Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.4
Journals
Micromachines
Special Issues
Microelectrodes for Biomedical Applications
share announcement

Microelectrodes for Biomedical Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (1 May 2023) | Viewed by 6833

Special Issue Editor

Dr. Alexander R. Harris

E-Mail Website
Guest Editor
Aikenhead Centre for Medical Discovery, Department of Biomedical Engineering, University of Melbourne, Melbourne 3010, Australia
Interests: electrochemistry; electrophysiology; electrode-tissue interface; emergence; bioethics; epilepsy; tissue modelling

Special Issue Information

Dear Colleagues,

I am pleased to announce this Special Issue of Micromachines, which is focussed on microelectrodes for biomedical applications, is now open for submissions.

Bioelectronic medicine is gaining considerable interest owing to its potential to improve our understanding of biological functions and the diagnosis and treatment of intractable disease and trauma.  Electrodes used to interrogate electrically excitable tissue can be used in vitro or in vivo, including in microelectrode arrays (MEAs) for tissue cultures and tissue slices, cochlear implants, bionic eyes, brain–machine interfaces, deep brain stimulators, spinal cord stimulators and other peripheral nerve electrodes.  Despite the significant patient benefits derived from current electrode designs, they are still limited in performance and lifetime.  For instance, MEAs are typically two-dimensional, preventing the interrogation of three-dimensional tissue cultures. Furthermore, the majority of implanted electrodes are much larger, leading to poor resolution and off-target side effects; however, smaller electrodes are at risk of signal loss due to glial cell encapsulation or corrosion during electrical stimulation.  Moreover, the application of microelectrodes to assess tissue models for drug and disease screening is in its infancy, with a scarcity of research on model composition and function and the impact of different disease aetiologies.

This Special Issue aims to report recent advances in the development, analysis and use of microelectrodes to interrogate excitable tissues.  The scope includes, but is not limited to, microelectrodes used in vitro or in vivo, fabrication, novel materials, sensing and stimulating applications, electrode analysis, peripheral and central neural interfaces, neural models and drug and disease screening.

Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Fabrication of new electrodes for interrogating excitable tissues;
  • Novel materials for improving microelectrode function;
  • Analysis and modelling of microelectrode behaviour;
  • Use of microelectrodes in vitro or in vivo to assess tissue function;
  • Application of new neural models on microelectrodes;
  • Use of microelectrodes for disease or drug screening.

I look forward to receiving your contributions.

Dr. Alexander R. Harris
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioelectronics
  • microelectrode
  • microelectrode array
  • electrode analysis
  • electromaterials
  • drug screening
  • disease screening
  • tissue models

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 2073 KiB  
Article
Electrochemistry in a Two- or Three-Electrode Configuration to Understand Monopolar or Bipolar Configurations of Platinum Bionic Implants
by Alexander R. Harris, David B. Grayden and Sam E. John
Micromachines 2023, 14(4), 722; https://doi.org/10.3390/mi14040722 - 24 Mar 2023
Cited by 5 | Viewed by 4330
Abstract
Electrodes are used in vivo for chemical sensing, electrophysiological recording, and stimulation of tissue. The electrode configuration used in vivo is often optimised for a specific anatomy and biological or clinical outcomes, not electrochemical performance. Electrode materials and geometries are constrained by biostability [...] Read more.
Electrodes are used in vivo for chemical sensing, electrophysiological recording, and stimulation of tissue. The electrode configuration used in vivo is often optimised for a specific anatomy and biological or clinical outcomes, not electrochemical performance. Electrode materials and geometries are constrained by biostability and biocompatibility issues and may be required to function clinically for decades. We performed benchtop electrochemistry, with changes in reference electrode, smaller counter-electrode sizes, and three- or two-electrode configurations. We detail the effects different electrode configurations have on typical electroanalytical techniques used on implanted electrodes. Changes in reference electrode required correction by application of an offset potential. In a two-electrode configuration with similar working and reference/counter-electrode sizes, the electrochemical response was dictated by the rate-limiting charge transfer step at either electrode. This could invalidate calibration curves, standard analytical methods, and equations, and prevent use of commercial simulation software. We provide methods for determining if an electrode configuration is affecting the in vivo electrochemical response. We recommend sufficient details be provided in experimental sections on electronics, electrode configuration, and their calibration to justify results and discussion. In conclusion, the experimental limitations of performing in vivo electrochemistry may dictate what types of measurements and analyses are possible, such as obtaining relative rather than absolute measurements. Full article
(This article belongs to the Special Issue Microelectrodes for Biomedical Applications)
►▼ Show Figures

Figure 1

13 pages, 1752 KiB  
Article
Chronic Stability of Local Field Potentials Using Amorphous Silicon Carbide Microelectrode Arrays Implanted in the Rat Motor Cortex
by Eleanor N. Jeakle, Justin R. Abbott, Joshua O. Usoro, Yupeng Wu, Pegah Haghighi, Rahul Radhakrishna, Brandon S. Sturgill, Shido Nakajima, Teresa T. D. Thai, Joseph J. Pancrazio, Stuart F. Cogan and Ana G. Hernandez-Reynoso
Micromachines 2023, 14(3), 680; https://doi.org/10.3390/mi14030680 - 19 Mar 2023
Cited by 4 | Viewed by 1938
Abstract
Implantable microelectrode arrays (MEAs) enable the recording of electrical activity of cortical neurons, allowing the development of brain-machine interfaces. However, MEAs show reduced recording capabilities under chronic conditions, prompting the development of novel MEAs that can improve long-term performance. Conventional planar, silicon-based devices [...] Read more.
Implantable microelectrode arrays (MEAs) enable the recording of electrical activity of cortical neurons, allowing the development of brain-machine interfaces. However, MEAs show reduced recording capabilities under chronic conditions, prompting the development of novel MEAs that can improve long-term performance. Conventional planar, silicon-based devices and ultra-thin amorphous silicon carbide (a-SiC) MEAs were implanted in the motor cortex of female Sprague–Dawley rats, and weekly anesthetized recordings were made for 16 weeks after implantation. The spectral density and bandpower between 1 and 500 Hz of recordings were compared over the implantation period for both device types. Initially, the bandpower of the a-SiC devices and standard MEAs was comparable. However, the standard MEAs showed a consistent decline in both bandpower and power spectral density throughout the 16 weeks post-implantation, whereas the a-SiC MEAs showed substantially more stable performance. These differences in bandpower and spectral density between standard and a-SiC MEAs were statistically significant from week 6 post-implantation until the end of the study at 16 weeks. These results support the use of ultra-thin a-SiC MEAs to develop chronic, reliable brain-machine interfaces. Full article
(This article belongs to the Special Issue Microelectrodes for Biomedical Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop