresis, 3rd Edition
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Special Issue "Micromachines for Dielectrophoresis, 3rd Edition"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C：Chemistry".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 2315

Special Issue Editor

Dr. Rodrigo Martinez-Duarte

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, USA
Interests: micromanufacturing; biomanufacturing; carbonaceous materials; electrokinetics; microfluidics; bacteria; composites; healthcare diagnostics; multicultural collaboration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dielectrophoresis (DEP) is an effective technique for the label-free identification and manipulation of targeted particles. Its applications are numerous, ranging from clinical diagnostics and therapeutics to advanced manufacturing and micro/nanorobots. Following two successful editions of this Special Issue (https://www.mdpi.com/journal/micromachines/special_issues/Micromachines_for_Dielectrophoresis; https://www.mdpi.com/journal/micromachines/special_issues/Dielectrophoresis_Volume_II), this third installment of "Micromachines for Dielectrophoresis" continues to emphasize novel techniques and processes for the fabrication of the next generation of devices that will further the performance of known applications and widen the range of possible applications of DEP. These innovations include new materials and geometries, volumetric three-dimensional (3D) structures, cost-reducing approaches, large-scale manufacturing, and disposable devices. Submissions that assess the effects of process parameters on the performance of DEP devices are particularly encouraged. Submissions integrating modeling and experimentation are preferred.

Dr. Rodrigo Martinez-Duarte
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfabrication
  • nanofabrication
  • materials
  • 3D printing
  • manufacturing
  • electrokinetics
  • performance

Related Special Issues

Published Papers (3 papers)

