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Metabolites
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Metabolic Analysis in Hematology
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Metabolic Analysis in Hematology

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 8660

Special Issue Editor

Dr. Wen-Chi Yang

E-Mail Website
Guest Editor
Division of Hematology and Medical Oncology, Department of Internal Medicine, Pingtung Christian Hospital, Pingtung 900, Taiwan
Interests: hematological disease; cancer biology; molecular biology; stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolism is important in cell and tissue survival. It also plays an important role in hematological disease, for example, iron metabolism in myelodysplasia patients, and mitochondrial DNA alternation in red blood cell diseases. The clinical significance of metabolic changes for disease progression in hematological diseases has remained largely unresolved. In this Special Issue, we welcome all submissions, including original research and review articles, that have a substantial focus on the measurement, analysis, or biological roles of metabolites, metabolic biomarkers, or metabolic pathways, which relate to hematopoiesis or hematological diseases and highlight the latest discoveries and advances in metabolic dysfunction in hematological diseases. Based on understanding the metabolic/biology pathway in hematological diseases, new outcome-prediction markers or potential targets for therapy may be developed.

Topics of interest include, but are not limited to:

  • The identification, structure elucidation, and quantification of endogenous and exogenous metabolites in hematopoietic cells which relate to hematopoiesis or the pathogenesis of hematological diseases;
  • The identification of biomarker and metabolic profiling in hematological diseases;
  • Nutrition catabolism/metabolism in hematological diseases.

Dr. Wen-Chi Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism
  • hematological disease
  • hematopoiesis
  • pathogenesis

Published Papers (3 papers)

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Research

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16 pages, 4528 KiB  
Article
Discovery of Myeloid-Derived Suppressor Cell-Specific Metabolism by Metabolomic and Lipidomic Profiling
by Jisu Kim, Hwanhui Lee, Hyung-Kyoon Choi and Hyeyoung Min
Metabolites 2023, 13(4), 477; https://doi.org/10.3390/metabo13040477 - 27 Mar 2023
Cited by 1 | Viewed by 1470
Abstract
The endogenous factors that control the differentiation of myeloid-derived suppressor cells (MDSCs) are not yet fully understood. The purpose of this study was to find MDSC-specific biomolecules through comprehensive metabolomic and lipidomic profiling of MDSCs from tumor-bearing mice and to discover potential therapeutic [...] Read more.
The endogenous factors that control the differentiation of myeloid-derived suppressor cells (MDSCs) are not yet fully understood. The purpose of this study was to find MDSC-specific biomolecules through comprehensive metabolomic and lipidomic profiling of MDSCs from tumor-bearing mice and to discover potential therapeutic targets for MDSCs. Partial least squares discriminant analysis was performed on the metabolomic and lipidomic profiles. The results showed that inputs for the serine, glycine, and one-carbon pathway and putrescine are increased in bone marrow (BM) MDSC compared to normal BM cells. Splenic MDSC showed an increased phosphatidylcholine to phosphatidylethanolamine ratio and less de novo lipogenesis products, despite increased glucose concentration. Furthermore, tryptophan was found to be at the lowest concentration in splenic MDSC. In particular, it was found that the concentration of glucose in splenic MDSC was significantly increased, while that of glucose 6-phosphate was not changed. Among the proteins involved in glucose metabolism, GLUT1 was overexpressed during MDSC differentiation but decreased through the normal maturation process. In conclusion, high glucose concentration was found to be an MDSC-specific feature, and it was attributed to GLUT1 overexpression. These results will help to develop new therapeutic targets for MDSCs. Full article
(This article belongs to the Special Issue Metabolic Analysis in Hematology)
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Review

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19 pages, 1730 KiB  
Review
The Role of Cholesterol in Chronic Lymphocytic Leukemia Development and Pathogenesis
by Alana M. White, Oliver G. Best, Anya K. Hotinski, Bryone J. Kuss and Lauren A. Thurgood
Metabolites 2023, 13(7), 799; https://doi.org/10.3390/metabo13070799 - 27 Jun 2023
Cited by 1 | Viewed by 2255
Abstract
Cholesterol has many critical functions in cells. It is a key component of membranes and cell-signalling processes, and it functions as a chemical precursor in several biochemical pathways, such as Vitamin D and steroid synthesis. Cholesterol has also been implicated in the development [...] Read more.
Cholesterol has many critical functions in cells. It is a key component of membranes and cell-signalling processes, and it functions as a chemical precursor in several biochemical pathways, such as Vitamin D and steroid synthesis. Cholesterol has also been implicated in the development and progression of various cancers, in which it is thought to promote cell proliferation, migration, and invasion. Chronic lymphocytic leukemia (CLL) is an example of a lipid-avid cancer that relies on lipid metabolism, rather than glycolysis, to fuel cell proliferation. However, data regarding the role of cholesterol in CLL are conflicting. Studies have shown that dyslipidaemia is more common among CLL patients than age-matched healthy controls, and that CLL patients who take cholesterol-lowering drugs, such as statins, appear to have improved survival rates. Therefore, defining the roles of cholesterol in CLL may highlight the importance of monitoring and managing hyperlipidaemia as part of the routine management of patients with CLL. In this review, we discuss the roles of cholesterol in the context of CLL by examining the literature concerning the trafficking, uptake, endogenous synthesis, and intracellular handling of this lipid. Data from clinical trials investigating various classes of cholesterol and lipid-lowering drugs in CLL are also discussed. Full article
(This article belongs to the Special Issue Metabolic Analysis in Hematology)
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20 pages, 1251 KiB  
Review
Red Blood Cell Metabolism In Vivo and In Vitro
by Angelo D’Alessandro, Alkmini T. Anastasiadi, Vassilis L. Tzounakas, Travis Nemkov, Julie A. Reisz, Anastsios G. Kriebardis, James C. Zimring, Steven L. Spitalnik and Michael P. Busch
Metabolites 2023, 13(7), 793; https://doi.org/10.3390/metabo13070793 - 27 Jun 2023
Cited by 15 | Viewed by 3956
Abstract
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in oxygen transport and its delivery to tissues. However, omics technologies recently revealed the unanticipated complexity of the RBC proteome and metabolome, paving the way for [...] Read more.
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in oxygen transport and its delivery to tissues. However, omics technologies recently revealed the unanticipated complexity of the RBC proteome and metabolome, paving the way for a reinterpretation of the mechanisms by which RBC metabolism regulates systems biology beyond oxygen transport. The new data and analytical tools also informed the dissection of the changes that RBCs undergo during refrigerated storage under blood bank conditions, a logistic necessity that makes >100 million units available for life-saving transfusions every year worldwide. In this narrative review, we summarize the last decade of advances in the field of RBC metabolism in vivo and in the blood bank in vitro, a narrative largely influenced by the authors’ own journeys in this field. We hope that this review will stimulate further research in this interesting and medically important area or, at least, serve as a testament to our fascination with this simple, yet complex, cell. Full article
(This article belongs to the Special Issue Metabolic Analysis in Hematology)
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