Bioactive Lipids in Neuroinflammatory Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 10 January 2025 | Viewed by 708

Special Issue Editors

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Guest Editor
Campus Bio-Medico University of Rome, European Center for Brain Research Santa Lucia Foundation, Rome, Italy
Interests: inflammation; resolution of inflammation; bioactive lipids

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Guest Editor
1. Integrated Research Center, Campus Biomedico University of Roma, Rome, Italy
2. Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
Interests: alpha-synuclein; neurodegeneration; neuroanatomy; Parkinson’s disease; molecular biomarkers

Special Issue Information

Dear Colleagues,

Endogenous bioactive lipids such as arachidonic acid-derived autacoids (i.e., prostaglandins, leukotrienes, and thromboxanes), sphingolipids, specialized pro-resolving mediators (SPM), endocannabinoids, and fatty acyl esters of hydroxy fatty acids (FAHFA) are the effectors of a convoluted signaling network that controls initiation, coordination, and resolution of the inflammatory event; as a matter of fact, these molecules act on all cellular and molecular events of host defense, control phenotype, differentiation, and recruiting and trafficking of all immune cells, as well as their ability to influence tissue homeostasis through soluble mediators such as cytokines and chemokines. More importantly, the disruption of these lipid molecular networks, or their dysfunctional activity, is a primary event in the aberrant immune response that leads to neuroinflammatory damage of many—if not all—neurodegenerative diseases. This issue focuses on gathering the most recent molecular evidence on the involvement of endogenous bioactive lipids in neurodegenerative conditions, their role in kickstarting or preventing tissue damage, and their perspective either as possible therapeutic targets or diagnostic tools.

Dr. Alessandro Leuti
Dr. Giorgio Vivacqua
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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