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Metabolites
Special Issues
Response to Oxidative Stress as a Welfare Parameter
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Response to Oxidative Stress as a Welfare Parameter

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 5623

Special Issue Editors

Dr. Francesca Ciani

E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80138 Naples, Italy
Interests: oxidative stress; animal reproduction; nutraceuticals; phytotherapy; animal welfare
Special Issues, Collections and Topics in MDPI journals
Dr. Simona Tafuri

E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Production, University of Naples Federico II Via Mezzocannone, 80137 Naples, Italy
Interests: biochemistry and cell biology; oxidative stress and antioxidants; one health; animal welfare; metabolism and reproduction

Special Issue Information

Dear Colleagues,

Oxidative stress (OS) results from an imbalance between pro-oxidants (reactive oxygen species ROS) and antioxidants. In physiological concentrations, ROS are essential to maintain redox homeostasis in the cell, but at higher levels they can cause damage to biological molecules such as nucleic acids, lipids, and proteins, leading to loss of function and even cell death. Much evidence implicates a role of OS in the pathogenesis of several diseases, such as infertility, cancer, and degenerative disorders in animals and humans.

This Special Issue will clarify the fundamental role of ROS in cell signalling and metabolism and the molecular mechanisms of interactions between antioxidants and pro-oxidants as animal welfare parameters.

We encourage the submission of original articles, short communications, reviews, mini reviews, case reports, commentaries, and contributions regarding studies aimed at the detection and application of OS markers for the assessment of animal health and welfare.

Dr. Francesca Ciani
Dr. Simona Tafuri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidants
  • animal welfare
  • one health
  • reactive oxygen species
  • reproduction

Published Papers (3 papers)

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Research

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13 pages, 2690 KiB  
Article
Short-Term Estivation and Hibernation Induce Changes in the Blood and Circulating Hemocytes of the Apple Snail Pomacea canaliculata
by Cristian Rodriguez, Alejandra D. Campoy-Diaz and Maximiliano Giraud-Billoud
Metabolites 2023, 13(2), 289; https://doi.org/10.3390/metabo13020289 - 16 Feb 2023
Cited by 6 | Viewed by 1719
Abstract
States of natural dormancy include estivation and hibernation. Ampullariids are exemplary because they undergo estivation when deprived of water or hibernation when exposed to very low temperatures. Regardless of the condition, ampullariids show increased endogenous antioxidant defenses, anticipating the expected respiratory burst during [...] Read more.
States of natural dormancy include estivation and hibernation. Ampullariids are exemplary because they undergo estivation when deprived of water or hibernation when exposed to very low temperatures. Regardless of the condition, ampullariids show increased endogenous antioxidant defenses, anticipating the expected respiratory burst during reoxygenation after reactivation, known as “Preparation for Oxidative Stress (POS)”. In this work, we tested the POS hypothesis for changes in the blood and hemocytes of the bimodal breather Pomacea canaliculata (Ampullariidae) induced at experimental estivation and hibernation. We described respiratory (hemocyanin, proteins, lactate), antioxidant (GSH, uric acid, SOD, CAT, GST), and immunological (hemocyte levels, ROS production) parameters. We showed that, although the protein level remains unchanged in all experimental groups, hemocyanin increases in response to estivation. Furthermore, lactate remains unchanged in challenged snails, suggesting an aerobic metabolism during short-term challenges. Blood uric acid increases during estivation and arousal from estivation or hibernation, supporting the previously proposed antioxidant role. Regarding hemocytes, we showed that the total population increases with all challenges, and granulocytes increase during hibernation. We further showed that hibernation affects ROS production by hemocytes, possibly through mitochondrial inhibition. This study contributed to the knowledge of the adaptive strategies of ampullariids to tolerate adverse environmental conditions. Full article
(This article belongs to the Special Issue Response to Oxidative Stress as a Welfare Parameter)
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14 pages, 4079 KiB  
Article
Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress
by Qixin Wang, Yuwen Huang, Yu Li, Luyun Zhang, Huan Tang, Junzhe Zhang, Guangqing Cheng, Minghong Zhao, Tianming Lu, Qian Zhang, Piao Luo, Yinhua Zhu, Fei Xia, Ying Zhang, Dandan Liu, Chen Wang, Haiyan Li, Chong Qiu, Jigang Wang and Qiuyan Guo
Metabolites 2022, 12(11), 1128; https://doi.org/10.3390/metabo12111128 - 17 Nov 2022
Cited by 5 | Viewed by 1626
Abstract
Tripterygium glycoside tablet (TGT), as a common clinical drug, can easily cause liver damage due to the narrow therapeutic window. Glycyrrhizic acid (GA) has a hepatoprotective effect, but the characteristics and mechanism of GA’s impact on TGT-induced acute liver injury by regulating oxidative [...] Read more.
Tripterygium glycoside tablet (TGT), as a common clinical drug, can easily cause liver damage due to the narrow therapeutic window. Glycyrrhizic acid (GA) has a hepatoprotective effect, but the characteristics and mechanism of GA’s impact on TGT-induced acute liver injury by regulating oxidative stress remain unelucidated. In this study, TGT-induced acute liver injury models were established in vitro and in vivo. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), lactate dehydrogenase (LDH), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) were quantified. The anti-apoptotic effect of GA was tested using flow cytometry. Potential target proteins of GA were profiled via activity-based protein profiling (ABPP) using a cysteine-specific (IAA-yne) probe. The results demonstrate that GA markedly decreased the concentrations of ALT, AST, AKP, MDA, LDH, TNF-α, IL-1β and IL-6, whereas those of SOD, GSH and CAT increased. GA could inhibit TGT-induced apoptosis in BRL-3A cells. GA bound directly to the cysteine residue of PKM2. The CETSA and enzyme activity results validate the specific targets identified. GA could mitigate TGT-induced acute liver injury by mediating PKM2, reducing oxidative stress and inflammation and reducing hepatocyte apoptosis. Full article
(This article belongs to the Special Issue Response to Oxidative Stress as a Welfare Parameter)
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Other

