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Metabolites
Special Issues
Reviews and Advances in Metabolites and Disease Risk
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Reviews and Advances in Metabolites and Disease Risk

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Thematic Reviews".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5629

Special Issue Editor

Dr. Wei Jie Seow

E-Mail Website
Guest Editor
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore
Interests: molecular biomarkers of environmental exposures and diseases; environmental and cancer epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are calling for the submission of general reviews including systematic reviews and meta-analyses on any topic related to metabolites and disease risk. In recent years, there has been a massive expansion of research output related to metabolomics. Therefore, there is an urgent need to synthesize and summarize the findings to take stock of what we know so far. Systematic reviews provide a summary of published findings and meta-analyses present a statistical analysis of the results of independent studies. They involve a set of methods to systematically search for and synthesize evidence from published studies. They are useful for reconciling inconsistencies across studies, allowing the integration and synthesis of existing knowledge, highlighting research gaps, and guiding subsequent research. We welcome general reviews, systematic reviews and meta-analyses on topics within the domain of metabolite studies, as well as in related fields, which may include but are not limited to the following areas:

  • Diseases;
  • Microbiome;
  • Environmental/lifestyle factors;
  • Metabolomics.

Dr. Wei Jie Seow
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Review

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24 pages, 1669 KiB  
Review
Microbial Tryptophan Metabolism Tunes Host Immunity, Metabolism, and Extraintestinal Disorders
by Moyan Liu, Max Nieuwdorp, Willem M. de Vos and Elena Rampanelli
Metabolites 2022, 12(9), 834; https://doi.org/10.3390/metabo12090834 - 03 Sep 2022
Cited by 14 | Viewed by 3803
Abstract
The trillions of commensal microorganisms comprising the gut microbiota have received growing attention owing to their impact on host physiology. Recent advances in our understandings of the host–microbiota crosstalk support a pivotal role of microbiota-derived metabolites in various physiological processes, as they serve [...] Read more.
The trillions of commensal microorganisms comprising the gut microbiota have received growing attention owing to their impact on host physiology. Recent advances in our understandings of the host–microbiota crosstalk support a pivotal role of microbiota-derived metabolites in various physiological processes, as they serve as messengers in the complex dialogue between commensals and host immune and endocrine cells. In this review, we highlight the importance of tryptophan-derived metabolites in host physiology, and summarize the recent findings on the role of tryptophan catabolites in preserving intestinal homeostasis and fine-tuning immune and metabolic responses. Furthermore, we discuss the latest evidence on the effects of microbial tryptophan catabolites, describe their mechanisms of action, and discuss how perturbations of microbial tryptophan metabolism may affect the course of intestinal and extraintestinal disorders, including inflammatory bowel diseases, metabolic disorders, chronic kidney diseases, and cardiovascular diseases. Full article
(This article belongs to the Special Issue Reviews and Advances in Metabolites and Disease Risk)
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17 pages, 3072 KiB  
Systematic Review
Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review
by Susanth Alapati, Giulio Fortuna, Gordon Ramage and Christopher Delaney
Metabolites 2023, 13(8), 890; https://doi.org/10.3390/metabo13080890 - 27 Jul 2023
Cited by 1 | Viewed by 1403
Abstract
In recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and evaluate metabolite biomarkers and their pathways [...] Read more.
In recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and evaluate metabolite biomarkers and their pathways for OSCC that featured consistently across studies despite methodological variations. Six electronic databases (Medline, Cochrane, Web of Science, CINAHL, ProQuest, and Embase) were reviewed for the longitudinal studies involving OSCC patients and metabolic marker analysis (in accordance with PRISMA 2020). The studies included ranged from the inception of metabolomics in OSCC (i.e., 1 January 2007) to 30 April 2023. The included studies were then assessed for their quality using the modified version of NIH quality assessment tool and QUADOMICS. Thirteen studies were included after screening 2285 studies. The majority of the studies were from South Asian regions, and metabolites were most frequently derived from saliva. Amino acids accounted for more than quarter of the detected metabolites, with glutamate and methionine being the most prominent. The top dysregulated metabolites indicated dysregulation of six significantly enriched pathways including aminoacyl-tRNA biosynthesis, glutathione metabolism and arginine biosynthesis with the false discovery rate (FDR) <0.05. Finally, this review highlights the potential of metabolomics for early diagnosis and therapeutic targeting of OSCC. However, larger studies and standardized protocols are needed to validate these findings and make them a clinical reality. Full article
(This article belongs to the Special Issue Reviews and Advances in Metabolites and Disease Risk)
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