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Research

13 pages, 1422 KiB  
Article
High-Frequency Dielectrophoresis Reveals That Distinct Bio-Electric Signatures of Colorectal Cancer Cells Depend on Ploidy and Nuclear Volume
by
Josie L. Duncan
,
Mathew Bloomfield
,
Nathan Swami
,
Daniela Cimini
and
Rafael V. Davalos
Micromachines 2023, 14(9), 1723; https://doi.org/10.3390/mi14091723 - 01 Sep 2023
Viewed by 681
Abstract
Aneuploidy, or an incorrect chromosome number, is ubiquitous among cancers. Whole-genome duplication, resulting in tetraploidy, often occurs during the evolution of aneuploid tumors. Cancers that evolve through a tetraploid intermediate tend to be highly aneuploid and are associated with poor patient prognosis. The [...] Read more.
Aneuploidy, or an incorrect chromosome number, is ubiquitous among cancers. Whole-genome duplication, resulting in tetraploidy, often occurs during the evolution of aneuploid tumors. Cancers that evolve through a tetraploid intermediate tend to be highly aneuploid and are associated with poor patient prognosis. The identification and enrichment of tetraploid cells from mixed populations is necessary to understand the role these cells play in cancer progression. Dielectrophoresis (DEP), a label-free electrokinetic technique, can distinguish cells based on their intracellular properties when stimulated above 10 MHz, but DEP has not been shown to distinguish tetraploid and/or aneuploid cancer cells from mixed tumor cell populations. Here, we used high-frequency DEP to distinguish cell subpopulations that differ in ploidy and nuclear size under flow conditions. We used impedance analysis to quantify the level of voltage decay at high frequencies and its impact on the DEP force acting on the cell. High-frequency DEP distinguished diploid cells from tetraploid clones due to their size and intracellular composition at frequencies above 40 MHz. Our findings demonstrate that high-frequency DEP can be a useful tool for identifying and distinguishing subpopulations with nuclear differences to determine their roles in disease progression. Full article
(This article belongs to the Special Issue Micromachines for Dielectrophoresis, 3rd Edition)
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13 pages, 3276 KiB  
Article
Migration Study of Dielectrophoretically Manipulated Red Blood Cells in Tapered Aluminium Microelectrode Array: A Pilot Study
by
Muhammad Izzuddin Abd Samad
,
Darven Raj Ponnuthurai
,
Syazwani Izrah Badrudin
,
Mohd Anuar Mohd Ali
,
Mohd Azhar Abdul Razak
,
Muhamad Ramdzan Buyong
and
Rhonira Latif
Micromachines 2023, 14(8), 1625; https://doi.org/10.3390/mi14081625 - 17 Aug 2023
Viewed by 458
Abstract
Dielectrophoresis (DEP) is one of the microfluid-based techniques that can manipulate the red blood cells (RBC) for blood plasma separation, which is used in many medical screening/diagnosis applications. The tapered aluminium microelectrode array (TAMA) is fabricated for potential sensitivity enhancement of RBC manipulation [...] Read more.
Dielectrophoresis (DEP) is one of the microfluid-based techniques that can manipulate the red blood cells (RBC) for blood plasma separation, which is used in many medical screening/diagnosis applications. The tapered aluminium microelectrode array (TAMA) is fabricated for potential sensitivity enhancement of RBC manipulation in lateral and vertical directions. In this paper, the migration properties of dielectrophoretically manipulated RBC in TAMA platform are studied at different peak-to-peak voltage (Vpp) and duration supplied onto the microelectrodes. Positive DEP manipulation is conducted at 440 kHz with the RBC of 4.00 ± 0.2 µm average radius attracted to the higher electric field intensity regions, which are the microelectrodes. High percentage of RBC migration occurred at longer manipulation time and high electrode voltage. During DEP manipulation, the RBC are postulated to levitate upwards, experience the electro-orientation mechanism and form the pearl chains before migrating to the electrodes. The presence of external forces other than the dielectrophoretic force may also affect the migration response of RBC. The safe operating limit of 10 Vpp and manipulation duration of ≤50 s prevent RBC rupture while providing high migration percentage. It is crucial to define the safe working region for TAMA devices that manipulate small RBC volume (~10 µL). Full article
(This article belongs to the Special Issue Micromachines for Dielectrophoresis, 3rd Edition)
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25 pages, 10511 KiB  
Article
The System’s Point of View Applied to Dielectrophoresis in Plate Capacitor and Pointed-versus-Pointed Electrode Chambers
by
Jan Gimsa
and
Michal M. Radai
Micromachines 2023, 14(3), 670; https://doi.org/10.3390/mi14030670 - 17 Mar 2023
Cited by 1 | Viewed by 710
Abstract
The DEP force is usually calculated from the object’s point of view using the interaction of the object’s induced dipole moment with the inducing field. Recently, we described the DEP behavior of high- and low-conductive 200-µm 2D spheres in a square 1 × [...] Read more.
The DEP force is usually calculated from the object’s point of view using the interaction of the object’s induced dipole moment with the inducing field. Recently, we described the DEP behavior of high- and low-conductive 200-µm 2D spheres in a square 1 × 1-mm chamber with a plane-versus-pointed electrode configuration from the system’s point of view. Here we extend our previous considerations to the plane-versus-plane and pointed-versus-pointed electrode configurations. The trajectories of the sphere center and the corresponding DEP forces were calculated from the gradient of the system’s overall energy dissipation for given starting points. The dissipation’s dependence on the sphere’s position in the chamber is described by the numerical “conductance field”, which is the DC equivalent of the capacitive charge-work field. While the plane-versus-plane electrode configuration is field-gradient free without an object, the presence of the highly or low-conductive spheres generates structures in the conductance fields, which result in very similar DEP trajectories. For both electrode configurations, the model describes trajectories with multiple endpoints, watersheds, and saddle points, very high attractive and repulsive forces in front of pointed electrodes, and the effect of mirror charges. Because the model accounts for inhomogeneous objectpolarization by inhomogeneous external fields, the approach allows the modeling of the complicated interplay of attractive and repulsive forces near electrode surfaces and chamber edges. Non-reversible DEP forces or asymmetric magnitudes for the highly and low-conductive spheres in large areas of the chamber indicate the presence of higher-order moments, mirror charges, etc. Full article
(This article belongs to the Special Issue Micromachines for Dielectrophoresis, 3rd Edition)
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