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Metabolites
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Antioxidant Effect of Natural Active Substance and Its Effect on...
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Antioxidant Effect of Natural Active Substance and Its Effect on Mammalian Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 10635

Special Issue Editors

Dr. Ahmed M. Sayed

E-Mail Website
Guest Editor
Pharmacognosy Department, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt
Interests: natural product chemistry; medicinal and pharmaceutical chemistry; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Usama Ramadan Abdelmohsen

E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia City 61519, Minia, Egypt
Interests: natural products; metabolomics; marine microbiology; endophytes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) are electron-rich derivatives of atmospheric oxygen(s) and versatile signaling molecules with a wide range of capabilities; if they are not balanced by antioxidant machinery, they can push cells or organisms into oxidative stress. As a result, there is a tightly regulated equilibrium between ROS generation and antioxidant defenses.

Mitochondria are an important part of this balance and the cell's main source of reactive oxygen species (ROS). Evidence of a direct link between mitochondrial oxidative state and several pathological conditions have been identified, e.g., Parkinson syndrome, Alzheimer's disease, and optic atrophies.

A large group of antioxidant chemicals with radical-scavenging properties can be found in natural products. Polyphenols, terpenoids, and essential oil constituents are just a few of the substances that can help prevent oxidative damage. In vivo, they alleviate oxidative stress by quenching radical species, peroxides, and promoters of oxidative processes, as well as acting on redox-sensitive transcription factors.

In this Special Issue, we will focus on the diverse aspects of the triad that links oxidative stress, mitochondria, and oxidative-stress-linked disorders. Additionally, we will shed light on the potential roles of natural products as efficient antioxidant agents. We will gather articles spanning from computer-based molecular modeling to integrated in vitro/in vivo models ranging from molecular to behavioral levels in order to assess the most recent research in this subject.

Dr. Ahmed M. Sayed
Prof. Dr. Usama Ramadan Abdelmohsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • mitochondria
  • molecular modeling
  • in silico antioxidant study
  • polyphenols
  • waste products
  • essential oils

Published Papers (4 papers)