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6 pages, 499 KiB  
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Therapeutic Stimulation of Glycolytic ATP Production for Treating ROS-Mediated Cellular Senescence
by Victor I. Seledtsov and Alexei A. von Delwig
Metabolites 2022, 12(12), 1160; https://doi.org/10.3390/metabo12121160 - 23 Nov 2022
Viewed by 1177
Abstract
Cellular senescence is conditioned through two interrelated processes, i.e., a reduction in adenosine triphosphate (ATP) and the enhancement of reactive oxygen species (ROS) production levels in mitochondria. ATP shortages primarily influence the energy-intensive synthesis of large biomolecules, such as deoxyribonucleic acid (DNA). In [...] Read more.
Cellular senescence is conditioned through two interrelated processes, i.e., a reduction in adenosine triphosphate (ATP) and the enhancement of reactive oxygen species (ROS) production levels in mitochondria. ATP shortages primarily influence the energy-intensive synthesis of large biomolecules, such as deoxyribonucleic acid (DNA). In addition, as compared to small biomolecules, large biomolecules are more prone to ROS-mediated damaging effects. Based on the available evidence, we suggest that the stimulation of anaerobic glycolytic ROS-independent ATP production could restrain cellular senescence. Consistent with this notion, non-drug related intermittent hypoxia (IH)-based therapy could be effectively applied in sports medicine, as well as for supporting the physical activity of elderly patients and prophylactics of various age-related disorders. Moreover, drug therapy aiming to achieve the partial blockade of respiratory chain and downstream compensatory glycolysis enhancement could prove to be useful for treating cardiovascular, neurological and hormonal diseases. We maintain that non-drug/drug-related therapeutic interventions applied in combination over the entire lifespan could significantly rejuvenate and prolong a high quality of life for individuals. Full article
(This article belongs to the Special Issue Response to Oxidative Stress as a Welfare Parameter)
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