Advances in Microtechnology for Cell/Tissue Engineering and Biosensing

A topical collection in Micro (ISSN 2673-8023).

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Editor


E-Mail Website
Collection Editor
1. Advanced Photonics and Biosensing Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology, 2-1 Yamadaoka, Suita 565-0871, Osaka, Japan
2. Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Osaka, Japan
Interests: nanobiotechnology; advanced biosensor; bioMEMS; cell based device; biosensors for IoT
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

This Special Issue features research that aims to advance biotechnology by exploiting the properties of micro-scale structures and materials. In the field of biotechnology, exosomes, viruses, cells, and tissues are micro-sized structures, ranging from submicron to submillimeter, composed of functional biomolecules such as proteins, genes, and lipids. These biochemical environments could be effectively controlled by microfluidic device technologies mainly based on semiconductor microfabrication and photofabrication technologies, etc. Micro-scale electrodes, semiconductors, piezoelectric devices, optical devices, etc. can be used for measurement and analyses for these purposes. We welcome the development of microdevices based on new principles and materials, and the proposal of new biosensing and functional analysis methods of cells and tissues using these devices. This also includes advanced bioengineering such as single-cell analysis, cell differentiation, and tissue functional modification. Such research is expected to promote advanced biotechnology, which could lead to novel biosensing and analyses, cell/tissue engineering, biomedical diagnostics, therapeutic applications, drug discovery, etc.

Prof. Dr. Eiichi Tamiya
Collection Editor

Manuscript Submission Information

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Keywords

  • micro-scale device
  • microfluidics
  • biosensing
  • cell engineering
  • single-cell analysis
  • tissue engineering
  • biomedical diagnosis
  • therapeutic application
  • drug screening

Published Papers (2 papers)

2024

Jump to: 2022

11 pages, 3999 KiB  
Article
Janus Particles in Acoustofluidic Setup: The Interplay between Self-Propulsion and Acoustic Trapping
by Lisa Marie Benko, Vyacheslav R. Misko, Larysa Baraban, Denys Makarov, Antonio Maisto and Wim De Malsche
Micro 2024, 4(1), 185-195; https://doi.org/10.3390/micro4010013 - 16 Mar 2024
Viewed by 553
Abstract
Acoustic focusing of particle flow in microfluidics has been shown to be an efficient tool for particle separation for various chemical and biomedical applications. The mechanism behind the method is the selective effect of the acoustic radiation force on distinct particles. In this [...] Read more.
Acoustic focusing of particle flow in microfluidics has been shown to be an efficient tool for particle separation for various chemical and biomedical applications. The mechanism behind the method is the selective effect of the acoustic radiation force on distinct particles. In this way, they can be selectively focused and separated. The technique can also be applied under stationary conditions, i.e., in the absence of fluid flows. In this study, the manipulation of self-propelled particles, such as Janus particles, in an acoustofluidic setup was investigated. In experiments with self-propelled Janus particles and passive beads, we explored the interplay between self-propulsion and the acoustic radiation force. Our results demonstrated unusual and potentially useful effects such as selective trapping, escape, and assisted escape in binary mixtures of active and passive particles. We also analyzed various aspects related to the behavior of Janus particles in acoustic traps in the presence and absence of flows. Full article
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2022

Jump to: 2024

12 pages, 3040 KiB  
Article
Possibility of Biological Observations Using the Speckle Interferometry-Based Super-Resolution Technology
by Yasuhiko Arai
Micro 2022, 2(4), 620-631; https://doi.org/10.3390/micro2040041 - 31 Oct 2022
Viewed by 1136
Abstract
Speckle interferometry techniques based on the phase-detection method have been widely used to observe microstructures beyond the diffraction limit, and the observations of hard solid samples such as microspheres and micro-characters have been previously reported. In this study, the possibility of applying this [...] Read more.
Speckle interferometry techniques based on the phase-detection method have been widely used to observe microstructures beyond the diffraction limit, and the observations of hard solid samples such as microspheres and micro-characters have been previously reported. In this study, the possibility of applying this super-resolution technology to the observation of biological tissues is investigated using plant-cell chromosomes, which are relatively easy to handle and compatible with the diffraction limit. The results reveal that the new super-resolution technique, which is based on speckle interferometry, can be used to observe cellular tissues with complex structures that are subjected to conventional cell-fixation treatments similar to solid samples. However, the shape of the fixed-treated chromosomes is distorted and differs from that of living cells. Furthermore, when observing real living cells using current optics systems, the sample is typically observed vertically. This study indicates that these optics systems must be improved to allow horizontal placements of the samples in the culture medium. Full article
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