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20 pages, 10549 KiB  
Article
The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study
by Alaa A. Bagalagel, Seham S. El-hawary, Rania Alaaeldin, Abeer H. Elmaidomy, Faisal H. Altemani, Dania S. Waggas, Naseh A. Algehainy, Nizar H. Saeedi, Faisal Alsenani, Fatma A. Mokhtar, Mahmoud A. Elrehany, Mohammad M. Al-Sanea and Usama Ramadan Abdelmohsen
Metabolites 2022, 12(12), 1178; https://doi.org/10.3390/metabo12121178 - 25 Nov 2022
Cited by 9 | Viewed by 1922
Abstract
LC-HRESIMS metabolomic profiling of Olea europaea L. cv. Picual (OEP) (Saudi Arabian olive cultivar, F. Oleacea) revealed 18 compounds. Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer’s disease, it was possible to identify the VEGFA, [...] Read more.
LC-HRESIMS metabolomic profiling of Olea europaea L. cv. Picual (OEP) (Saudi Arabian olive cultivar, F. Oleacea) revealed 18 compounds. Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer’s disease, it was possible to identify the VEGFA, AChE, and DRD2 genes as the top correlated genes to Alzheimer’s disease with 8, 8, and 6 interactions in the same order. The mechanism of action on cellular components, biological processes, and molecular functions was determined by gene enrichment analysis. A biological pathway comparison revealed 13 shared pathways between the identified genes and Alzheimer protein genes (beta-amyloid band tau proteins). The suggested extract’s anti-Alzheimer potential in silico screening was confirmed through in vivo investigation in regressing the neurodegenerative features of Alzheimer’s dementia in an aluminum-intoxicated rat model (protective and therapeutic effects, 100 mg/kg b.w.). In vivo results suggested that OEP extract significantly improved Alzheimer’s rats, which was indicated by the crude extract’s ability to improve T-maze performance; lower elevated serum levels of AChE, AB peptide, and Ph/T ratio; and normalize the reduced level of TAC during the study. The results presented in this study may provide potential dietary supplements for the management of Alzheimer’s disease. Full article
(This article belongs to the Special Issue Antioxidant Effect of Natural Active Substance and Its Effect on Mammalian Metabolism)
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18 pages, 3810 KiB  
Article
Protective Effect of Catharanthus roseus Extract on Cadmium-Induced Toxicity in Albino Rats: A Putative Mechanism of Detoxification
by Mohammad Hashim, Hussain Arif, Baby Tabassum, Amin Arif, Ahmed A. Rehman, Shahnawaz Rehman, Rehnuma Khanam, Bushra Khan, Arif Hussain, Jameel Barnawi, Faris J. Tayeb, Naseh Algehainy, Faisal H. Altemani, Rashid Mir, Fahad M. Almutairi, Mohammad Fahad Ullah, Imadeldin Elfaki and Mohammad Rehan Ajmal
Metabolites 2022, 12(11), 1059; https://doi.org/10.3390/metabo12111059 - 02 Nov 2022
Cited by 3 | Viewed by 3284
Abstract
Globally, people are highly affected by Cadmium (Cd), the most hazardous heavy metal. It has been implicated in various pathogeneses. Oxidative stress may be one the main reasons for Cd-induced disorders in the body. This article investigates the protective ability of Catharanthus roseus [...] Read more.
Globally, people are highly affected by Cadmium (Cd), the most hazardous heavy metal. It has been implicated in various pathogeneses. Oxidative stress may be one the main reasons for Cd-induced disorders in the body. This article investigates the protective ability of Catharanthus roseus (CR) extract on oxidative stress in the kidney and liver of rats exposed to Cd. After 21 days, a significant increase in MDA concentration (6.81 ± 0.05), (6.64 ± 0.03) was observed in Cd-treated groups compared to the control (5.54 ± 0.02), (5.39 ± 0.04) for the kidney and liver, respectively, while significant changes were observed in the haematological parameters. Antioxidant enzymes, GPx, CAT, and SOD showed a significant decrease in their activity. We established that increasing the concentration of Cd in the presence of H2O2 was able to cause stand scission in pBR322 plasmid DNA, which may be due to the mediation of ROS generated in the process. The antioxidant ability of CR extract was tested in DPPH and H2O2 scavenging assay, depicted by the increase in the percentage inhibition. Upon treatment of CR extract to rats, MDA concentration was decreased for the kidney and liver compared to the Cd-treated groups. This was again confirmed by comet assay of both tissues, where the degree of cellular DNA breakage caused by Cd toxicity decreased significantly upon treatment with CR extract. Overall, the results suggest that Cd plays a major role as an effector metal ion, causing a decrease in the concentration and activity of AO enzymes and enhanced lipid peroxidation. ROS production resulted in oxidative DNA damage within the cell, whereas CR extract showed potential antioxidant activity against ROS-mediated DNA damage induced by Cd poisoning. Full article
