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Metabolites
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Endocrine and Metabolic Regulation in Insects
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Endocrine and Metabolic Regulation in Insects

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 11249

Special Issue Editors

Dr. Wen Liu

E-Mail Website1 Website2
Guest Editor
1. College of Plant Sciences & Technology, Huazhong Agricultural University, Wuhan 430070, China
2. Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada
Interests: insect endocrinology; diapause; development; signal pathways; gene function
Dr. Suning Liu

E-Mail Website
Guest Editor
School of Life Sciences, South China Normal University, Guangzhou, China
Interests: juvenile hormones; ecdysone; metamorphosis; reproduction

Special Issue Information

Dear Colleagues,

Insects, as the most numerous and diverse organisms on Earth, are highly adaptative to biotic and abiotic environmental factors, such as microbes, viruses, plant metabolites, nutrients, seasonal shifts, etc. The endocrine systems of insects, in response to environmental stimuli, influence numerous biological processes, including growth, development, reproduction and behavior, achieving a physiological resistance to cope with adverse conditions. Complicated metabolic events, including nutritional homeostasis and functional metabolite production, are highly regulated during these processes. In this Special Issue, we aim to collect research that is relevant to insect hormone biosynthesis, hormone-regulated metabolic and nutritional homeostasis, insect metabolomics, the interactions between insects and plant metabolites, and the effects of microbial metabolites on insects. We welcome original research articles as well as in-depth reviews covering these topics.

Dr. Wen Liu
Dr. Suning Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insect
  • hormone
  • metabolism
  • development
  • environmental factors

Published Papers (5 papers)

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Research

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17 pages, 10945 KiB  
Article
Widely Targeted HPLC-MS/MS Metabolomics Analysis Reveals Natural Metabolic Insights in Insects
by Zhaoxin Li, Yunlong Cheng, Jinxin Chen, Weijun Xu, Wentao Ma, Sheng Li and Erxia Du
Metabolites 2023, 13(6), 735; https://doi.org/10.3390/metabo13060735 - 08 Jun 2023
Cited by 1 | Viewed by 1332
Abstract
Insect metabolites play vital roles in regulating the physiology, behavior, and numerous adaptations of insects, which has contributed to them becoming the largest class of Animalia. However, systematic metabolomics within the insects is still unclear. The present study performed a widely targeted metabolomics [...] Read more.
Insect metabolites play vital roles in regulating the physiology, behavior, and numerous adaptations of insects, which has contributed to them becoming the largest class of Animalia. However, systematic metabolomics within the insects is still unclear. The present study performed a widely targeted metabolomics analysis based on the HPLC-MS/MS technology to construct a novel integrated metabolic database presenting comprehensive multimetabolite profiles from nine insect species across three metamorphosis types. A total of 1442 metabolites were identified, including amino acids and their metabolites, organic acids and their derivatives, fatty acids (FAs), glycerophospholipids (GPs), nucleotides and their metabolites, and benzene and its substituted derivatives. Among them, 622 metabolites were used to generate a 0 and 1 matrix based on their presence or absence, and these metabolites were enriched in arachidonic acid metabolism, tyrosine metabolism, phenylalanine metabolism, and insect hormone biosynthesis pathways. Our study revealed that there is a high coincidence between the evolutionary relationships of the species and the hierarchical cluster based on the types of metabolites, while the quantities of the metabolites show a high diversity among species. The metabolome of the nine representative insects provides an important platform for implementing the analysis of insect systemic metabolites and biological events at the metabolic level. Full article
(This article belongs to the Special Issue Endocrine and Metabolic Regulation in Insects)
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18 pages, 13986 KiB  
Article
Metabolomics Provides New Insights into Host Manipulation Strategies by Asobara japonica (Hymenoptera: Braconidae), a Fruit Fly Parasitoid
by Shengmei Liu, Junwei Zhang, Yifeng Sheng, Ting Feng, Wenqi Shi, Yueqi Lu, Xueying Guan, Xuexin Chen, Jianhua Huang and Jiani Chen
Metabolites 2023, 13(3), 336; https://doi.org/10.3390/metabo13030336 - 24 Feb 2023
Cited by 1 | Viewed by 1710
Abstract
Asobara japonica (Hymenoptera: Braconidae) is an endoparasitoid wasp that can successfully parasitize a wide range of host species across the Drosophila genus, including the invasive crop pest Drosophila suzukii. Parasitoids are capable of regulating the host metabolism to produce the nutritional metabolites [...] Read more.
Asobara japonica (Hymenoptera: Braconidae) is an endoparasitoid wasp that can successfully parasitize a wide range of host species across the Drosophila genus, including the invasive crop pest Drosophila suzukii. Parasitoids are capable of regulating the host metabolism to produce the nutritional metabolites for the survival of their offspring. Here, we intend to investigate the metabolic changes in D. melanogaster hosts after parasitization by A. japonica, using the non-targeted LC-MS (liquid chromatography-mass spectrometry) metabolomics analysis. In total, 3043 metabolites were identified, most of which were not affected by A. japonica parasitization. About 205 metabolites were significantly affected in parasitized hosts in comparison to non-parasitized hosts. The changed metabolites were divided into 10 distinct biochemical groups. Among them, most of the lipid metabolic substances were significantly decreased in parasitized hosts. On the contrary, most of metabolites associated with the metabolism of amino acids and sugars showed a higher abundance of parasitized hosts, and were enriched for a wide range of pathways. In addition, eight neuromodulatory-related substances were upregulated in hosts post A. japonica parasitization. Our results reveal that the metabolites are greatly changed in parasitized hosts, which might help uncover the underlying mechanisms of host manipulation that will advance our understanding of host–parasitoid coevolution. Full article
(This article belongs to the Special Issue Endocrine and Metabolic Regulation in Insects)
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17 pages, 3001 KiB  
Article
Metabolite Changes in Orange Dead Leaf Butterfly Kallima inachus during Ontogeny and Diapause
by Ming-Jie Li, Guo-Fang Jiang and Wei Wang
Metabolites 2022, 12(9), 804; https://doi.org/10.3390/metabo12090804 - 27 Aug 2022
Cited by 3 | Viewed by 2199
Abstract
Holometabolism is a form of insect development which includes four life stages: egg, larva, pupa, and imago (or adult). The developmental change of whole body in metabolite levels of holometabolous insects are usually ignored and lack study. Diapause is an alternative life-history strategy [...] Read more.
Holometabolism is a form of insect development which includes four life stages: egg, larva, pupa, and imago (or adult). The developmental change of whole body in metabolite levels of holometabolous insects are usually ignored and lack study. Diapause is an alternative life-history strategy that can occur during the egg, larval, pupal, and adult stages in holometabolous insects. Kallima inachus (Lepidoptera: Nymphalidae) is a holometabolous and adult diapausing butterfly. This study was intended to analyze metabolic changes in K. inachus during ontogeny and diapause through a non-targeted UPLC-MS/MS (ultra-performance liquid chromatograph coupled with tandem mass spectrometry) based metabolomics analysis. A variety of glycerophospholipids (11), amino acid and its derivatives (16), and fatty acyls (nine) are crucial to the stage development of K. inachus. 2-Keto-6-acetamidocaproate, N-phenylacetylglycine, Cinnabarinic acid, 2-(Formylamino) benzoic acid, L-histidine, L-glutamate, and L-glutamine play a potentially important role in transition of successive stages (larva to pupa and pupa to adult). We observed adjustments associated with active metabolism, including an accumulation of glycerophospholipids and carbohydrates and a degradation of lipids, as well as amino acid and its derivatives shifts, suggesting significantly changed in energy utilization and management when entering into adult diapause. Alpha-linolenic acid metabolism and ferroptosis were first found to be associated with diapause in adults through pathway analyses. Our study lays the foundation for a systematic study of the developmental mechanism of holometabolous insects and metabolic basis of adult diapause in butterflies. Full article
(This article belongs to the Special Issue Endocrine and Metabolic Regulation in Insects)
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Review

