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Metabolites
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Plant Protection Meets Metabolomics
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Plant Protection Meets Metabolomics

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 8553

Special Issue Editor

Dr. Konstantinos A. Aliferis

E-Mail Website
Guest Editor
1. Department of Crop Science, Agricultural University of Athens, Athens, Greece
2. Department of Plant Science, Macdonald Campus, McGill University, Ste-Anne-de-Bellevue, QC, Canada
Interests: nanopesticides; natural product discovery; pesticide ecotoxicology; pesticide metabolomics; pesticide toxicology; pest and pathogen resistance to pesticides; plant metabolomics; plant-microbe interactions

Special Issue Information

Dear Colleagues,

Plant protection products (PPPs) represent the backbone of the agricultural sector. Nonetheless, the great challenges that the agrochemical industry is facing, such as the growing pressure from the public towards reduction in the use of conventional PPPs, the development of resistant populations of pests and pathogens to PPPs, the toxicity of PPPs to non-target organisms, and the presence of residues in the food and the environment, dictate the need for the discovery of improved PPPs. The latter is a prerequisite in order to secure food supply and sustainability. In this context, the implementation of advanced bioanalytical tools is highly foreseen to play a cornerstone role in the effort to achieve such goal. Metabolomics is a bioanalytical tool of high potential for applications in PPPs’ research and development. Such potential has been recently highlighted in the research on, among others, the discovery of new sources of bioactivity, the assessment of the toxicity of PPPs, the discovery of the mode(s)-of-action of bioactive compounds, the study of pathogen, weed, and pest resistance to PPPs, and the mining of the underlying mechanisms during interactions of plants with novel abiotic (bioelicitors) and biotic (plant pathogens, endophytes) agents.

Based on the aforementioned, the Special Issue “Plant Protection Meets Metabolomics” aims to highlight the use and potential of metabolomics in PPPs’ research and development. Both original research and review articles will be considered.

Dr. Konstantinos A. Aliferis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioelicitors
  • cell metabolomics
  • ecotoxicogenomics
  • microbial metabolomics
  • natural product discovery
  • nanopesticides
  • pesticides
  • pesticide metabolomics
  • plant metabolomics
  • plant stress and pesticides
  • toxicogenomics

Published Papers (4 papers)