(This article belongs to the Special Issue Antioxidant Effect of Natural Active Substance and Its Effect on Mammalian Metabolism)
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21 pages, 6493 KiB  
Article
The Wound-Healing Potential of Olea europaea L. Cv. Arbequina Leaves Extract: An Integrated In Vitro, In Silico, and In Vivo Investigation
by Tarfah Al-Warhi, Abeer H. Elmaidomy, Sherif A. Maher, Dalia H. Abu-Baih, Samy Selim, Mha Albqmi, Mohammad M. Al-Sanea, Taghreed S. Alnusaire, Mohammed M. Ghoneim, Ehab M. Mostafa, Shaimaa Hussein, Ashraf K. El-Damasy, Entesar Ali Saber, Mahmoud A. Elrehany, Ahmed M. Sayed, Eman M. Othman, Mohamed El-Sherbiny and Usama Ramadan Abdelmohsen
Metabolites 2022, 12(9), 791; https://doi.org/10.3390/metabo12090791 - 25 Aug 2022
Cited by 12 | Viewed by 2317
Abstract
Olea europaea L. Cv. Arbequina (OEA) (Oleaceae) is an olive variety species that has received little attention. Besides our previous work for the chemical profiling of OEA leaves using LC–HRESIMS, an additional 23 compounds are identified. An excision wound model is used to [...] Read more.
Olea europaea L. Cv. Arbequina (OEA) (Oleaceae) is an olive variety species that has received little attention. Besides our previous work for the chemical profiling of OEA leaves using LC–HRESIMS, an additional 23 compounds are identified. An excision wound model is used to measure wound healing action. Wounds are provided with OEA (2% w/v) or MEBO® cream (marketed treatment). The wound closure rate related to vehicle-treated wounds is significantly increased by OEA. Comparing to vehicle wound tissues, significant levels of TGF-β in OEA and MEBO® (p < 0.05) are displayed by gene expression patterns, with the most significant levels in OEA-treated wounds. Proinflammatory TNF-α and IL-1β levels are substantially reduced in OEA-treated wounds. The capability of several lignan-related compounds to interact with MMP-1 is revealed by extensive in silico investigation of the major OEA compounds (i.e., inverse docking, molecular dynamics simulation, and ΔG calculation), and their role in the wound-healing process is also characterized. The potential of OEA as a potent MMP-1 inhibitor is shown in subsequent in vitro testing (IC50 = 88.0 ± 0.1 nM). In conclusion, OEA is introduced as an interesting therapeutic candidate that can effectively manage wound healing because of its anti-inflammatory and antioxidant properties. Full article
(This article belongs to the Special Issue Antioxidant Effect of Natural Active Substance and Its Effect on Mammalian Metabolism)
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24 pages, 29234 KiB  
Protocol
Blackberry-Loaded AgNPs Attenuate Hepatic Ischemia/Reperfusion Injury via PI3K/Akt/mTOR Pathway
by Ahmed M. Fathi, Shaimaa Waz, Eman Alaaeldin, Nisreen D. M. Toni, Azza A. K. El-Sheikh, Ahmed M. Sayed, Usama Ramadan Abdelmohsen and Maiiada H. Nazmy
Metabolites 2023, 13(3), 419; https://doi.org/10.3390/metabo13030419 - 13 Mar 2023
Cited by 3 | Viewed by 1718
Abstract
Liver ischemia-reperfusion injury (IRI) is a pathophysiological insult that often occurs during liver surgery. Blackberry leaves are known for their anti-inflammatory and antioxidant activities. Aims: To achieve site-specific delivery of blackberry leaves extract (BBE) loaded AgNPs to the hepatocyte in IRI [...] Read more.
Liver ischemia-reperfusion injury (IRI) is a pathophysiological insult that often occurs during liver surgery. Blackberry leaves are known for their anti-inflammatory and antioxidant activities. Aims: To achieve site-specific delivery of blackberry leaves extract (BBE) loaded AgNPs to the hepatocyte in IRI and to verify possible molecular mechanisms. Methods: IRI was induced in male Wister rats. Liver injury, hepatic histology, oxidative stress markers, hepatic expression of apoptosis-related proteins were evaluated. Non-targeted metabolomics for chemical characterization of blackberry leaves extract was performed. Key findings: Pre-treatment with BBE protected against the deterioration caused by I/R, depicted by a significant improvement of liver functions and structure, as well as reduction of oxidative stress with a concomitant increase in antioxidants. Additionally, BBE promoted phosphorylation of antiapoptotic proteins; PI3K, Akt and mTOR, while apoptotic proteins; Bax, Casp-9 and cleaved Casp-3 expressions were decreased. LC-HRMS-based metabolomics identified a range of metabolites, mainly flavonoids and anthocyanins. Upon comprehensive virtual screening and molecular dynamics simulation, the major annotated anthocyanins, cyanidin and pelargonidin glucosides, were suggested to act as PLA2 inhibitors. Significance: BBE can ameliorate hepatic IRI augmented by BBE-AgNPs nano-formulation via suppressing, oxidative stress and apoptosis as well as stimulation of PI3K/Akt/mTOR signaling pathway. Full article
(This article belongs to the Special Issue Antioxidant Effect of Natural Active Substance and Its Effect on Mammalian Metabolism)
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