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Micromachines
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Biohybrid Lung Assist Devices
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Biohybrid Lung Assist Devices

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B4: Point-of-Care Devices".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 4200

Special Issue Editor

Dr. Bettina Wiegmann

E-Mail Website
Guest Editor
Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany
Interests: tissue engineering; regenerative medicine; endothelial cells; extracorporeal membrane oxygenation; artificial lung; intensive care medicine; ex-vivo lung perfusion; ex vivo heart perfusion; ex vivo limb perfusion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

At present, the only available treatment option for patients suffering from end-stage lung diseases is lung transplantation. However, due to the increasing incidence and prevalence of end-stage lung diseases and the scarcity of suitable donor lungs, lung transplantation is only available for highly selected patients. Contemporary extracorporeal membrane oxygenation (ECMO) systems, developed to compensate the insufficient gas exchange of the failing lungs, are not yet durable enough to ensure long-term lung support (e.g., equivalent to left ventricular assist devices in end-stage heart failure). The most frequent causes for their malfunction are associated with disturbed blood coagulation, induced by foreign materials or the non-physiological blood rheology in the devices. As a result, there is a global research focus on the establishment of implantable (bio-)artificial lungs as long-term assist devices, which can be used as reliable “bridges-to-transplantation”, but also as “final destination” therapy.

In recent years, “biohybrid” approaches and strategies have been introduced to increase the biocompatibility, surface hemocompatibility, gas-exchange efficiency and long-term tolerance of contemporary oxygenators by the introduction of biological components, such as cell seeding or surface coatings with biologically active molecules. Accordingly, this Special Issue of Micromachines on “Biohybrid Lung-Assist Devices” seeks to showcase original research papers, short communications and review articles that focus on state-of-the-art and future developments which can help to understand and to exploit the physical and biological processes inside current and novel designed (biohybrid) lung-assist devices. Authors are kindly invited to submit their latest results.

Topics include, but are not limited to, novel gas exchange membrane materials, new surface treatments for improved bio- and hemocompatibility, active and passive coatings promoting hemocompatibility, biohybrid approaches for membrane biofunctionalization, and computational models for the prediction of transfer rates and optimal fluid dynamics. We also welcome the submission of valuable data and insights coming from “organ-on-a-chip” studies. 

We look forward to receiving your outstanding work for this Special Issue. 

Sincerely,
Dr. Bettina Wiegmann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biohybrid lung
  • implantable
  • wearable
  • gas exchange membrane materials (e.g., polymers/co-polymers)
  • gas exchange membrane symmetries and geometries
  • hollow fiber membrane oxygenator
  • microchannel based lung assist devices
  • production techniques and processes
  • biofunctionalization of membranes
  • biofunctionalization of blood contacting surfaces
  • improved bio-/hemocompatibility
  • computational/in silico models
  • lab-on-a-chip

Published Papers (2 papers)

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Research

19 pages, 2417 KiB  
Article
Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models—Introduction of the “RatOx” Oxygenator and Preliminary In Vitro Results
by Lasse J. Strudthoff, Jannis Focke, Felix Hesselmann, Andreas Kaesler, Ana Martins Costa, Peter C. Schlanstein, Thomas Schmitz-Rode, Ulrich Steinseifer, Niklas B. Steuer, Bettina Wiegmann, Jutta Arens and Sebastian V. Jansen
Micromachines 2023, 14(4), 800; https://doi.org/10.3390/mi14040800 - 31 Mar 2023
Cited by 2 | Viewed by 1645
Abstract
The overall survival rate of extracorporeal life support (ECLS) remains at 60%. Research and development has been slow, in part due to the lack of sophisticated experimental models. This publication introduces a dedicated rodent oxygenator (“RatOx”) and presents preliminary in vitro classification tests. [...] Read more.
The overall survival rate of extracorporeal life support (ECLS) remains at 60%. Research and development has been slow, in part due to the lack of sophisticated experimental models. This publication introduces a dedicated rodent oxygenator (“RatOx”) and presents preliminary in vitro classification tests. The RatOx has an adaptable fiber module size for various rodent models. Gas transfer performances over the fiber module for different blood flows and fiber module sizes were tested according to DIN EN ISO 7199. At the maximum possible amount of effective fiber surface area and a blood flow of 100 mL/min, the oxygenator performance was tested to a maximum of 6.27 mL O2/min and 8.2 mL CO2/min, respectively. The priming volume for the largest fiber module is 5.4 mL, while the smallest possible configuration with a single fiber mat layer has a priming volume of 1.1 mL. The novel RatOx ECLS system has been evaluated in vitro and has demonstrated a high degree of compliance with all pre-defined functional criteria for rodent-sized animal models. We intend for the RatOx to become a standard testing platform for scientific studies on ECLS therapy and technology. Full article
(This article belongs to the Special Issue Biohybrid Lung Assist Devices)
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17 pages, 3041 KiB  
Article
Influence of Aerosolization on Endothelial Cells for Efficient Cell Deposition in Biohybrid and Regenerative Applications
by Maria Cheremkhina, Sarah Klein, Aaron Babendreyer, Andreas Ludwig, Thomas Schmitz-Rode, Stefan Jockenhoevel, Christian G. Cornelissen and Anja Lena Thiebes
Micromachines 2023, 14(3), 575; https://doi.org/10.3390/mi14030575 - 28 Feb 2023
Viewed by 1410
Abstract
The endothelialization of gas exchange membranes can increase the hemocompatibility of extracorporeal membrane oxygenators and thus become a long-term lung replacement option. Cell seeding on large or uneven surfaces of oxygenator membranes is challenging, with cell aerosolization being a possible solution. In this [...] Read more.
The endothelialization of gas exchange membranes can increase the hemocompatibility of extracorporeal membrane oxygenators and thus become a long-term lung replacement option. Cell seeding on large or uneven surfaces of oxygenator membranes is challenging, with cell aerosolization being a possible solution. In this study, we evaluated the endothelial cell aerosolization for biohybrid lung application. A Vivostat® system was used for the aerosolization of human umbilical vein endothelial cells with non-sprayed cells serving as a control. The general suitability was evaluated using various flow velocities, substrate distances and cell concentrations. Cells were analyzed for survival, apoptosis and necrosis levels. In addition, aerosolized and non-sprayed cells were cultured either static or under flow conditions in a dynamic microfluidic model. Evaluation included immunocytochemistry and gene expression via quantitative PCR. Cell survival for all tested parameters was higher than 90%. No increase in apoptosis and necrosis levels was seen 24 h after aerosolization. Spraying did not influence the ability of the endothelial cells to form a confluent cell layer and withstand shear stresses in a dynamic microfluidic model. Immunocytochemistry revealed typical expression of CD31 and von Willebrand factor with cobble-stone cell morphology. No change in shear stress-induced factors after aerosolization was reported by quantitative PCR analysis. With this study, we have shown the feasibility of endothelial cell aerosolization with no significant changes in cell behavior. Thus, this technique could be used for efficient the endothelialization of gas exchange membranes in biohybrid lung applications. Full article
(This article belongs to the Special Issue Biohybrid Lung Assist Devices)
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