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Research

19 pages, 5243 KiB  
Article
GC/EI/MS and 1H NMR Metabolomics Reveal the Effect of an Olive Tree Endophytic Bacillus sp. Lipopeptide Extract on the Metabolism of Colletotrichum acutatum
by Evgenia-Anna Papadopoulou, Apostolis Angelis, Alexios-Leandros Skaltsounis and Konstantinos A. Aliferis
Metabolites 2023, 13(4), 462; https://doi.org/10.3390/metabo13040462 - 23 Mar 2023
Cited by 1 | Viewed by 1255
Abstract
The transition to the Green Deal era requires the discovery of alternative sources of bioactivity and an in-depth understanding of their toxicity to target and non-target organisms. Endophytes have recently emerged as a source of bioactivity of high potential for applications in plant [...] Read more.
The transition to the Green Deal era requires the discovery of alternative sources of bioactivity and an in-depth understanding of their toxicity to target and non-target organisms. Endophytes have recently emerged as a source of bioactivity of high potential for applications in plant protection, used either per se as biological control agents or their metabolites as bioactive compounds. The olive tree endophytic isolate Bacillus sp. PTA13 produces an array of bioactive lipopeptides (LPs), which additionally exhibit reduced phytotoxicity, features that make them candidates for further research focusing on olive tree plant protection. Here, GC/EI/MS and 1H NMR metabolomics were employed to study the toxicity of a Bacillus sp. PTA13 LP extract on the olive tree pathogen Colletotrichum acutatum, which causes the devastating disease olive anthracnose. The discovery of resistant isolates of the pathogen to the applied fungicides makes the research on the development of improved sources of bioactivity of paramount importance. Analyses revealed that the applied extract affects the metabolism of the fungus by interfering with the biosynthesis of various metabolites and its energy production. LPs had a great impact on the aromatic amino acid metabolism, the energy equilibrium of the fungus and its fatty acid content. Additionally, the applied LPs affected the levels of pathogenesis-related metabolites, a finding that supports their potential for further research as plant protection agents. Full article
(This article belongs to the Special Issue Plant Protection Meets Metabolomics)
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17 pages, 4943 KiB  
Article
Metabolomic and Genomic Approach to Study Defense Induction by Nesidiocoris tenuis against Tuta absoluta and Tetranychus urticae in Tomato Plants
by Nomi Sarmah, Athanasios Kaldis, Ioannis Kalampokis, Konstantinos A. Aliferis, Andreas Voloudakis and Dionysios Perdikis
Metabolites 2022, 12(9), 838; https://doi.org/10.3390/metabo12090838 - 04 Sep 2022
Cited by 2 | Viewed by 1896
Abstract
The phytophagy of the predator Nesidiocoris tenuis (Hemiptera: Miridae) can trigger defense responses in tomato plants against pests, such as two spotted spider mite Tetranychus urticae (Acari: Tetranychidae) and South American leaf miner Tuta absoluta (Lepidoptera: Gelechiidae). The expression of genes governing Jasmonic [...] Read more.
The phytophagy of the predator Nesidiocoris tenuis (Hemiptera: Miridae) can trigger defense responses in tomato plants against pests, such as two spotted spider mite Tetranychus urticae (Acari: Tetranychidae) and South American leaf miner Tuta absoluta (Lepidoptera: Gelechiidae). The expression of genes governing Jasmonic Acid (JA) biosynthesis pathway and fluctuations in the levels of underlying metabolites have been rarely studied in mirid-infested plants. In the present study, fifteen 3rd instar nymphs of N.tenuis were caged on each top and lower leaf of tomato plants for 4 d to induce plant defense; after this period the predators were removed. With regard to T. absoluta, oviposition preference; larval period; and pupal weight were significantly reduced in N. tenuis-punctured plants. T. urticae adults exhibited a significantly higher escape tendency and reduced survival on punctured plants. Metabolomics confirmed such observations revealing substantial differences between N. tenuis-punctured and unpunctured (control) plants. Metabolites directly associated with the activation of the JA defense pathway, such as the precursor α-linolenic acid, had increased concentrations. The expression of the defense-related genes PI-II, MYC2, VSP2, and HEL was increased in the top leaves and only VSP2 and MBP2 in the lower leaves; interestingly, in the middle (unpunctured) leaves VSP2, HEL, and MBP2 were also upregulated, indicating systemic signaling. Collectively, phytophagy of N. tenuis caused adverse effects on T. absoluta and T. urticae, whereas the multi-omics approach (phenomics, metabolomics, and genomics) offered valuable insights into the nature of the plant defense responses and provided useful evidence for future applications in integrated pest management, plausibly resulting in the reduction in the required pesticide volumes. Full article