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19 pages, 1704 KiB  
Review
Biological Characteristics and Energy Metabolism of Migrating Insects
by Xiaokang Li, Yan Zhou and Kongming Wu
Metabolites 2023, 13(3), 439; https://doi.org/10.3390/metabo13030439 - 17 Mar 2023
Cited by 3 | Viewed by 2175
Abstract
Through long-distance migration, insects not only find suitable breeding locations and increase the survival space and opportunities for the population but also facilitate large-scale material, energy, and information flow between regions, which is important in maintaining the stability of agricultural ecosystems and wider [...] Read more.
Through long-distance migration, insects not only find suitable breeding locations and increase the survival space and opportunities for the population but also facilitate large-scale material, energy, and information flow between regions, which is important in maintaining the stability of agricultural ecosystems and wider natural ecosystems. In this study, we summarize the changes in biological characteristics such as morphology, ovarian development, reproduction, and flight capability during the seasonal migration of the insect. In consideration of global research work, the interaction between flight and reproduction, the influence and regulation of the insulin-like and juvenile hormone on the flight and reproductive activities of migrating insects, and the types of energy substances, metabolic processes, and hormone regulation processes during insect flight are elaborated. This systematic review of the latest advances in the studies on insect migration biology and energy metabolism will help readers to better understand the biological behavior and regulation mechanism of the energy metabolism of insect migration. Full article
(This article belongs to the Special Issue Endocrine and Metabolic Regulation in Insects)
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19 pages, 784 KiB  
Review
Noncoding RNA Regulation of Hormonal and Metabolic Systems in the Fruit Fly Drosophila
by Ki-Kei Chan, Ting-Fung Chan, William Bendena and Jerome H. L. Hui
Metabolites 2023, 13(2), 152; https://doi.org/10.3390/metabo13020152 - 19 Jan 2023
Cited by 1 | Viewed by 2384
Abstract
The importance of RNAs is commonly recognised thanks to protein-coding RNAs, whereas non-coding RNAs (ncRNAs) were conventionally regarded as ‘junk’. In the last decade, ncRNAs’ significance and roles are becoming noticeable in various biological activities, including those in hormonal and metabolic regulation. Among [...] Read more.
The importance of RNAs is commonly recognised thanks to protein-coding RNAs, whereas non-coding RNAs (ncRNAs) were conventionally regarded as ‘junk’. In the last decade, ncRNAs’ significance and roles are becoming noticeable in various biological activities, including those in hormonal and metabolic regulation. Among the ncRNAs: microRNA (miRNA) is a small RNA transcript with ~20 nucleotides in length; long non-coding RNA (lncRNA) is an RNA transcript with >200 nucleotides; and circular RNA (circRNA) is derived from back-splicing of pre-mRNA. These ncRNAs can regulate gene expression levels at epigenetic, transcriptional, and post-transcriptional levels through various mechanisms in insects. A better understanding of these crucial regulators is essential to both basic and applied entomology. In this review, we intend to summarise and discuss the current understanding and knowledge of miRNA, lncRNA, and circRNA in the best-studied insect model, the fruit fly Drosophila. Full article
(This article belongs to the Special Issue Endocrine and Metabolic Regulation in Insects)
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