Special Issue "The Role of Natural and Synthetic Antioxidants in Alzheimer’s Disease"
Deadline for manuscript submissions: closed (5 October 2023) | Viewed by 1969
Interests: natural products; metabolomics; marine microbiology; endophytes
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Interests: natural products; pharmacognosy; medicinal plants; metabolism
Alzheimer’s disease (AD) represents a major socioeconomic burden worldwide. AD is a progressive neurodegenerative disorder that is clinically described by cognitive dysfunction as well as disorders in behavior and personality. The risk of acquiring Alzheimer’s disease increases dramatically with age. Thus, with an aging population, the number of people affected is set to increase even further, necessitating the development of therapeutic strategies capable of reversing or stopping the degenerative process. However, elevated oxidative stress has been revealed as a prominent and early aspect of vulnerable neurons in AD. Exposure to oxidative stress stimulates the accumulation of intracellular reactive oxygen species (ROS), which consecutively triggers cell damage in the form of protein, lipid, and DNA oxidation. Raised ROS levels are also coupled with the elevated accumulation of amyloid-β and the formation of senile plaques—a characteristic feature of the AD brain. Therefore, antioxidant substances are considered potential drug candidates as a treatment or preventive therapy of Alzheimer’s disease.
In the present Special Issue, we encourage submissions that detail the following topics: the isolation of natural products and extracts from natural sources, such as food waste or byproducts; the characterization of their metabolites; the design, synthesis, and structural elucidation of natural product molecules using various chromatographic and spectroscopic techniques; as well as the in vitro and in vivo documentation of their antioxidant, anti-Alzheimer’s properties.
Multidisciplinary manuscripts are encouraged, while those that only report the results of colorimetric antioxidant and phenolic determination assays (e.g., Folin–Ciocalteu, FRAP, and DPPH assays) without any characterization of plant extracts/essential oils with LC-DAD, LC-MS, GC-FID, or GC-MS will be not suitable for this Special Issue.
Prof. Dr. Usama Ramadan Abdelmohsen
Dr. Omnia Hesham Abdelhafez
Dr. Nourhan Hisham Shady
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- natural products
- food byproducts
- synthetic derivatives
- in silico approaches
- pharmacological network