(This article belongs to the Special Issue Plant Protection Meets Metabolomics)
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19 pages, 1976 KiB  
Article
New Approaches to Manage Asian Soybean Rust (Phakopsora pachyrhizi) Using Trichoderma spp. or Their Antifungal Secondary Metabolites
by Abbas El-Hasan, Frank Walker, Iris Klaiber, Jochen Schöne, Jens Pfannstiel and Ralf T. Voegele
Metabolites 2022, 12(6), 507; https://doi.org/10.3390/metabo12060507 - 01 Jun 2022
Cited by 5 | Viewed by 2099
Abstract
Attempts have been made to determine the in vitro and in planta suppressive potential of particular Trichoderma strains (T16 and T23) and their secondary metabolites (SMs) against Asian soybean rust (ASR) incited by Phakopsora pachyrhizi. Aside from the previously identified SMs 6-pentyl-α-pyrone [...] Read more.
Attempts have been made to determine the in vitro and in planta suppressive potential of particular Trichoderma strains (T16 and T23) and their secondary metabolites (SMs) against Asian soybean rust (ASR) incited by Phakopsora pachyrhizi. Aside from the previously identified SMs 6-pentyl-α-pyrone (6PAP) and viridiofungin A (VFA), the chemical structures of harzianic acid (HA), iso-harzianic acid (iso-HA), and harzianolide (HZL) were characterized in this study. Our results indicate that exposure of urediospores to 200 ppm 6PAP completely inhibits germination. A slightly higher dosage (250 ppm) of HZL and VFA reduces germination by 53.7% and 44%, respectively. Germ tube elongation seems more sensitive to 6PAP than urediospore germination. On detached leaves, application of conidia of T16 and T23 results in 81.4% and 74.3% protection, respectively. Likewise, 200 ppm 6PAP recorded the highest ASR suppression (98%), followed by HZL (78%) and HA (69%). Treatment of undetached leaves with 6PAP, HA, or HZL reduces ASR severity by 84.2%, 65.8%, and 50.4%, respectively. Disease reduction on the next, untreated trifoliate by T23 (53%), T16 (41%), HZL (42%), and 6PAP (32%) suggests a translocation or systemic activity of the SMs and their producers. To our knowledge, this study provides the first proof for controlling ASR using antifungal SMs of Trichoderma. Our findings strongly recommend the integration of these innovative metabolites, particularly 6PAP and/or their producers in ASR management strategies. Full article
(This article belongs to the Special Issue Plant Protection Meets Metabolomics)
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17 pages, 3795 KiB  
Article
Impacts of Constitutive and Induced Benzoxazinoids Levels on Wheat Resistance to the Grain Aphid (Sitobion avenae)
by Zhanfeng Zhang, Hao Lan, Hehe Cao, Xiangshun Hu, Yongliang Fan, Yue Song, Lijuan Wu and Tong-Xian Liu
Metabolites 2021, 11(11), 783; https://doi.org/10.3390/metabo11110783 - 16 Nov 2021
Cited by 9 | Viewed by 2322
Abstract
Benzoxazinoids are important secondary metabolites in gramineae plants and have inhibitory and toxic effects against a wide range of herbivore pests. However, the relationship between benzoxazinoid level and plant resistance to aphids remains controversial. In this study, we investigated the relationship between benzoxazinoids [...] Read more.
Benzoxazinoids are important secondary metabolites in gramineae plants and have inhibitory and toxic effects against a wide range of herbivore pests. However, the relationship between benzoxazinoid level and plant resistance to aphids remains controversial. In this study, we investigated the relationship between benzoxazinoids composition and concentration in wheat leaves and the resistance to the grain aphid Sitobion avenae. Overall, six benzoxazinoids were detected and identified by mass spectrometry based metabolites profiling, including three lactams, two hydroxamic acids, and one methyl derivative. The constitutive levels of these benzoxazinoids were significantly different among the wheat varieties/lines. However, none of these benzoxazinoids exhibited considerable correlation with aphid resistance. S. avenae feeding elevated the level of 2-O-β-D-glucopyranosyloxy-4,7-dimethoxy-(2H)-1,4-benzoxazin-3(4H)-one (HDMBOA-Glc) and reduced the level of 2-O-β-D-glucopyranosyloxy-4-hydroxy-7-(2H)-methoxy-1,4-benzoxazin-3(4H)-one (DIMBOA-Glc) in some of the wheat varieties/lines. Moreover, aphid-induced level of DIMBOA-Glc was positively related with callose deposition, which was closely associated with aphid resistance. Wheat leaves infiltrated with DIMBOA-Glc caused a noticeable increase of callose deposition and the effect was in a dose dependent manner. This study suggests that the constitutive level of benzoxazinoids has limited impact on S. avenae. Aphid feeding can affect the balance of benzoxazinoids metabolism and the dynamic level of benzoxazinoids can act as a signal of callose deposition for S. avenae resistance. This study will extend our understanding of aphid–wheat interaction and provides new insights in aphid-resistance wheat breeding. Full article
(This article belongs to the Special Issue Plant Protection Meets Metabolomics)
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